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ZWILCH

Gene
Zwilch
Protein
Protein zwilch
Organism
Drosophila melanogaster
Length
641 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:15886105, PubMed:17576797). Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores (PubMed:15886105, PubMed:17576797). Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex (PubMed:22685323). Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments (PubMed:22685323).
Similarity
Belongs to the ZWILCH family.
Mass
72.442 kDa
Sequence
MSASANLANVYAELMRRCGESYTITYGAPPTYLVSMVGAAEAGKKIVLVFKEDRNGAVARLRTTPTRAAPKKEGSADLDLTGSPLKDDCLVDAIADLSIDLQLDHSNPWKLEEEYQRGIPVDKARSIVCSEFLQLAEGLGSVWFLCDGSDLGQTQLLQYEFNPTHFSRGILSYQGVRPAYLVTSQALVRHHGKTPDETLIENSYQVNPHMRLRCSWTSSAALPLLVNLNDCDVALNHTFRVGDCGPLTQDFMNQLRILVYIREDIVSYHTDVKQGVSRDPTYRCGSGIDMDELRESINQTMTDVSGLIGRYSISNAEFDIEDVVQRAKVRQLTDLTDKLWELLKCCHSYKDLKIAFSMLFQCAARCNIVNTPTNKNRLAKIITELANRRLAMPCLSGAEPLELLLEIGLEKLYKDYEFIYTESKMCSTNLLKDDSSGASMDDGSPQNLPQLRKSLHNAVRGDPTPGAGMRKTLLHHHGAVNSRSTKYAGSDDDAGFKNSHFDEHESTERISKLFQIHCTLEHLLMMHIHLNLANVYNDVCSELLKKPPKLVESIDDQLSDVMDIRLSAHYVRDHLDGKDPYSRHITMRSHNKFRELKTTFYFNSENICPPNLAQCFQCDDKEMVKERTYHSWIYHKIRSLK

Gene
zwilch
Protein
Protein zwilch homolog
Organism
Xenopus laevis
Length
597 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity).
Similarity
Belongs to the ZWILCH family.
Mass
67.38 kDa
Sequence
MWAERHRAAVELQQFLSSVYEQVKKEESLGPFQFKDDIQVHVVCDGHCKPLESFCSGSEVLYILEKKPLTLEDNVLDETENNEGISFYTSLQEIPQPQAIPTMRARQFLTSYTLTHNPNMVQLNSGAPVKVLPPLWVRCDCSDAEGTCWLGAEPIKSSRNEITGMSFRTVTCAGPTADKSTFPSLDSLRQAHKERHYSSVMQTRGFAQYDLFGCNTVENSVIESQSSVTVDFVWNGVERILQLPPLASAATLNIKVESGDLRSPVYSVYKELDFLLVLAEGLKTGVTEWPETGETKSAVDLVQLLLNDLKNKVDGLTSSVSKKDNEKIKSDTAAVDCSIQSFITERGDLDFAEMLWCRMRKSVSSYQDVVNCFSLVIQSLKNGEVHPWIHRGSSSALSKLIQQSYHGKMQSVSLTGLTPMRMLLEIGLDKMKKDYISCFIGQDLATFNYLDYFISSSVDIQEQVQRVKKLHHMLEVVVVCNAFLSLGHENLFPLTQSCLKYYKENPWNEQHVFQLPIRPSVISTFYQNSHPQTWRVEIISGHGQKEVKTTWQLTSRRPVDHVSFAVPDVPIDMTISGENEEIVYYPTQVSCSQVNFC

Gene
zwilch
Protein
Protein zwilch homolog
Organism
Xenopus tropicalis
Length
597 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity).
Similarity
Belongs to the ZWILCH family.
Mass
67.494 kDa
Sequence
MWAERHRAAVELQQFLSSIYEQVKKGESLGPFQYKDDVQVHVVCDGHCKPLENFCSGSEVLYIMEKKPLTLEDNALDETENNEGISFYMSLQESPQPQAIPTMSARQFLTSYTLTHNPNMIQLNSGVPVKVLPPLWVRCDSSDAEGTCWLGAEPIKSNRNEITGMSFRTVTCAGPTADKSTFPSLDSLRQAHKERHYSSAMQTRGFAQYDLFGSNTVENSVIESQSSVTVDFVWNGVERILQLPPLTSAATLNIKVESGDLRSPVYSVYKELDFLLVLAEGLKTGVTEWPETSETKSAVDLVQHLLNDLKNKVDGLSTSVSKKDNEKIKSDTAAVDCSIQSFITERGDLDFAEMLWCKMRKSVSSYQDVVNCFSLVIQSLKHGEMHPWIHRGSSSTLSKLIQESYHGDMQSLSLTGLTPMRMLLEIGLDKMKKDYINCFIGQDLATFNYLDYFICTSVDLQEQVQRVKKLHHMLEVVVVCNAFLSLGHENLFPLTQSCLKYYKENPWNEQHVFQLPIRPSVISTFYQNSHPQTWRVEIISGHGQKEVKTTWQLTSRRPVDHVSFAVPDVPIDMTISGDNEELVYYPTQVSCSQVHFC

