WWC1

Protein KIBRA

1113 amino acids

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

Belongs to the WWC family. KIBRA subfamily.

125.301 kDa

MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV

wwc1

Protein KIBRA

1108 amino acids

May play a role in the regulation of the Hippo signaling pathway.

Belongs to the WWC family. KIBRA subfamily.

125.267 kDa

MIRKELPLPEGWEEARDVDGKVYYIDHTSKTTSWIDPRDRFTKPLTFADCIGDELPLGWEESYDTQVGVYYIDHNSQTTQIEDPRVQWRREQERMLKDYLVLAQEALLAQKEIYQVKQQRLELAQKEYRTLNDVWKHKVGSQTSLVSGSSSSSKYDPDILKAEIATTKSRVNKLKREMVFLRQELQYKENGYQTLKEIDLKMSKNHCAYKLDEAQAILNEMKTIKKAITSGEREKQDLIQSLAELKNGFLVDKGSQSDLWASNTSLASSANSLSRQYLNVSSQTDISGNLSVVSNNHLAEKVRLQLRYEEAKRRIANIKIQLAKIDSDAWPGVLDSERDRLILISEKEELLKEMRFISPRKWSQSEVERLESEKKQLEEDLQAARDTQSKALTERLKMSSKRNQLVKELEETTRLIASLQAQLKCLSTSMQSLSSGSSPGSLASSRGSLVTSSQDSSTSASVSDLYYEQLDHLDSEYQNKVDFLIQEGAMGYRPSGCITTIHENEVVRSQKTDPANRVKALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLVTDPLLTVDAFLSQIDFEDIDLPLSFTELNVNAGGDSYQHETDEEPSGQGLSCLGVSSLSVAGVSAAVSDESVTGDSGVYEATNQRTLMENAVFDGEDSEMMDTAKIKIGMKYDEKNKHFAVFVIQLDNLAALLLHQNEKLYIRVAVLPCSESTSCLFRTRTLEQSDTLLYNEMFLVSTSHSALRQKTLRVDVCTRQSNHHEECLGGSQISLADVCHSEEQEAHWYNLLSYRYLKRQSKTSKQKISCCEESGIENPDSVSALLKQTAAELEAVRKQIGESTDPPEYIWPEKKDNVPDEDGISENEGEEEFDGDVQCETEESDMQAATDSASVKVDKETNTEGLAMSLSSVRPKDKRAATPMQAPFIRGNTIIRSKTFSPGPQSQYICRLNRSDSESSTLSKKPPFVRNAMERRSVRVKRPSVKSTGSERLIRTSLDLELDLQASRTWHHQLTQEISVLRELKEQLEQAKRLGENELPQRVKDDETFKVMLRQVEKQVQKIEQKYEMQADKMMRAAAKDVHRLRGQSSKEPLEVQSFREKMAFFTRPRMNLPTLTADDV

Wwc1

Protein KIBRA

1104 amino acids

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade.

Belongs to the WWC family. KIBRA subfamily.

124.11 kDa

MPRPELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQGGYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPMPKQFLDVSSQTDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFEQLDSELQSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFLAPLEFEDTELSTTLCELNLGGSGTQERYRLEEPGPEGKPLGQAASVAPGCGLKVACVSAAVSDESVAGDSGVYEASAQRPGTSEAAAFDSDESEAVGATRVQIALKYDEKNKQFAILIIQLSHLSALSLQQDQKVNIRVAILPCSESSTCLFRTRPLDSANTLVFNEAFWVSISYPALHQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQCREPQPTEAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASENEAVAEEEEEGEEDVFTEKVSPEAEECPALKVDRETNTDSVAPSPTVVRPKDRRVGAPSTGPFLRGNTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLRTERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEHLEQAKNHGEKELPQWLREDERFRLLLRMLEKKVDRGEHKSELQADKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV