ABCA1

Phospholipid-transporting ATPase ABCA1

2261 amino acids

Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May involved indirectly in the efflux of intracellular cholesterol and its transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981).

Belongs to the ABC transporter superfamily. ABCA family.

254.302 kDa

MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

Abca1

Phospholipid-transporting ATPase ABCA1

2261 amino acids

Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May involved indirectly in the efflux of intracellular cholesterol and its transfer to apoliproteins to form nascent high density lipoproteins/HDLs.

Belongs to the ABC transporter superfamily. ABCA family.

253.912 kDa

MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDAQRLLLYSQRDTSIKDMHKVLRMLRQIKHPNSNLKLQDFLVDNETFSGFLQHNLSLPRSTVDSLLQANVGLQKVFLQGYQLHLASLCNGSKLEEIIQLGDAEVSALCGLPRKKLDAAERVLRYNMDILKPVVTKLNSTSHLPTQHLAEATTVLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNNTEEDVDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLVRTLLDSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

ABCA1

ABC transporter A family member 1

1882 amino acids

Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.

209.064 kDa

MGSSKRQFKAMLRKNWLLKTRHPFVTSAEILLPTIVMLLLIAVRTRVDTTIHPAHSNIDKDTVVEVGKGNSPSFPEVLKLLLAEGDFLAFAPDTDETNNMIDILSLKFPELRLVTKIFKDDIELETYITSAHYGVCSEVRNCSNPKIKGAVVFHEQGPHLFDYSIRLNHTWAFAGFPNVKSIMDTNGPYINDLEMGINTIPTMQYSFSGFLTLQQVVDSFIIFASQQNNDLPLSHSNLSSALRFELPWTLFSPSVIRMVPFPTREYTDDEFQSIVKSVMGLLYLLGFLFPISRLISYSVFEKEQKIREGLYMMGLKDEIFHLSWFITYALQFALCSGIITACTMGSLFKYSDKTLVFTYFFLFGLSAIMLSFMISTFFTRAKTAVAVGTLTFLGAFFPYYTVNDESVSMVLKVVASLLSPTAFALGSINFADYERAHVGLRWSNIWRASSGVSFFVCLLMMLLDSILYCALGLYLDKVLPRENGVRYPWNFIFSKYFGRKKNNLQNRIPGFETDMFPADIEVNQGEPFDPVFESISLEMRQQELDGRCIQVRNLHKVYASRRGNCCAVNSLQLTLYENQILSLLGHNGAGKSTTISMLVGLLPPTSGDALILGNSIITNMDEIRKELGVCPQHDILFPELTVREHLEMFAVLKGVEEGSLKSTVVDMAEEVGLSDKINTLVRALSGGMKRKLSLGIALIGNSKVIILDEPTSGMDPYSMRLTWQLIKKIKKGRIILLTTHSMDEAEELGDRIGIMANGSLKCCGSSIFLKHHYGVGYTLTLVKTSPTVSVAAHIVHRHIPSATCVSEVGNEISFKLPLASLPCFENMFREIESCMKNSVDRSKISEIEDSDYPGIQSYGISVTTLEEVFLRVAGCNLDIEDKQEDIFVSPDTKSSLVCIGSNQKSSMQPKLLASCNDGAGVIITSVAKAFRLIVAAVWTLIGFISIQCCGCSIISRSMFWRHCKALFIKRARSACRDRKTVAFQFIIPAVFLLFGLLFLQLKPHPDQKSITLTTAYFNPLLSGKGGGGPIPFDLSVPIAKEVAQYIEGGWIQPLRNTSYKFPNPKEALADAIDAAGPTLGPTLLSMSEFLMSSFDQSYQSRYGSILMDGQHPDGSLGYTVLHNGTCQHAGPIYINVMHAAILRLATGNKNMTIQTRNHPLPPTKTQRIQRHDLDAFSAAIIVNIAFSFIPASFAVPIVKEREVKAKHQQLISGVSVLSYWLSTYVWDFISFLFPSTFAIILFYAFGLEQFIGIGRFLPTVLMLLEYGLAIASSTYCLTFFFTEHSMAQNVILMVHFFSGLILMVISFVMGLIPATASANSYLKNFFRLSPGFCFSDGLASLALLRQGMKDKSSHGVFEWNVTGASICYLGLESIFYFLVTLGLELMPVQKVMSFSIGEWWQNLKAFKQGAGSSSTEPLLKDSTGAISTDMEDDIDVQEERDRVISGLSDNTMLYLQNLRKVYPGDKHHGPKVAVQSLTFSVQAGECFGFLGTNGAGKTTTLSMLSGEETPTSGTAFIFGKDIVASPKAIRQHIGYCPQFDALFEYLTVKEHLELYARIKGVVDHRIDNVVTEKLVEFDLLKHSHKPSFTLSGGNKRKLSVAIAMIGDPPIVILDEPSTGMDPVAKRFMWDVISRLSTRSGKTAVILTTHSMNEAQALCTRIGIMVGGRLRCIGSPQHLKTRYGNHLELEVKPNEVSNVELENFCQIIQQWLFNVPTQPRSLLGDLEVCIGVSDSITPDTASASEISLSPEMVQRIAKFLGNEQRVSTLVPPLPEEDVRFDDQLSEQLFRDGGIPLPIFAEWWLTKEKFSALDSFIQSSFPGATFKSCNGLSIKYQLPFGEGGLSLADAFGHLERNRNRLGIAEYSISQSTLETIFNHFAANS

abcA1

ABC transporter A family member 1

877 amino acids

Belongs to the ABC transporter superfamily. ABCA family.

97.375 kDa

MSTYSRYNDEDEIRNNKISFGDNIKREFLHLKLLLKKNLLVSIRSYFSTGIEILSPIAFIIILFLISHFGSGNENPIVTYNQELPICKSYGENRCFNIMFSPSNSPSAIAIMEMLGEINNNSIYSYPSDTGYLPDLNNTIGLKGGLIMMNSIEDSFEFVLAHPNVTIAAVDFLSIPLGFQINGAPPKNEPLLKMDGNSLEFNVVVNTTCPNILATCPDYSIAITTAIEKAVITYYSQKIRNEKIPPPTISYGSNAFPRYPPEQGAARVWGGLFYYCGSMISFIFLLYKVSFEKENKLKQGMVMMGLSVNQYWISWFITSFTIDILISLITIIVGLACQLPFFLGSNFFVLIITFSLFTISMSSVAFFLLTFIQSTKSAIGIGMGIFIVGSIFQLVFSGMGTMIFELIYQTNSNGALAARIILFFIPMFHFTKVLTDIGNVTTNYPLLTYKFSDLSTDLNIGGTVLKTVIPTTGQSICYLLALIGVYTVLAWYFEHIIPGNDGTSSPPWFFVLPSYWGLSLKKVRHIPTPYFDDEDVRAAITKAHDASNRAPLIICGLSKSYTKLFRPKKTVHAVKYLSLSVEKGTILGFLGSNGCGKSTTIGMLTGLLEPTAGDALVYGHSVISNIAAVRRITSVVPQHDILWAEMTAREHLQLFSELKGIPAQERESQIQKVLDQVRLSKISNNLISTYSGGMKRRLSVAIACIGDPKIIFMDEPTTGVDPSSKRHLIDLVKSIKNDKVIILTSHDMHEVEILADKIVIMNEGVMACNGNSLQLKSKYGEGYSVNIVAKSPESIPAVVEFVTLSIPGCKFMKQSALQLNFGFPVTIDHQIIANFFKQLEEITNDPNNQLMRDWSVSHSTLDDVFLKVSHLAKLKTQ