Function
Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:15814898, PubMed:26952984). Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG (PubMed:15814898, PubMed:18367448, PubMed:26952984). Involved in placental expression of many genes important for normal placental physiology (PubMed:26952984).
Sequence
MANNNLNRPLNTNVADSSNSSSTPGTAPPPSSSDPQVLGHQAPSSSASSLTEDCSSSFARDLNSYNNGQSGATGAVSWEAPHEPSEANAVSQIHPRNGEHSLQQKPKPQKVSGSSSLATSERYKTELCRPFEESGICKYGHKCQFAHGYRELRTLSRHPKYKTEPCRTFHSVGFCPYGTRCHFIHNQPEQQPVLSESTLEEPSSFNGSNVLHLGVNGEQQPGLQSDSPSGFLSVNSQALQAPLQLNQQALSSGGVMPSSHPAAANLRMMCCRTSSSTTAHDADKDPDKDADKDPSNNSANDALAFPQEPGDFSPVAFQNPNTATTTPTAFYNNQQQMGLAASAQFQMPLARPLPSATIFGQASVGPALTPGAAMAPGAALAPAAALTPAAALAPGAAMALGAAMATGAAMATGAALTPGAALALGAAMAAGAALAPGAAMAPGAAMATGAALAFGAAMATGTTLTPGAAMALGAAMATGAALAPGAAVAPRAALAPRAAFAPGAAALAPRAALPPGAALTPGAALAPGAALAPRAALPPGATLRPGAALIPRAALAPGAALAPGAALTPGAALAPGATLAPRAALAPGAALAPRITITSRAAITPGVAIAPGVATASTGILAPGAATATVGNTSSTTITAATAAEGAAPHFTFQLPDVESESESESLEFDVVTSTLDSLLVSDDEDEDDFLRRSSSSSSLNESEFDNTNSSRRLPIFSRFSDSEK