Gene
ZWILCH
Protein
Protein zwilch homolog
Organism
Homo sapiens
Length
591 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
Similarity
Belongs to the ZWILCH family.
Mass
67.214 kDa
Sequence
MWERLNCAAEDFYSRLLQKFNEEKKGIRKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHIEELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKINLPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKNYSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIALDISWSPVDEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLADGLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERIFFTNMVTCSQVHFK

Gene
ZWILCH
Protein
Protein zwilch homolog
Organism
Pongo abelii
Length
591 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity).
Similarity
Belongs to the ZWILCH family.
Mass
67.186 kDa
Sequence
MWERLNCAAEDFYSRLLQKFNEEKKGIRKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHIEELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKINLPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKNYSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIALDISWSPADEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLADGLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERIFFTNMVTCSQVHFK

Gene
ZWILCH
Protein
Protein zwilch homolog
Organism
Bos taurus
Length
589 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity).
Similarity
Belongs to the ZWILCH family.
Mass
66.385 kDa
Sequence
MWSGANRAAEEFYAGLLQEFDENKKGIRKDPFIYEADIQVQLISKGQPNPLKNILHENETIFIVEKVPLEKEEPSPIEELQSEDTAISDLSTGENVGLLALPIGRARQLIGFYTMAHNPNMTHLKINRPVTALPPLWVRCDGSDPEGISWLGAELISTSSNITGIVLYMVTCKVDKNYSVNLEDLKKSHKKRHHLSTLTASGFARYELFKSTALDDTVAASQTTITLDISWSPVDEILQTPPLSSTATLNIKVESGEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEFLNELSKLNEFGDSTKKDTEIVKHDAAAVDGSIECLLTVRGDLDFAEQLWCKMSSSVISYQDLVKCFSLVIQSLQRGAIQPWLHSGSNSLLSKLIHQSYYGTMDTVSLSGTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFISPSVDTQEQVHRVQKLHHILEIVVSCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQHIFQLPVRPTAVKDLYQNEKPQKWRVEINSGQKKVKTVWQLSDSPPIDHLNFHRPDFSELTLSGSLEERISFTNMVTCSQVHFK

Gene
Zwilch
Protein
Protein zwilch homolog
Organism
Mus musculus
Length
589 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity).
Similarity
Belongs to the ZWILCH family.
Mass
66.839 kDa
Sequence
MWSRMNRAAEEFYARLRQEFNEEKKGASKDPFIYEADVQVQLISKGQPSLLKTILNENDSVFLVEKVVLEKEETSQVEELQSEETAISDLSAGENIRPLALPVGRARQLIGLYTMAHNPNMTHLKIKQPVTALPPLWVRCDGSDPEGTCWLGAELITTNDIIAGVILYVLTCKADKNYSEDLENLKTSHKKRHHVSAVTARGFAQYELFKSDDLDDTVAPSQTTVTLDLSWSPVDEMLQTPPLSSTAALNIRVQSGESRGCLSHLHRELKFLLVLADGIRTGVTEWLEPLETKSALEFVQEFLNDLNKLDEFDDSTKKDKQKEAVNHDAAAVVRSMLLTVRGDLDFAEQLWCRMSSSVVSYQDLVKCFTLILQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGAMDSVPLSGTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFISPSVSTQEQVCRVQKLHHILEILVICMLFIKPQHELLFSLTQSCIKYYKQNPLDEQHIFQLPVRPAAVKNLYQSEKPQKWRVELSNSQKRVKTVWQLSDSSPVDHSSFHRPEFPELTLNGSLEERTAFVNMLTCSQVHFK

Gene
zwilch
Protein
Protein zwilch homolog
Organism
Danio rerio
Length
583 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity).
Similarity
Belongs to the ZWILCH family.
Mass
66.078 kDa
Sequence
MGSKIVSDANAFVKFLKLCQDESKDNCTYMDDVSVLLVKKEQLLHDIIGEKNQPIFICEKAQTKYEPEATETSADTSDVEDVLFKVEQDPGPQPLSIMKARQLLSWYTMAHNPNMSRLKAPENLHPLWVRCDKSDPCATAWLGVEITYSGNKTSGVKLYTVCCKGPTGDETAFTTLDELKQEHQNRHHTSAVSTKGYAQYNLFCSLTEESLMFESQSSVIASLTWNHVEKMLECPPLSSKATLNIKVAVGDIRSPLYQTYREMEFLLALAGGLRTGEIEWLEPVETQSAVDLTRALIEELENLAHGVPGHSAKASEKQKAKPDAAFSSMVIERGDLDFTEQLWEKMRKSVTSYQDITECMKIVVKAVKLGKIKPWIHKDSNSTLSKLILQSYQQQIDSVPLTGLAPANMLLELGLDKIRKDFINYLVGKELTTLNYLSYYLDTEVDLQEQVVRVRKLHHLLEILGTCSTFLSLPHERLFLFTQSCLQYYKTSNYDEDHIFQLQIKPALISYFYEKEQPFSWAVEVSSGQGSKEVKTSLYLSDKPLVDHIHLDLDVSLNESVNGDSEKMFYYRTMVSCSLINFI