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ZDHHC20

Gene
Zdhhc20
Protein
Palmitoyltransferase ZDHHC20
Organism
Mus musculus
Length
380 amino acids
Function
Catalyzes palmitoylation of Cys residues on target proteins (PubMed:15603741). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains (By similarity).
Similarity
Belongs to the DHHC palmitoyltransferase family.
Mass
43.976 kDa
Sequence
MAPWTLWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVSTISRTGEKGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQDILRRAARDLPIYTTSASKAIRYCEKCQLIKPDRAHHCSACDRCVLKMDHHCPWVNNCVGFTNYKFFMLFLLYSLLYCLFVAATVLEYFIKFWTLCRRKSTENCPKNEPTVLNFPSAKFHVLFLFFVSAMFFVSVLSLFSYHCWLVGKNRTTIESFRAPMFSYGIDGNGFSLGCSKNWRQVFGDEKKYWLVPIFSSLGDGCSFPARLVGMDPEQASVANQSDYVRSIGSNQPFPIKPLSESKNRLLDSESQWLENGAEEGVTKSGTNNHVTVEIEN

Gene
ZDHHC20
Protein
Palmitoyltransferase ZDHHC20
Organism
Bos taurus
Length
365 amino acids
Function
Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains.
Similarity
Belongs to the DHHC palmitoyltransferase family.
Mass
41.907 kDa
Sequence
MAPCTLWRCCQRTVGWVPVLFITFVVVWSYYAYVVELCVFTLSGNGENGKAVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFCLSNSEKERYEKEFSQERQQEILRRAARDLPIYTTSASKTVRYCERCQLIKPDRAHHCSACDMCILKMDHHCPWVNNCVGFSNYKFFLLFLFYSLLYCLFVATTVLQYFIKFWTNELTDTRAKFHVLFLFFVSTMFFISVLSLLSYHCWLVGKNRTTIESFRAPMFSYGTDGNGFSLGCSKNWRQVFGDEKKYWLLPVFSSQGDGCSFPTRLVGTDPEQASVSNQSESARSIGSNQPFPIKPLSESKNRLLDSDPQWLESGSEEGVGGSGTNNHVTVAIEN

Gene
ZDHHC20
Protein
Palmitoyltransferase ZDHHC20
Organism
Homo sapiens
Length
365 amino acids
Function
Catalyzes palmitoylation of Cys residues on target proteins (PubMed:27153536, PubMed:29326245). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245).
Similarity
Belongs to the DHHC palmitoyltransferase family.
Mass
42.278 kDa
Sequence
MAPWTLWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGKNRTTIESFRAPTFSYGPDGNGFSLGCSKNWRQVFGDEKKYWLLPIFSSLGDGCSFPTRLVGMDPEQASVTNQNEYARSSGSNQPFPIKPLSESKNRLLDSESQWLENGAEEGIVKSGTNNHVTVAIEN