Protein
Zinc-type alcohol dehydrogenase-like protein YogA
Organism
Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
Function
Zinc-type alcohol dehydrogenase-like protein; part of the gene cluster that mediates the biosynthesis of phomenoic acid, a long chain aliphatic carboxylic acid that does not appear to be essential for pathogenicity but may play a role in allowing to outcompete other fungi in the environmental niche via its antifungal properties (PubMed:23396262). The polyketide synthase produces the long methylated aliphatic carboxylic acid chain of phomenoic acid (Probable). The cluster-specific cytochrome P450 monooxygenase may then hydroxylate the methyl group of carbon 31 (Probable). The putative dehydrogenase YogA, which has no obvious role in phomenoic acid biosynthesis, may further modify phomenoic acid to produce a compound not identified yet (Probable).
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Sequence
MPFTLTLKPKKAKGGQVYYPLQLNVVSKPAPGPNEVLIQLEAAALNHRDFFLRQNLYPGLSFKSPMLSDGCGTVVELGPGCTTASNQLLGKKVILTPFRGWDSDPEGPEDYSNFSTIGGVEPHFDLGMAQNYISVHESEVELLPEHLNHIEGAALPCCGITAWRALVTKSGNAKPGRNILVTGIGGGVAIQTLLFGVAMGCNMYVSSSSDEKLAKARELGAVGTVNYKTDSDSWDKTLGSLLPAERPYLDAVIDGAGGNIVTKALTVLKPGGVIVCYGMTVGPVMDWPMQAALKNVDLRGTMVGSRAEFREMVEFISTHKIKPVISRTVRGLDCVDAIDGLFEDIRTGKQFGKLVIEI