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ZGPAT

Gene
ZGPAT
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Homo sapiens
Length
531 amino acids
Function
Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
Mass
57.359 kDa
Sequence
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAVEAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPCPFFLEGKCRFKENCRFSHGQVVSLDELRPFQDPDLSSLQAGSACLAKHQDGLWHAARITDVDNGYYTVKFDSLLLREAVVEGDGILPPLRTEATESDSDSDGTGDSSYARVVGSDAVDSAQSSALCPSLAVVGSDAVDSGTCSSAFAGWEVHTRGIGSRLLTKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCVETLQKQTRVGKAGTNKPPRCRGRGARPGGRPAPRNVFDFLNEKLQGQAPGALEAGAAPAGRRSKDMYHASKSAKRALSLRLFQTEEKIERTQRDIRSIQEALARNAGRHSVASAQLQEKLAGAQRQLGQLRAQEAGLQQEQRKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: ZGPAT

Gene
zgpat
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Salmo salar
Length
527 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity).
Mass
57.908 kDa
Sequence
MDEGTLEAAITAYSAQLQQVESALLAGLDPSQQADLLKLKEDLSQLIELTEASLVSVKKSRLLATLEEDDGLQSLATGTPANGGLDNEFAAFYSEVGEVSGSSSDMREREDEREEEDDGEVEGEVDALSGTKVRAPYRTSWGTLEYHNAMIVGTESCDRNEAQVRVLYVHPTQKSMKPCPFFLEDKCRFADNCRFSHGEVVYVSELREFLESDLTNLQEGSSCLARQDDGIWYSGKITDIDNDFYTVKFDSALLKNVMVEADGVIPPLREDDLPSCSDSEDDDNGEGEAAFPRVLTQEEDWAPSRSSSAFGGWEAHTRGIGSKLMLKMGYEYGKGLGKTSEGRVEPVLAVVLPKGKSLDQCAELTARKTQRKVAKGKDGQQVSRNKRTRKARAHNTGGCHNVFDFLNRKLGNGDANPEAGGTCGPPPSHTPSSQGAGVEAYKGGKSTKRNLNVKLFQAAERVAQTEREIQRLTESLSRRTGRDSSMVTHLEEKLSAARSLLVQQKAQELSAQRENRKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: zgpat

Gene
zgpat
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Xenopus laevis
Length
524 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity).
Mass
57.88 kDa
Sequence
MDEESLAAALQTYRAQLEQVDLTLRAVTDPTQLEDLTQLHTDLQQLIELTESSLLSIQKCNLLTSLEGNPSLPFHEDPISLPALEVPTSLSSQDKEYEAFRMAISEESQPLGSNDETSTCSKGSEEEEEEEEEEEDNTSGMKVKAPYYSTWGTLEYHNAMVVGSEQMEDGEAGVRVLYLYPTHKAMKPCPFFLDGKCLFNDNCRFSHGQVVSVTELQPFKEADLGSLAVDSPCLAQHNDGIWYPARITDIESGFYTVKFDSLLLKESVLEADSIIPPLRGSDSSSSSSSDEEEDGAAEDSVYAKVLGQEIAGTTCSSEFGGWEAHTRGIGSKLLVRMGYEFGKGLGRNAEGRVEPIQAVVLPKGKSLDQCMEIQQRKKAGGKHKHKTSKRRPKASGQGGGAKARDIFDFLNEKLEGKFTSACTAETQKTGEKKGKELYNASKDSKRALSVQVAITAEKIKQKQREICHLKESLARNAGRESVISNQLEVRLSGARKELAGLQQEERSLQREQKKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: zgpat

Gene
zgpat
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Xenopus tropicalis
Length
514 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity).
Mass
56.223 kDa
Sequence
MEEESLAAALHTYRAQLEQVELSLRAGTDPTQLEDLTQLRNDLQQLIELTESSLLSVRKCKLLSSLEGSASLPAPEEPAAISSQDEEYEAFRRAIGEEPQPPGAGDGASTGSKDSEEEEEEEDGSSGMKVKAPYYSTWGTLEYHNAMVVGSEQLEDGEAGVRVLYLYPTHKAMKPCPFFLDGKCRFDDSCRFSHGQVVALAELQPFAEADVASLAVGSPCLAQHSDGIWYPARITDIKSGFYTVKFDSLLLKESVLEADSIIPPLRGSDSSSSDDDDDDEEEDDAAEDSGYARVLGAGSAGSAHSSQFGGWEAHTRGIGSKLLARMGYEIGKGLGRNAEGRVEPIQAVLLPKGKSLDQCIEMQQRKKAGGKREHKAGKRRPRATGRGGGTKSARNVFDFLNEKLEGRPSGAQPGESRRAAERKGKELYNASKDSKRALSVQVAVTAQRIQQKQREIGHLQEALARNVGRDSVVSNQLELRLSGARRELVMLQQEEHSLQREQRKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: zgpat

Gene
ZGPAT
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Ovis aries
Length
513 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).
Mass
55.345 kDa
Sequence
MDEESLQTALRTYDAQLQQVELALGAGLDPSELADLRQLQGDLKELIELTEASLVSIRKSKLLAALDGERPVQEDAEPLAFQNAIVETAEVPVAPGAELETVPSRETGPGPTEPGQEEDDGEDEEGGAALSGRKVNAPYYSAWGTLEYHNAMVVGTEEADDGSPGVRVLYLYPTHKSLKPCPFFLEGKCRFQENCRFSHGQVVSVDELRPFQDPDLSSLQAGSACLAKRQDGLWYPARITDVDSGYYTVKFDSLLLKEAVVEGDSILPPLRTDPAGSSDSDGSDADDPSYARVVEPGAANPGTCSSAFAGWEVHTRGIGSRLLAKMGYEFGKGLGRRADGRVEPVHAVVLPRGKSLDQCAEILQKRTRAGQAGVSKPPKCRSRGSGPGGRPPPRSVFDFLNEKLKGGAPGAPEVGAAPPGRSGKEVYHASRSTKRALSLRLLQTEEKIEQTQRAIRGIQEALARNAGRHSVTTTQLQEKLAGAQRQLGQLRAQEAGLQREQRKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: ZGPAT

