xrcc4

DNA repair protein xrcc4

454 amino acids

May be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (lig4). The lig4-xrcc4 complex is responsible for the NHEJ ligation step, and xrcc4 enhances the joining activity of lig4. Binding of the lig4-xrcc4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity).

Belongs to the XRCC4 family.

52.726 kDa

MNESSVSRFENITDDSGNTNGGFYYLKCNWQYNSFTIYLTDLTNVWSSNVTTKYIENILKPQGMSFDQYFQLLKKSLLKQDQTKREFDYKIDKYKRKNNNNINNNNEDIEFIIIIILSEFDNINVKSSIPLIKLSNHFTTFQHYFDWLFDKYQSLSLQNQTLTLQTQSLQSQFNQSLEQNKLFQLEKDRIESNLIEKFIIILNEKKKKIKEYKQPINNLLLEQKSISSSLSNCKCNNNNNNNNNKSIVNNNKNKSPSKQQVYTTPKKKKRNYQSNLINIDNDDDDDLGNNDNVNNINDENDNDNDNDNEEDYKPTFNNSTPPLLDLLSNDYDSYYNVPTNVRKKFKPTPTLTTTTTTTTTTTTASIIKTPTKKRNSISPQKSPHHHRNINIKKNNNNNNPSSPMKKYNANGTLIPNNNINSLIPITPMKSKSKLFNFNDDDNHDIGASELLNDL

XRCC4

DNA repair protein XRCC4

336 amino acids

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Belongs to the XRCC4 family.

38.287 kDa

MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI

Xrcc4

DNA repair protein XRCC4

326 amino acids

Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity).

Belongs to the XRCC4 family.

37.061 kDa

MERKVSRIYLASEPNVPYFLQVSWERAIGSGFVITLTDGHSAWTATVSELEISQEADDMAMEKGKYIDELRKALVPGSGAAGTYKFLFSKESQHFSLEKELKDVSFRLGSFNLDKVSNSAEVIRELICYCLDTITEKQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALEADLYQRFILVLNEKKTKIRSLHKLLNEVQQLEESTKPERENPCSDKTPEEHGLYDGSTDEESGAPVQAAETLHKDDSIFSSPDVTDIAPSRKRRHRMQKNLGTEPKMAPQELPLQEKERLASSLPQTLKEESTSAENMSLETLRNSSPEDLFD

XRCC4

DNA repair protein XRCC4

264 amino acids

May be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. May bind to DNA. The LIG4-XRCC4 complex is probably responsible for the NHEJ ligation step, and XRCC4 may enhance the joining activity of LIG4 (By similarity).

Belongs to the XRCC4 family.

29.854 kDa

MIGVDSKSSSTTFIETMVESEKTKHTCLRLEISGADPIFVKGTWHNSRFDISVTDGSSSWICNATEEEVAERAAQWDQPVSEYLKLAEQYLGFQQPNSVYSFSDALEGSKRLSWTFEKEGTKLEWRWKCKPSDDSKKITVGILDFLMEANIRLSEEVVNKTRSFEKMRSEAERCLAQGEKLCDEKTEFESATYAKFLSVLNAKKAKLRALRDKEDSVRVVEEEESTDKAESFESGRSDDEKSEEEASKKATSSKARGGKRAARS