Protein
Acarbose 7(IV)-phosphotransferase
Organism
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
Function
Catalyzes the phosphorylation of the alpha-glucosidase inhibitor acarbose. Phosphorylation of acarbose could be a resistance-like self-protection mechanism.
Similarity
Belongs to the carbohydrate kinase PfkB family.
Sequence
MSEHTDVLVLGGAGVDTIAYVPELPLPFQDSYVVAAIEPRAGQTGDNVALGLHTLGLRTMHVDVLGDDPEGDLVRAFHTRHGLPFAALPTAAGTKRAVNLVGPDGRRLSLWDGSREAEEDRYPAALIAAHTAHARHVHVCITPPGQHVFGQLNDLPVTVSTDLHNWDGAYEGFEVYAFNADLVFLSATALTDVAATMRRVIDRGRARLVVATDGAHGGSVLVRGETEVRRYAAVAPEAPVVDSNGAGDAFVSGFLFGHLAGEPLETCLRYGAIAGAYACTIPATRAGAIDRAALLRPAA