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ZNRF3

Gene
ZNRF3
Protein
E3 ubiquitin-protein ligase ZNRF3
Organism
Homo sapiens
Length
936 amino acids
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Similarity
Belongs to the ZNRF3 family.
Mass
100.574 kDa
Sequence
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA

Gene
Znrf3
Protein
E3 ubiquitin-protein ligase ZNRF3
Organism
Mus musculus
Length
913 amino acids
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959, PubMed:22895187). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Similarity
Belongs to the ZNRF3 family.
Mass
98.967 kDa
Sequence
MRPRSGGRPGAPGRRRRRLRRGPRGRRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPGAVCVETSNLTRGRQPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNLYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSSRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQTIPSVTPRGQSRAFPPSGASSLLFPTMVHVAPPTHVESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSNSSGQCRCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAGHSQSAGRGEPWLGPASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFEPQPFPPGSGIETSAGGSSLFLGPRLLEDCNPPSGEPQLGSSQGLYGLHSDHYPRTDGVKYEGLPCCFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPSCYAGPRDLSQRIPIIPEDVDCDLGLPQDCHGMHNHSPWGGALSLDVPRLHWSLGTTREEEQAPCYQAEVQPGCSPEEAGASRASLSSAPQDTQESHALAAEASGPGSGPGIGTGA

Gene
znrf3
Protein
E3 ubiquitin-protein ligase znrf3
Organism
Danio rerio
Length
868 amino acids
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Similarity
Belongs to the ZNRF3 family.
Mass
94.667 kDa
Sequence
MMILPRTGFGRGADSVVLVLLWVLGSVLAKDTAFVEVVLFESSPNGDYTTYTTGLQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPSCLTVLGKAKRAVQRGATAVIFDVSENPDAIDQLNQVSEDPLKRPVVYVKGADAVKLMNIVNKQKVARARIQHRPPRVRPTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQSSMNRMAIQALEKMETCKFKAKFKGQREASCGASDSVSSSSTSDCAICLEKYIDGEELRVIPCAHRFHKKCVDPWLLQHHTCPHCRHNIIDQKKGNPGAVCLDPGNPVHGRQQRVVLPVHYPGRVHRAGQVTAYPTRTSMDPHGNPITVLTVDQHPEQGLYPSQSSFIRGYPALHLDHTLNPHHCGLEHRGPAYPQTHTFKRPKFHGRNFSRAACFSQYETMYQHYYFQGLTFPQPEGQPSNGLHKGHNRPFQPGLLYPTVVHMAPASSSRLGDSGSTSGLSCYHGHRSVCSGYLADCPGSDSSSSSGQCHCSSSDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYVYRSKSPCRGSAGEAGAVFSAAPPADDTSAPVSGMIDCLQPPGGACYSSGDQLSNCSLEPNCSNHSSVETRELTSTTSAGPLEGNVAERSHNSVKPCGEQGVACNCCFEVPKLNLERKGKEGEDRGHCRWATEAQAVASSQNFYSVSTEQLPSPDHVSYDGLPCCFYTEMTVHRGGANHYAEDCSVNIQYAQTDSDGCMGQGCCELAQRIPIIPEDTDCELGLGPEPQTSLLSSRLTTEREERTSSEDTCDLFFTSGQCRGQVYQQPQDEEARALFSSKCNAVSETQGSSTSSFDGSGL

Gene
znrf3
Protein
E3 ubiquitin-protein ligase ZNRF3
Organism
Xenopus tropicalis
Length
853 amino acids
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (PubMed:29769720).
Similarity
Belongs to the ZNRF3 family.
Mass
92.605 kDa
Sequence
MKEPRIRGGLPLVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVPREGSCGGLDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGHGPVCVENSSNRGRQQQQQRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPLEPDLYPARTPTFLAGYRPVSLDHASSGHHCDLEHPPYPAPPAGHGFRRAKYSGRGFNNGTCYSQYETMYQHYYFQGLSYPHQQEVGGSQAPRVVENGHNHSFHSGNNMLYQPAPTLMHMAPPSSVGSCYLHSQHQHRSVCSGYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTFRSSLSSDFDPYVYRSRSPARTGGGDAPGCGGEGGTGSGRGRVECRSHQTFPNSPSRDRLSSCSMEMNYSSNSSLERRGAVISSGTVPDASVSISQGGGKDRRGPEKGCTCCFQRQAGDPSSDCTNLYLGPDPHQTSGPSSSGGLYSVTSSILHRTDPGTVLGHPSRPCCLYEENHGSCYNEDYAVSIQYALAEAAAAAAAAAVAGCEAGQPIPIIPEDPGYDGGLECVGHVSWEMEGEEEEEEVLYCQEGPCCALAEETRALCRSTGKEGAGSTTGQDCHPTDRD

Gene
znrf3
Protein
E3 ubiquitin-protein ligase ZNRF3
Organism
Xenopus laevis
Length
784 amino acids
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Similarity
Belongs to the ZNRF3 family.
Mass
85.475 kDa
Sequence
MVKDLLQNHMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDLKPCLTVLGKAKRAVQRGATAVIFDISDNPDAVEQLNQGLDDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVSREGSCGGLDTLSSSSISDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGHGPGCVENSLSHGRQQQQQRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPVEPDLYPARTPTFLAGYRPVSLDHASSGHHCDLEHPPYPAPPAGHAFRRAKYNGRGFNNGTCYSQYETMYQHYYFQGLSFPHQQEVGGSQASRVVENGHNHSFHSGNMLYQPAPTMMHMAPPSSVESCYLHSQHQHRSVCSGYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTFRSSLSSDFDPYVYRSCSPAKTGGGDAPASGGEGGTGRGRVECRSHQTFPNSPSRDRLSSCSMEMNYSSNSSLERRGAVLSSGTVPDASVSIAQSGGKDRRGPEKGCACCFQRQAGDPSSDCTTLYLGPEPHQTLGPSSSGGLYSVTSNILHRTDPGTVLGHPSRSCCLYEENHGSCYNEDYAVSIQYALAEAAAAAAAAAVAGCEAGQPIPIIPEDPGYEGGLEYVGHVSWEMEGDEEEVLYCQEGPCCMLEEETRALCRSTAKDRAGSTTGQDCHQTDTD