Protein
Alpha-humulene synthase
Organism
Zingiber zerumbet
Function
Catalyzes the formation of alpha-humulene in the first step of zerumbone biosynthesis, a highly promising multi-anticancer agent. Also mediates formation of beta-caryophyllene at a much lower level.
Similarity
Belongs to the terpene synthase family.
Sequence
MERQSMALVGDKEEIIRKSFEYHPTVWGDYFIRNYSCLPLEKECMIKRVEELKDRVRNLFEETHDVLQIMILVDSIQLLGLDYHFEKEITAALRLIYEADVENYGLYEVSLRFRLLRQHGYNLSPDVFNKFKDDKGRFLPTLNGDAKGLLNLYNAAYLGTHEETILDEAISFTKCQLESLLGELEQPLAIEVSLFLETPLYRRTRRLLVRKYIPIYQEKVMRNDTILELAKLDFNLLQSLHQEEVKKITIWWNDLALTKSLKFARDRVVECYYWIVAVYFEPQYSRARVITSKAISLMSIMDDIYDNYSTLEESRLLTEAIERWEPQAVDCVPEYLKDFYLKLLKTYKDFEDELEPNEKYRIPYLQEEIKVLSRAYFQEAKWGVERYVPALEEHLLVSLITAGYFAVACASYVGLGEDATKETFEWVASSPKILKSCSIHCRLMDDITSHQREQERDHFASTVESYMKEHGTSAKVACEKLQVMVEQKWKDLNEECLRPTQVARPLIEIILNLSRAMEDIYKHKDTYTNSNTRMKDNVSLIFVESFLI