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Z600

Gene
Z600
Protein
Protein Z600
Organism
Drosophila melanogaster
Length
90 amino acids
Function
Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program (PubMed:10850494, PubMed:12919679, PubMed:17431409). Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition (PubMed:17431409). Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates (PubMed:17431409). At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell poliferation allowing cell fate specification and morphogenesis to take place (PubMed:12919679). Acts downstream or in parallel to the checkpoint regulator grp which is also required for the cell cycle pause at cycle 14 (PubMed:12919679). During gastrulation, delays mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place (PubMed:10850494, PubMed:12919679, PubMed:17431409).
Mass
10.53 kDa
Sequence
MSSTNETNQVLQRLNSLKIVETPKEQHEFGKRECYSLDSKKYSLVPATPSSSGHGKFQTELKKRRKNKLNRMYTYEADKNFIKARKSLNF