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XPA

Gene
XPA
Protein
DNA repair protein complementing XP-A cells
Organism
Homo sapiens
Length
273 amino acids
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Similarity
Belongs to the XPA family.
Mass
31.368 kDa
Sequence
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETIVHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM

Gene
Xpa
Protein
DNA repair protein complementing XP-A cells homolog
Organism
Mus musculus
Length
272 amino acids
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity).
Similarity
Belongs to the XPA family.
Mass
31.398 kDa
Sequence
MATAEEKQTSPEPVAADEPAQLPAAVRASVERKRQRALMLRQARLAARPYPAAAATGGVASVKAAPKMIDTKGGFILEEEEEKHEIGNIVHEPGPVMEFDYTICEECGKEFMDSYLMNHFDLPTCDSCRDADDKHKLITKTEAKQEYLLKDCDLEKREPALRFLVKKNPRHSQWGDMKLYLKLQVVKRALEVWGSQEALEDAKEVRQENREKMKQKKFDKKVKELRRAIRSSVWKRETTTHQHKYGPEENLEDDMYRKTCTLCGHELTYEKM

Gene
XPA
Protein
DNA repair protein complementing XP-A cells homolog
Organism
Gallus gallus
Length
267 amino acids
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
Similarity
Belongs to the XPA family.
Mass
30.978 kDa
Sequence
MGRAAPGPDEGAEGERPSISATALARMERNRRRALALRQARLAARPYPQAAAGAGPPQGRDTGGGFFLEEEEEEEEQRRAAERIVHPPAPVLQFDYLICGDCGKEFMDSYLMQHFDWATCDNCRDAEDKHKLITRTEAKEEYLLKDCDLDKREPVLRFIVKKNPHNPRWGDMKLYLKLQVIKRALEVWGNEESLQEAKEQRRDSREKMKQKRFDKKVKELRRAVRSSLWKKTASIHEHEYGPEENVDEETYKKTCTVCGHELTYEKM

Gene
xpa
Protein
DNA repair protein complementing XP-A cells homolog
Organism
Xenopus laevis
Length
267 amino acids
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
Similarity
Belongs to the XPA family.
Mass
31.18 kDa
Sequence
MEPEPEPEQEANKEEEKILSAAVRAKIERNRQRALMLRQARLACRPYPTGEGISTVKAPPKVIDSGGGFFIEEEEAEEQHVENVVRQPGPVLECDYLICEECGKDFMDSYLSNHFDLAVCDSCRDAEEKHKLITRTEAKQEYLLKDCDIDKREPVLKFILKKNPHNTHWGDMKLYLKAQVIKRSLEVWGSEEALEEAKEVRKDNRDKMKQKKFDKKVKELRRTVRSSLWKKEASGHQHEYGPEEHVEEDSYKKTCITCGYEMNYEKM

Gene
XPA
Protein
DNA repair protein complementing XP-A cells homolog
Organism
Cricetulus griseus
Length
97 amino acids
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity).
Similarity
Belongs to the XPA family.
Mass
11.519 kDa
Fragment
single
Sequence
SYLMNHFDLPTCDSCRDADDKHKLITKTEAKQEYLLKDCDLEKREPALRFIVKKNPRHSQWGDMKLYLKLQVVKRALEVWGSQDALEDAKEVRQENR