Gene
ZGPAT
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Bos taurus
Length
513 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).
Mass
55.285 kDa
Sequence
MDEESLQTALRTYDAQLQQVELALGAGLDPSELADLRQLQGDLKELIELTEASLVSVRKSKLLAALDGERPAQEDAEPLALQNAIAETAEVPVAPGAELETVPSRETGPGPTERGQEEDDGEDEEGGAALSGRKVNAPYYSAWGTLEYHNAMIVGTEEADDGSPGVRVLYLYPTHKSLKPCSFFLEGKCRFQENCRFSHGQVVSVDELRPFQDPDLSSLQAGSACLAKRQDGLWYPARITDVDSGYYTVKFDSLLLKETVVEGDSILPPLRTEPAGSSDSDGSDADDPSYARVVEPGAANPGTCSSAFAGWEVHTRGIGSRLLAKMGYEFGKGLGRHAEGRVEPVHAVVLPRGKSLDQCAEILQKRTRAGQAGVSKPPKCRSRGSGPGGRPPPRSVFDFLNEKLKGGAPGAPEVGAAPPGRSGKEVYHASRSTKRALSLRLLQTEEKIEQTQRAIRGIQEALARNAGRHSVTTAQLQEKLAGAQQQLGQLRAQEAGLQREQRKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: ZGPAT

Gene
Zgpat
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Mus musculus
Length
511 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).
Mass
56.411 kDa
Sequence
MDEDNLETALQTYRAQLQQVELALGAGLDASEQADLRQLQGDLKELIELTEASLLSVRKSKLLSTVDQESPAQEDAEYLAFQKAIAEEVEAPGAPCNDSETAPGSEVQPGSTSSALEEEEEDPDLEELSGAKVNAPYYSAWGTLEYHNAMVVGAEEAEDGSACVRVLYLYPTHKSLKPCPFFLEGKCRFKENCRFSHGQVVSVDELRPFQDPDLSLLQTGSACLAKHQDGLWHPARITDVDNGYYTVKFDSLLLKEAVVEGDSILPPLRTEATESSDSDTGDASDSSYARVVEPSTVDTGTCSSAFAGWEVHTRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCAEILQKKTKRGQAGSNRPPKCRRSGSRPEGRPPPRNVFDFLNEKLQSQVPGTPDAGVDTPERRNKDMYHASKSAKQALSLQLFQTEEKIERTQRDIRGIQEALTRNTGRHNMTTAHLQEKLEGAQRQLGQLRAQEADLQRKQRKADTHRKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: Zgpat

Gene
Zgpat
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Rattus norvegicus
Length
507 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).
Mass
56.172 kDa
Sequence
MDEDNLETALQTYRAQLQQVELALGAGLDASEQADLRQLQGDLKELIELTEASLLSVRKSKLLSTVDQEHQEDAEYLAFQKAIAEEAPVDPGNDSKTVPGSEVQPTPTSSALEEEEEDPDLEDLSGAKVNAPYYSAWGTLEYHNAMVVGAEEAEDGSACVRVLYLYPTHKSLKPCPFFLEGKCRFKENCRFSHGQLVSVDELRPFQDPDLSLLQTGSACLAKHQDGLWHPARITDVDNGYYTVKFDSLLLKEAVVEGDSILPPLRTEATDSSDSDTGDASDSSYARVVEANTVDTGTCSSAFAGWEVHTRGIGSKLLVKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCAEILQKKTKQGQTGASRPPRCRRRSSRPEGRPPPRNVFDFLNEKLQSQVPGTPDAGVDTPERRNKDMYHASKSAKQALSLQLFQTEEKIERTQRDIRGIQEALTRNTGRHGMATAHLQEKLEGAQRQLGQLRAQEADLQRKQRKADTHRKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: Zgpat

Gene
zgpat
Protein
Zinc finger CCCH-type with G patch domain-containing protein
Organism
Danio rerio
Length
504 amino acids
Function
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity).
Mass
55.727 kDa
Sequence
MDESSLEEAIGTYRAQLQQVELALSAGLGSAEQDDLLKLKEDLQQLIELTESSLVSVKKSQLLAALEEASTNQSDTSVPQETALDNEFAAFYAELSEDSNEVKPNPDTDEENEEEEQDISGTKVCAPYRTSWGTLEYHNAMVVCPEEPEGEEARVRVFYIHPTHKSMKPCGFYLEGKCRFMDNCRYSHGEVVCVSELRDFLEADISNMESGSACLAKHEDGIWYPARISEIEGGFYTVKFDSLLLKEAVLEADGIIPPLRQDDVSSSSSSDSEDDAECDGGYAKVFTSREEDLAQVNTAEFCGWEAHTRGIGSKLLMKMGYELGKGLGKTLSGRVEPVQAVVLPKGHSLDICAELTQRKTAAAIAKNNPTSHKRKAKKKKASTSTRHNVFDFLNSKLGDRAQSASHSSSSLVTGAEAYRGGKSTKRSLNVRLFEAAEKVTQVEREIQQLTKSLSKRNGRDAAVVSRLEEKLAASRKLLEQLKAQEQAIQREQKKADTHKKMTEF
Protein
Zinc finger CCCH-type with G patch domain-containing protein: zgpat