ZC3HC1

Nuclear-interacting partner of ALK

502 amino acids

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

55.262 kDa

MAAPCEGQAFAVGVEKNWGAVVRSPEGTPQKIRQLIDEGIAPEEGGVDAKDTSATSQSVNGSPQAEQPSLESTSKEAFFSRVETFSSLKWAGKPFELSPLVCAKYGWVTVECDMLKCSSCQAFLCASLQPAFDFDRYKQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRPEDLKTMCLTEDKISLLLHLLEDELDHRTDERKTTIKLGSDIQVHVTACILSVCGWACSSSLESMQLSLITCSQCMRKVGLWGFQQIESSMTDLDASFGLTSSPIPGLEGRPERLPLVPESPRRMMTRSQDATFSPGSEQAEKSPGPIVSRTRSWDSSSPVDRPEPEAASPTTRTRPVTRSMGTGDTPGLEVPSSPLRKAKRARLCSSSSSDTSSRSFFDPTSQHRDWCPWVNITLGKESRENGGTEPDASAPAEPGWKAVLTILLAHKQSSQPAETDSMSLSEKSRKVFRIFRQWESLCSC

ZC3HC1

Nuclear-interacting partner of ALK

502 amino acids

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity).

55.255 kDa

MAAPCEGQAFAVGVEKNWGAVVRSPEGTPQKIRQLIDEGIAPEEGGVDAQDTSATSQSVNGSPQAEQPSLESTSKEAFFSRVETFSSLKWAGKPPELSPLVCAKYGWVTVECDMLKCSSCQAFLCASLQPAFDFDRYKQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLEEPAILVSEFLDRFQSLCHLDLQLPSLRPEDLKTMCLTEDKISLLLHLLEDELDHRTDERKTTTKLGSDIQVHVTACILSVCGWACSSSLEPMQLSLITCSQCMRKVGLWGFQQIESSMTDLDASFGLTSSPIPGLEGRPERLPLVPESPRRMMTRSQDATFFPGSEQAEKSPGPIVSRTRSWDSSSPVDRPEPEAASPTTRTRPVTRSMGTGDPSGLEVPSSPLRKAKRARLCSSSSSDTSSRSFFDPTSQHRDWCPWVNVTLGKESRENGGTEPDASAPAEPGWKAVLTILLAHKQSSQPAETDSMSLSEKSRKVFRIFRQWESLCSC

Zc3hc1

Nuclear-interacting partner of ALK

501 amino acids

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal.

55.196 kDa

MAATSEGPLFAASIEKTWGSVVRSPEGTPQKVRELIDEGIVPEEGGTEPKDTAATFQSVDGSPQAEQSPLESTSKEAFFHRVETFSSLKWAGKPPELSPLICAKYGWVTVECDMLKCSSCQAFLCASLQPTFDFGRYKERCAELKKSLCSAHEKFCFWPDSPSPDRFGMLPLGEPAVLISEFLDRFQSLCHLDLQLPSLRPEDLKTMCLTEDAVSALLHLLEDELDFHADDRKTTSKLGSDVQVQATACVLSLCGWACSSLEPTQLSLITCYQCMRKVGLWGFQQIESSMTDLEASFGLTSSPIPGVEGRPEHFPLVPESPRRMMTRSQDATVSPGSEQSEKSPGPIVSRTRSWESSSPVDRPELEAASPTTRSRPVTRSMGTGDSAGVEVPSSPLRRTKRARLCSSSSSDTSPRSFFDPTSQHRDWCPWVNITLVKETKENGETEVDACTPAEPGWKAVLTILLAHKRSNQPAETDSMSLSEKSRKVFRIFRQWESSSSS

zc3hc1

NIPA-like protein

478 amino acids

Probable component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1).

53.19 kDa

MATSCEDVSPVKSPAVTPLKIRELINEGIVTGERSSIGRKETAVVPEENNGFEDPLSNSSYESTSKDAFFGRVESFSSLKWAGKPSELCPLICAKYGWSNIECDMLKCSSCNAYLCASLQPVLDFSKYKQRCVELQEALRKAHEKFCFWPDSPCPDYFWALMVTEPSSVLSDFVGRFDNLCHLEIQLPSIKHEDLKNMDITEETVSHLLRLIEDELKSKDGREDNSRLASDSLQVHISACILALCGWSTSYTSGSLCIINCPRCMRKVGLWAFQQLEAVELDNSLSAPNTPVSPAEGHERSPFGIMSPNRRVTRSRDAEQSPALAYGRTRSSDLLSPADSEAVRSRPVTRSMGQGESSGLSNELHSSPLRRSKRPRLCSSSSSDTSPRGCFDPLSQHRSWCPWVNVCQASETSTLGSEIQEEASRKEYGWKEVLNVLLAEENSRTLSDPDTSSVPEKSHKVFRIFRQWQMAASASENP

zc3hc1

NIPA-like protein

477 amino acids

Probable component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1).

53.291 kDa

MATTCEEVLVSPVKSTAVTPLKIRELINEGIVCGERSGIGRKEASETPEENTAFEDLPGNNSYESTSKDAFFSRVESFSSLKWAGKPPELCPLICAKYGWCNIECDMLKCSSCNAYLCASLQPILDFSKYKQRCVELQEALRKAHEKFCFWPDSPCPEHFWALLVTEPSSVLSDFVERFHNLCHLEMQLPSLKHEDVKSMDITEDTVSRLLRLIEDELKPKEGREANSHSLPSDSLQVHISACILALCGWNTSFSSGSLCIINCPRCMRKVGLWAFQQLETVELDNSLSAPGTPVSPAEGHERSPLGFMSPSRRVTRSRDAEQSPAFAYGRTRSSDLLSPADSEAVRNRPVTRSMGQGENTGLGNELHSSPHRRAKRPRLCSSSSSDTSPRSCFDPLSQHRSWCPWVNVCQASGTNTMGSEIQEEARRKEYGWKEVLKVLLAEENSRTISNPDTSSVPEKSHKVFRIFRQWQLAASS