Protein
Zerumbone synthase
Organism
Zingiber zerumbet
Function
Catalyzes 8-hydroxy-alpha-humulene into zerumbone in presence of NAD. Also converts borneol to camphor in vitro. Zerumbone is a highly promising multi-anticancer agent.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence
MRLEGKVALVTGGASGIGESIARLFIEHGAKICIVDVQDELGQQVSQRLGGDPHACYFHCDVTVEDDVRRAVDFTAEKYGTIDIMVNNAGITGDKVIDIRDADFNEFKKVFDINVNGVFLGMKHAARIMIPKMKGSIVSLASVSSVIAGAGPHGYTGAKHAVVGLTKSVAAELGRHGIRVNCVSPYAVPTRLSMPYLPESEMQEDALRGFLTFVRSNANLKGVDLMPNDVAEAVLYLATEESKYVSGLNLVIDGGFSIANHTLQVFE