ZBTB4

Zinc finger and BTB domain-containing protein 4

1013 amino acids

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

105.114 kDa

MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALLTSAPLPLPPATGGAAPNPATTTAASSSSSSSSSSSSSSSSASSSSSSSSSSPPPASPPASSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDAWVPPTPAPMATSQPEEDSFGPGPRPAGEWEGDRAEAQAPDLQCSLPRRPLPCPQCGKSFIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPGGPAGVDASALPPPVGFRGGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTLKLYRLLPMRAAKRPYKTYSQGAPEAPLSPTLNTPAPVAMPASPPPGPPPAPEPGPPPSVITFAHPAPSVIVHGGSSSGGGGSGTASTGGSQAASVITYTAPPRPPKKREYPPPPPEPAATPTSPATAVSPATAAGPAMATTTEEAKGRNPRAGRTLTYTAKPVGGIGGGGGPPTGAGRGPSQLQAPPPLCQITVRIGEEAIVKRRISETDLRPGELSGEEMEESEEDEEEEDEEEEEEDEEESKAGGEDQLWRPYYSYKPKRKAGAAGGASVGGSGLPRGRRPPRWRQKLERRSWEETPAAESPAGRARTERRHRCGDCAQTFTTLRKLRKHQEAHGGGSHSSRAGRRPSTRFTCPHCAKVCKTAAALSRHGQRHAAERPGGTPTPVIAYSKGSAGTRPGDVKEEAPQEMQVSSSSGEAGGGSTAAEEASETASLQDPIISGGEEPPVVASGGSYVYPPVQEFPLALIGGGREPGGGRGKSGSEGPVGAGEGDRMEGIGAAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGAGALPFLPGVFGYAVNPQAAPPAPPTPPPPTLPPPIPPKGEGERAGVERTQKGDVG

Zbtb4

Zinc finger and BTB domain-containing protein 4

984 amino acids

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

103.21 kDa

MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALLASAPLPLPPVTGGSAPSPATTTAASSSSSPPPPASPHSSSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDTWVPPAPSSMVTSEPNEDSLGPGLRTDGGWEGDKAEPLTPDSQPRRPFPCPRCGKSFIHPKRLQTHEAQCRRGSNTRGSAGLGPGGSGPGGPAGVDASALPQPVSFRDGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTLKLYRLLPMRAAKRPYKTYSQGAPEAPLSPSLHTPVPAVMPASPQPLLPSVPEPGPPHSVITFAHPAPSVIVHGSSSSGAAGGGPVGTGGSQAASVITYTTPPRPPKKREYPPPPPEPAATPTSPASTAVIPATAAGPATATEEAKGRNLRAGRTLTYTAKPVGGVSGSGGSPTGTGRGSSQLQAPPPLCQITVRIGEEAIVKRRISETDLRPGELSGEEVEESEEEEEEEEEEDQEDQEESKAGGEDQLWRPYYSYKPKRKAGATASGLSGLPRGRRPPRWRQKLERRGWEETPAVEGPGGRGRGERRHRCGDCAQAFATLRKLRKHQEAHSGGSHNSRTGRRSSTRFTCPHCAKVCKTAAALNRHGQRHAVERPGGTPTPVIAYSKGSIGTRPTDVKEEAPQEMQVSSSSGEAGGGSAAAAAAEASESASLQDPVISGGEEPPVAGGGGYVYPPVQEFPLALIGGSRDPGAGKGKPGNEGPVGASEGNRMEEMGTAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGGGALPFLPGVFGYAVNPQTAPPTPPTPPPPLPLPVPPKGVGEMTGVERTQKGDVG

Zbtb4

Zinc finger and BTB domain-containing protein 4

982 amino acids

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).

102.663 kDa

MPPPAEVTDPSHAPAVLHQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALLASAPLPLPPVTGGSAPSPATTTAASSSSSSPPPASPHSSSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDTWVPPAPTSMVTSDPTEDGLGAGPRTDGEWVGDKAEALTPDSQPRRPFPCPRCGKSFIHPKRLQTHEAQCRRGSNTRGSAGLGPGVSGSGGPAGVDASALPQPVGFRDGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWDTFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPRLNTLKLYRLLPMRAAKRPYKTYSQGAPEAPLSPSLHTPAPAAMPASPQPLPPPAPEPGPPPSVITFAHPAPSVIVHGSSSSGAAGGGPAGTGGSQAASVITYTTPPRPPKKREYPPPPPEPTATPTSPASTAVSPATAAGPATATEEAKGRNLRAGRTLTYTAKPVGGLSGSGGSPTGTGRGSSQLQAPPPLCQITVRIGEEAIVKRRISETDLRPGELSGEEVEESEEEEEEEEEEDQEEQEESKAGGEDQLWRPYYSYKPKRKAGATAGGASGVSGLPRGRRPPRWRQKLERRGWEETPSVEGPGGRGRGERRHRCGDCAQAFATVRKLRKHQEAHSGGSHTSRTGRRSSTRFTCPHCAKVCKTAAALNRHGQRHAVERPGGTPTPVIAYSKGSIGTRPTDVKEEAPQEMQVSSSSGEAGSGSAAAAEASESASLQDPVISGGEEPPVAGGGSYVYPPVQEFPLALIGGSREPSAGKGKPGNEGSLGASEGDRMEGMGTAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGGGALPFLPGVFGYAVNPQAAPPTPPPPLPLPVSPKGIGGMTGVERTQKGDVG