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War-044

Gene
War-044
Protein
Inhibitor of apoptosis protein
Organism
African swine fever virus (isolate Warthog/Namibia/Wart80/1980)
Length
224 amino acids
Function
Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation. Induces also the activation of host NF-kappaB.
Similarity
Belongs to the asfivirus IAP family.
Mass
26.558 kDa
Sequence
MFPKINTIDPYISLRLFEVKPKYVGYSSVDARNQSFAIHDIKNYEKFSNAGLFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKKLEDMGFSKPFMQFILANAFIPPYRKYIHKIILNDRYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL