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ZHX2

Gene
ZHX2
Protein
Zinc fingers and homeoboxes protein 2
Organism
Pongo abelii
Length
837 amino acids
Function
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
Similarity
Belongs to the ZHX family.
Mass
92.154 kDa
Sequence
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDCWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIEATNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEIAPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTPVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSGSLAKEQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPVADDHGYDAVARKATKPMAESPKNGGDMVPQYYKDPKKLCEEDLEKLVPRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVAELAESDSDCVPAEAGQA
Protein
Zinc fingers and homeoboxes protein 2: ZHX2

Gene
ZHX2
Protein
Zinc fingers and homeoboxes protein 2
Organism
Homo sapiens
Length
837 amino acids
Function
Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Similarity
Belongs to the ZHX family.
Mass
92.307 kDa
Sequence
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA
Protein
Zinc fingers and homeoboxes protein 2: ZHX2

Gene
Zhx2
Protein
Zinc fingers and homeoboxes protein 2
Organism
Rattus norvegicus
Length
836 amino acids
Function
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.
Similarity
Belongs to the ZHX family.
Mass
92.107 kDa
Sequence
MASKRKSTTPCMVRTSQVVEQDVLEEADRAKDKGLGVPPSDVSKERWAAEPEPSSKESEVVEVRSVGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVSITASAPGSSDNDPGVSVGKTATVKTGKQKADAKKVPKKPDEAAPDNHMEGTARLVTDTAEILSRLGSVELLHDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTAVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAAQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDVVAPNGALSRLDQLSGAQLAGPLPSPSSAVVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHLSDDHGHDVASRRATKHVAESPKNGSEVAHQYAKDPKALGEEESEKLVPRVKLVGDPSKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSQRVAEGTVERADSDSDSTPAEAGQA
Protein
Zinc fingers and homeoboxes protein 2: Zhx2

Gene
Zhx2
Protein
Zinc fingers and homeoboxes protein 2
Organism
Mus musculus
Length
836 amino acids
Function
Acts as a transcriptional repressor (PubMed:19515908). Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (PubMed:30146259). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (PubMed:19515908).
Similarity
Belongs to the ZHX family.
Mass
92.259 kDa
Sequence
MASKRKSTTPCMVRTSQVLEQDMLEEADRAKDKGAGMPQSDVTKDSWAAEPEHSSKETEVVEVKSMGENLSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVPITASGPGSSDNDPGVSVGKTPMTKTGKLKADAKKVPKKPDEAAPENHMEGTARLVTDTAEILARLGSVELLQDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAPQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDAVAPNGALSRLDQLSGAQLAGSLPSPSSAIVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHMSDDRGRDAVSRKVAKQVAESPKNGSEAAHQYAKDPKALSEEDSEKLVPRMKVGGDPTKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSRRVAEGTVERADSDSDSTPAEAGQA
Protein
Zinc fingers and homeoboxes protein 2: Zhx2