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WOR2

Gene
WOR2
Protein
White-opaque regulator 2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
446 amino acids
Function
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
Mass
49.106 kDa
Sequence
MTQLPSVSELINRTGSIGSSSNITRVPPMTTTSATNTTTAATATTVTSTTPRSENSYSPNSPYSLPTRPSNTSLTNYSAGSGITVASSSFQFSQPSPGRSKHNSTSSQSSSGDSFQQHQSNPSGVSMSSNTSPRTSIVQSMSSVPTPPSTGPAPQQFVYQESQLPVQPPPQQQQLQQPPPPPPQQQQHIYPQQQPNFPYHNNFVSPPTYTTAYPQYYYQPVMTPPHHQPHQQAPIHLANNVSILQSQAVMQNAYPTTHYLQHVGPHHIYANVNSQVYYQDMAREEANKALINKRRIIKRRTRTGCLTCRKRRIKCDERKPTCFNCERSKKSCLGYQDLSKLPPRKRNRDTSLDLPDGNQQQQQQQQNQQSIVGGAGNVSDEPHNETHQITSISGSSTNSRNLDMMIPQSFRNNISSQPINFYGPVATTASGASAVINRVSVADLLK