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Zfyve26

Gene
ZFYVE26
Protein
Zinc finger FYVE domain-containing protein 26
Organism
Ailuropoda melanoleuca
Length
2543 amino acids
Function
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
Similarity
Belongs to the ZFYVE26 family.
Mass
283.93 kDa
Sequence
MHHPFGKEETASQKQLFGFFCECLRRGEWELAQACVPQLHEAQGDIPKKVEDILQALVVCPDQLRCGQDIDPQRLAWVWFLVLEKWFSQEKKLLPSVFRRKLEFLLLSEDLRRDIPEDILKELYEALAQDTGGPVLDGNQKRESWTPRLSSEAVSVFWDLLRQAPQLAQALLELLRTKDDSAGLSGWSLQKALVDRVRRALGAVQGPTTGPAGIVDAIYGALRSLRCPAEPLGGELRLLCEELLEACRAEGSPLQEEQVLSCLLHKAGRSLVSLYGHIYAEKATEKPAKAVHLGKVSPDHLDPEQAMLALFCNPDPSQAWKSAYFYCLSNSKHFLEQILVTALALLKEEDFPSLGCLLDREFRPLSRLLVLLGWMHCQSLASAKRLLQTLHRAQDQGCDKLLRDACDGLWAHLEVLEWCVQQSSNPIPKRDLLCHLHGGDSHSVLYSLHHLTNLPALREEDVLKLLQKVPAKDPQQEQDSAEAPVPEHLSRCQNLTLYQSFCAMKYAIYALCVNSHQHSQCQECRDSPSEDPALAAEPANDSLSSPGASDLFSTYLARCQQYLCNVPDSLCLELLENIFSLLLITSADLHPEPHLPEDYAEDEDIEGKGLLGLRSPSESPQHIAQPERKSEQGCQEVPRSLACTVPNCLKTEPKESSPGLHGHSFLDLKHFTSGISGFLADEFAIGAFFRLLQEQLDKLSSHSPPEKPKLPEGQSCSGSRDGLQSRLHRFSKVLSEAQWRYKVVTSNQGSEEQPSRRYWPIATGHPSLRRGRRTRRSRPDGRDRSSNPSLESTSSELSTSTSEGSLNAVSGRNELDGRLQPQSQNSLIPMMFSPPESLLASCILRGNFAEAHQVVFMFNLKSSPSSGELMFMERYQEVIQELSRVEHKIENQNSDGGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLSTSGEPIPTLQEDFWISNTLVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNVSLESRGRRLDHILLSADGIRGFPVVLQQISKILNYPLTSAGQSKSESVEEKGAGPPRCSIAELLQMCWPSLTEDCVASHATLSQQLDQVLQVLREALQRPEPRSTPLSSLVEQAAQKAPEAEAHPVHIQTQLLQKNLGKQTPAGSRQTDYMGTFFSYCNTMAAVLLRSLSSEPDHMEVKVGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAREGLSLSVPKVIVNCCCEPLALCSSRQSQQTSSLLTHLDVLVQLHTSHCLEDLPLSTLSSPKPTGNSTLERKPHSSPRDSSLPAFTSSALAFLKSRSKLLATVACLGASQGPKLTKPSLSWKELRGRREVPLSAEQVAQECERLLEQFPMLKASLLAAWEPLRRSTEQGQSLAVSLCGRASLSTVLLGLHSPSALDVLTEAFEEALVARDWSRALQLTEVYGRDVDDLSNIKDAVLSCATACDKEGWRFLFPVKDASLRSRLTLQFVDRWPLEWCLEILAYCISDTAVQGGLKCELQRKLAELRVYQKILGLQATPVWCDWQSLRNCCIEDPSAVMNMILEAKEYGLCEEWGCLYPIPREHLISLHQKHLLHLLERGDHEKALQLLRKIPDPTMCLEVTEQSLDQHPSLAASHFLANYLTTHFYGELTAVRHHEIQALYMGSKVLLTLPEPHRASYSHLSSNPLLMLEQLLMNMKVDWATVAVQTLHQLLAGQEIGFTMDDIDSLLSIYAGKALDFPYSLREKRSDSLTHLQEVSQPSDLVTLSRSPSGEFSVAAAVAAPGVSTIHSPSPRERSFPESQPPPEFVPPATPPGRPQWVPDESASICMVCCRERFTMFNRRHHCRRCGRLVCSACSTKKMVVEGCRESPTRVCDQCYSYYNKDVPEENAGQPEAPDSSKSESPPYSAVVRVPKAAEVEWILDLNEEENELVRSEFYYEQSPSASLCIAILNLHRDSIACGHQLIEHCCRLSQGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGRSQDLALCDSYISKVDVLNILVAASYRHVPPLDQILQPAAVTRLRNQLLEAEYYQLGVEISTKTGLDPTGAWHAWGMACLKAGNLTAAREKFGRCLKPPFDLNQLSHGSRLVQDVVEYLESTVRPLLSLQDDDYFATLKELEATLRTQSLSLEVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYMRHSCMREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLETWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKTYTELGEKLSWLLKAKDHLKIYLQDTSRSTRRKKTTFFQKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAATYCRAARQLVEREKYSEIQQLLKCVSESGMAATSDGDTILLNCLEAFKRIPPQELEGLIQAIHSDDNKVQAYLTCCKLRSAYLIAVKQEHSRATVLVQQVQQAAKSSGDAVVQDICAQWLLTSHTRGSHGSGSRK

Gene
Zfyve26
Protein
Zinc finger FYVE domain-containing protein 26
Organism
Rattus norvegicus
Length
2542 amino acids
Function
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
Similarity
Belongs to the ZFYVE26 family.
Mass
284.215 kDa
Sequence
MSYPFGKEETTTEKQLFEFFCECLRRGDWELAQACVPQLQRGQGEIPQKVEDILQALVQCPILLRCGPDINPQRLAWLWLLVLEKWLPPEKKLLSTVFRRKLEFLFLSEDLQGGIPETILKELFETLAQGPAGCTSDRSQRWESGAPQLSPEAVSMLWNLLKQAPGPAQALLELLLEERHSASLCHSSLQKSLLDLIRKALQTLRDPASQPAGVTDAVCGALQALCCTAELPEGEWHVLCEELLETCRTEGSPLKEERLLGCLLHKAGRSLLSLYGHTYAEKVAERPPKASLSGKDHPDPERAMLALFSTPDPAHAWKMAFFYCLSNNKHFLEQILVTALTLLKEEDFPSLGYLLDREFRPLSHLLVLLGWTHCQSLESAKRLLQTLYRNQDQGHDELLRDACEGLWAHLEVLEWCVQQSSSLIPKRELLCHLHGGDSHSVLYSLHHLTNLPALREEEVLKLLQKVPTKDLQGEHDTHDASVPEHLSQCQSLTLYQGFCAMKYAVYALCVNSHQHSQCPDCRDSASSEELALVEPGRDSLPSPGASHLFPTYLARCRQYLQRIPDSLCLEILENIFSLLLITSADLHPEPHLPEDYAEDDDIEGKGPWGLWSPSESPQHIAATERRSERASMGPRDLAPTGPGCPKGEPKDNSPGPHTHSFLDLKHFTSSLSGFLADEFAIGAFLSLIQEQLNELSSHRTPEETELLEDQSCWAARDGLQGRLHRFSKVLSEAQWRYKVVTSNQSSEEQPSRRYRPTAKRHSSLRRGRRTRRTRADGRERGSNPSLEGTSSELSTSTSEGSLSAVSGQVEADNRFQPQPQSSIIPMMFSPPESLLASCILRGNFAEAHQVVLMFNLKSSPSAGELMFVERYQEVIQELARVEHKIENQNSDGGNNTVRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLSPSEDPIPTLQEDFWINAALTETNTPLRGVLEDLSPPAMAAFDLACCQCQLWKTCKQLLETAERRLSSSLEGRGRRLDQVVLNPDGMRGFPFVLQQISKILSYPLTVTGLTKSETLEERGGGAPRCSISELLQMCWPSLTEDCIASHTSLSQQLDQALQSLREALTLSEPKSTPLTCLVEQAAQKAPEAEAHPVHIQSQLLQKTLGKQTLAGPRQTDYVGAFFSYCSSLAKVLLRSLSSDPDNVEVKVGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAQEHLNLSVPQVIVSCCCEPLTLCLSRQSQQASSLTAHLGMLAQGHASHLLDGLPLSVLGSPRPSENPSAERKSDSSPKDSLPAFTASALAFLKSRSKILAMVACLRASRGTKVSRPSLSWKELRGRREAPLTAEKVAQECEHLLEQFPVFEAALLANWEPLQQASESRPSLAASLCGQARLSTVLLGLHSTLAQDVVTEAFEEALVARDWPRALQLIDVYGQDSDDLSSVRDSVLTCATVCDKEGWQYLFPVKDASLRSQLALRFVDKWPLESCLEILAYCVSDMAVPEELKSELQRKLTELRVYQKILGLQDPPVWCDWQTLRSCCAEDPSTVMDMMLGSQEYELCEEWGCLYPIPREHLVSLHHKHLLYLLERREYEKALQLLQRIPDPTMCLEVTERSLDQHPSLATSHFLANYLTSHFYGELTTDRHHEIQALYMGSKVLLTLPEQHRASYAHLSSSPLLMLEQLLMNMKVDWATTAVQTLQQLLAGQDIGFTLDEVDSLLSRYAGKALDLPYPLREKRSDSMIHLQEPVHQASDPETLSRSSSAEFSAAAAAPAPAAPGSALVCSPSPKERAFPQTQPPLEFVPPETPPARDQWVPDETESMCMVCCREHFTMFNRRHHCRRCGRLVCGSCSTKKMVVEGCRENPTRVCDQCYSYYNKDAPEESPCQSEVPDSAKNESPSYSAVVRIPKATEVEWILSLNEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSRGLTNPEVDAGLLIDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLHILVAAAYRHMPSLDQILQPASVTRLRNQLLEAEYYQLGVEVSTKTGLDSTGAWHAWGMACLKAGNLTAAREKFSRCLKPPLDLNQLSHGSRLVQDVVEYLESTVRPLVSLQDDDYFATLRELEATLRTQSLFLEAIPDGKIMNNTYYQECLFYLHNYSTNLAIISFYMRHNCLREALLHLLNKESPAEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGAYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQENSRSSGRKKTTFFRKKMAAADVSRHMNTLQLQMEVTRFLHRCESARTSQITTLPLPTLFGNNHMKMEVACQVMLGGKNVEDGFGIAFRVLQDFQLDAAVTYCRAARQLVEKEKYGEIRQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHSDDNKVRAYLTCCKLRSAYLIAVKQEHTQAAALVQQVQQAAKSSGDSVVQDICAQWLLTSHSRGAHGSGSRK

Gene
ZFYVE26
Protein
Zinc finger FYVE domain-containing protein 26
Organism
Homo sapiens
Length
2539 amino acids
Function
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.
Mass
284.576 kDa
Sequence
MNHPFGKEEAASQKQLFGFFCECLRRGEWELAQACVPQLQEGQGDIPKRVEDILQALVVCPNLLRCGQDINPQRVAWVWLLVLEKWLAREKKLLPVVFRRKLEFLLLSEDLQGDIPENILEELYETLTQGAVGHVPDGNPRRESWTPRLSSEAVSVLWDLLRQSPQPAQALLELLLEEDDGTGLCHWPLQNALVDLIRKALRALQGPDSVPPGVVDAIYGALRTLRCPAEPLGVELHLLCEELLEACRTEGSPLREERLLSCLLHKASRGLLSLYGHTYAEKVTEKPPRATASGKVSPDHLDPERAMLALFSNPNPAEAWKVAYFYCLSNNKHFLEQILVTALTLLKEEDFPNLGCLLDREFRPLSCLLVLLGWTHCQSLESAKRLLQTLHRTQGPGCDELLRDACDGLWAHLEVLEWCIQQSSNPIPKRDLLYHLHGGDSHSVLYTLHHLTNLPALREEDVLKLLQKVPAKDPQQEPDAVDAPVPEHLSQCQNLTLYQGFCAMKYAIYALCVNSHQHSQCQDCKDSLSEDLASATEPANDSLSSPGAANLFSTYLARCQQYLCSIPDSLCLELLENIFSLLLITSADLHPEPHLPEDYAEDDDIEGKSPSGLRSPSESPQHIAHPERKSERGSLGVPKTLAYTMPSHVKAEPKDSYPGPHRHSFLDLKHFTSGISGFLADEFAIGAFLRLLQEQLDEISSRSPPEKPKQESQSCSGSRDGLQSRLHRLSKVVSEAQWRHKVVTSNHRSEEQPSRRYQPATRHPSLRRGRRTRRSQADGRDRGSNPSLESTSSELSTSTSEGSLSAMSGRNELHSRLHPHPQSSLIPMMFSPPESLLASCILRGNFAEAHQVLFTFNLKSSPSSGELMFMERYQEVIQELAQVEHKIENQNSDAGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLNTSGDPIPMLQEDFWISTALVEPTAPLREVLEDLSPPAMAAFDLACSQCQLWKTCKQLLETAERRLNSSLERRGRRIDHVLLNADGIRGFPVVLQQISKSLNYLLMSASQTKSESVEEKGGGPPRCSITELLQMCWPSLSEDCVASHTTLSQQLDQVLQSLREALELPEPRTPPLSSLVEQAAQKAPEAEAHPVQIQTQLLQKNLGKQTPSGSRQMDYLGTFFSYCSTLAAVLLQSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLFERQVPPERLAALLAQENLSLSVPQVIVSCCCEPLALCSSRQSQQTSSLLTRLGTLAQLHASHCLDDLPLSTPSSPRTTENPTLERKPYSSPRDSSLPALTSSALAFLKSRSKLLATVACLGASPRLKVSKPSLSWKELRGRREVPLAAEQVARECERLLEQFPLFEAFLLAAWEPLRGSLQQGQSLAVNLCGWASLSTVLLGLHSPIALDVLSEAFEESLVARDWSRALQLTEVYGRDVDDLSSIKDAVLSCAVACDKEGWQYLFPVKDASLRSRLALQFVDRWPLESCLEILAYCISDTAVQEGLKCELQRKLAELQVYQKILGLQSPPVWCDWQTLRSCCVEDPSTVMNMILEAQEYELCEEWGCLYPIPREHLISLHQKHLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSHLSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSPSAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKSESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSLQDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLRSAYLIAVKQEHSRATALVQQVQQAAKSSGDAVVQDICAQWLLTSHPRGAHGPGSRK

Gene
Zfyve26
Protein
Zinc finger FYVE domain-containing protein 26
Organism
Mus musculus
Length
2529 amino acids
Function
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
Similarity
Belongs to the ZFYVE26 family.
Mass
282.961 kDa
Sequence
MSYPFGKEETATEEELFEFFCECLRRGDWELAQACVPQLHRGQGEIPQKVEDILQALVQCPILLRCGPDINPQRLAWLWLLVLEKWLAPEKKLLSTAIRRKLEFLFLSEDLQGDIPETILKELFETLAQGPAGSIPDRRTPQLSPEAVSVLWNLLKQAPRPAQALLELLLEDHHSASLCPSPLQKSLLDLIREALQTLRDPASQPPGVADAVCGALQALCCKAELPESEWRVLCEELLETCRTEDSPLQEERLLGCLLHKAGRNLLSLYGHTYAEKVAERPPKATLSGKDHPDPERAMLALFSTPDPAHAWKMAFFYCLSNNKHFLEQILVTALTLLKEEDFPSLGYLLDREFRPLSHLLVLLGWTHCQSLESAKRLLQTLYRTQDQGHDELLRDACEGLWAHLEVLEWCVQQSSNLIPKRELLCHLHGGDSHSVLYSLHHLTNLPALNEEEVLKLLQKEPTKDLQGEHETHDASVPEHLSQCQSLTLYQGFCAMKYAVYALCVNSHQHSQCQDCRDSASEDLALVEPGSDSLPSPGASHLFPTYLARCRQYLHSIPASLCLEILENIFSLLLITSADLHPEPHLPEDYAEDEDIEGKGPLGLRSPSESPQHIAATERRSERASMGPRNPAHTVPGCPKAEPKDSSPGPHKHSFLDLKHFTSGVNGFLADEFAMGAFLSLLQEQLTEISSHRTPEETKLPEDQSCSAARDGLQSRLHRFSKVLSEAQWRYKVVTSNQGSEEQPSRRYRPIATRHSSLRRGRRTRRTRADGRERGSNPSLEGTSSELSTSTSEGSLSAVSGQVESDSRFQTQPQSSIIPMMFSTPESLLASCILRGNFAEAHQVVLMFNLKSSPIAGELMFVERYQEVIQELARVEHKIENQNSDGGNNTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTEKLLSPSEDPIPTLQEDFWINATPMETTTPLREVLEDLSPPAMAAFDLACCQCQLWKTCKQLLETAERRLSSSLESRGRRLDQVVLNPDGMRGFPFVLQQISKILSYPLMQTGLAKSETLEERGGGAPRSSISELLQMCWPSLTEDCVASHTSLSQQLEQALQSLREALALPESKSTPLSCLVEQAAQKAPEAEAHPVHIQSQLLQKTLGRQTPAGHRQTDYVGAFFSYCSSLAAVLLRSLSSDPDHVEVRVGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAQEHLNLSVPQVIVSCCCEPLTLCLSRQSQQASSLLTHLGMLAREHASHLLDGLPLSTLGSPRPSENPSAERKSHSSPKDSLPAFTASALAFLKSRSKILAMVACLRTSRGTKVSKPGLSWKELRGRREAPLTAEKVAQECEHLLEQFPVFEAALLANWEPLQQASEPKQSLAASLCGQANLSTVLLGLHSSLALDILTEAFEGALVARDWPRALQLIDVYGQDLDDLSIVQDSVLTCAAVCDKEGWQYLFPVKDASLRSQLALRFVDKWPLESCLEILAYCVSDMAVQEELKSELQRKLMELRVYQKILGLQDPPVWCDWQTLRSCCAEDPSAVMDMMLDSQEYELCEEWGRLYPIPREHLVSLHHKHLLHLLERSEHDKALQLLQRIPDPTMCLEVTERSLDQHPSLATSHFLANYLTSHFYGELTTDRHREIQALYMGSKVLLTLPEQHRASYARLSSSPLLMLEQLLMNMKVDWATTAVQTLHQLLAGQDIGFTLDEVDSLLSRYAGKALDLPYPLREKRSDSMIHLQEPVHQASDSETLSRSSSAEFSAAAAPGSALVRSPSPKERAFPQTQPPVEFVPPETPPARDQWVPDETESVCMVCCREHFTMFNRRHHCRRCGRLVCGSCSTKKMVVEGFRENPTRVCDQCYSYYNKDTPEESPCQSEVPDSAKNESPPYSAVVRVPKATEVEWILSLSEEENELVRSEFYYEQAPSASLCIAILNLHRDSIACGHQLIEHCCRLSRGLTNPEVDAGLLIDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLHLLVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDSTGAWHAWGMACLKAGNLTVAREKFTRCLKPPLDLNQLSHGSRLVQDVVEYLESTVRPLVSLQDDDYFATLRELEATLRTQSLLLEAIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYMRHNCLREALLHLLNKESPPEVFIEGIFQPSYKSGKLHTLENLLESIDPTLESWGAHLIAACQHLQKNSYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYLQETSRSSGRKKATFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQVTTLPLPTLFGNNHMKMEVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAATYCRAARQLVEREKYGEIRQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHSDDNKVRAYLTCCKLRSAYLIAVKQEHSQAAALVQQVQQAAKSSGDSVVQDICAQWLLTSHSRGAHGSGSRK

Gene
ZFYVE26
Protein
Zinc finger FYVE domain-containing protein 26
Organism
Bos taurus
Length
2515 amino acids
Function
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).
Similarity
Belongs to the ZFYVE26 family.
Mass
280.355 kDa
Sequence
MHHPFGKEEAASQKQLLGFFCECLRRGEWELAKACVPQLHEAQGDIPKKVEDILWALVLCPNQLRCGQDISPQRLAWVWLLVLEKWLALEKKLLPTGFRRKLEFLLLSEDLPSDISEDILKELYAVLAQDRVDPVLDGNLRQESWPPRLSSEAVSMLWDLLREAPQVAQALLELLLGEVDGAGLRGWPLQKALVDLIRKALRTLQGPTAAPPGTVDAIYGALRTLRCPAEPLGAELRLLCEELLEACRSEGSPLREERLLGCLLHKAGRDLVSLYSHTYAEKATPSGKVPPDPLDPERAMLALFSNPDPAHAWKVAYFYCLSNSKHFLEQILVTALTLLKEEDFPSLGCLLSREFRPLSRLLVLLGWTHCQSLASAKSLLQTLHRTQDQGCDKLLRDACDGLWAHLEVLEWCVQHSSNPIPKRDLLCHLHGGDSHSVLYSLHHLTNLPALREEDVLKLLQKVPAKDPQQEHDSADTLVPAHLSQSQSLTLYRSFCAMKYAIYALCVSSHQHSQCRQCKDGPSDDLASVAEPMNDPPSSPGASDLFSTYLARCQQYLCSIPDSLCLELLENVFSLLLITSADLHPEPHLPEDYAEDAQPERKSEQGALGTARGLAYTVPSCPKPEPKDSSPEPHGHSFLDLKHFTSSVSGFLADEFAIGAFLRLLQEQLDELSSRGPPEKPKLLEDQSGSGSRDGLQSRLHQFSKVLSEAQWRYKVVTSIQGSEEQPSRRYRPITTRHPSLRRGRRTRKSRADDQDKGSRSSLENTSSELSTSTSEGSLSAASGKNELEGRLQPQPHSSLIPMMFSPPESLLASCILRGNFAEAHQVVFTFNLKSSHGSGELMFMERYQEVIQELAQVEHKIENQNSDGGSSTIRRTGSGRSTLQAIGSAAAAGMVFYSISDVTDKLLSTSGDPIPTLQEDFWISSCPMELTAPLKEVLEDLSPPAMAAFDLACSQCQLWKTGKQLLETAERRLNSSLESQGRRLDHVFVNADGIRGFPGVLQQISKILNYPLVSAGQIKSESGEDKGGGPPRCSIAELLQMCWPSLTEDCVASHTTLSQQLEQILQSLREALELPEPRSTPLSSLVEQVAQKAPEAEAHPVYIQAQLLQKNLGKQTAAGGKQTDYMGTFFRYCSTLAAVLLRSLSSEPDHVEVKVGNPFVLLQQSSSQLVSHLLLERQVPPDRLAALLAQEGLSLSVPQVIVNCCCEPLTLCSSRQSKQTSALLTRLGTLAQLHTSRCLDDLPLSTLSCLKSTENPTLERKPPSSPRDSSPPALTSSALAFLKSRSKLLATVACLGASRGSKVTKTSLSWKELRGRREVPLTAEQVARECERLLEQFPVLEASLLAAWEPLRGSSEQGQSLASSLCGQASLSTVLLGPHSPTALDVLTEAFEEALVARDWRRALQLTDVYGQDVDDLSSIQDAVLSCAAACDKEGWQFLFAVKDACLRSQLTLQFVDRWPLEWCLEILAYCLSDTAVQDGLECELRRKLAELQVYQKILGLQSTPVWCNWQALRNCCAEDPSTVMNLILEAKEYELCEEWGCLYPIPREHLINLHQKHLLHLLERGDHEKALQQQLLQRIPDPTMCLEVTEQSLDQHPSLATSHFLANYLTTHFYGELTADRHREIQALYMGSKVLLTLPEQHRASYAHLSSSPLLMLEQLLMNMKVDWAAVAVQTLRQLLAGQEIGFTTDEVDALLSRYAGKALDFPYPLREKRSDSVIHLQEIVSQVSDLETLSRSPSAEFSSATAPGVSTVHSPSVRERNFPPSQLPLEFVPPATPPARHQWVPDESESVCMVCRRERFTMFNRRHHCRRCGRLVCSSCSTKKMVVEGCRENPTRVCDQCYSYFNQDVPEENPGQAEAPDSSKSESPPYSAVVRVPKAAEVEWILDLNEEENELVRSEFYYEQAPSASLCIAILNLHEDSVSCGHQLIEHCCRLSQGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPAAVTRLRNQLLEAEYYQLGVEVSTKTGLDPTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLSHGSRLVQEVVEYLESTARPLLSVQDDDFLATLKELEATLRTQSLSLEVIPEGKILNNTYYQECLFYLHSYSTHLAIISFYVRHSCLREALLHLLHTESPPEVFIEGIFQPSYKSGKLHDLENLLESIDSSLESWGKYLIAACQHLQKKNYYHILYELQQFMKDHVRAAMTCIRFFTHKAKTYTELGEKLSWLLKAKDHLKIYLQETSRRSGRKKTTFFRKKMTASDVSRHMNTLQLQMEVTRFLHRCESAGTSQVTTSPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFRVLQDFQLDAAATYCKAARQLVEREKFGEIRQLLKCVSESGMAAQSDRDTVLLNCVEAFRRIPPQELEGLIQAIHSDDNKVQAYLKCCKLRSAYLIAVKQEHSRAAVLVEQVQQAAKSSGDAVVQDICSQWLLTSRSRGAHGSASRK