WIT2

Gene

WIT2

Protein

WPP domain-interacting tail-anchored protein 2

Organism

Arabidopsis thaliana

Length

627 amino acids

Function

Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips (PubMed:18591351). Plays a role in nuclear shape determination (PubMed:25759303). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).

Mass

71.852 kDa

Sequence

MEEIIREDYFEALSSRNEEEQEMLRMLTKLEIDSAYTSEKLMNLHVLLMHLLAWDNDLEGMGTLDSSPASFEKALTFDLLCGILESEVKEVDEVLDVLEAQIVDTSYKISSCKHGNYIVIEGKLGESAESLKQSRGQVSEITLQLAQLRRTLHYIRNGTSENEESVELRQKYALKPSDLRHKNALRMLEKSLSRELELEKKLMEFQQNEEQLKLKLHYTEEVSSRMEEASEFIWGRFLEADNSSEVLTGISKELVGRLQILQFSLNGSAQRESELKSKLEDCTVQLEAKDLLVQKLEGTISENSEIVSEVLTLREYVKSAEQKLKNTDLELKSVNASKQEILVHLAEMENANESVKENLFEAESRAESGEAKIKELDAANLELTEELNFLKDADDKKTKKVNSLEKQVRELEVQVQNSKVSSEANQEQQNMLYSAIWDMETLIEDLKSKASKAESRTETVEEQCIVLSTTNSELNKDVSFLRQKAKSLEAMLDLANNEKERYAQEITTRNKVLMDMMLQLSSERERIQEQLYSLAKENKILRVNQCSNTYQRNGSYAGDKELSFHADGHEIEALAESLQEDERTREEPEKQSVSEKSSEIRRAIKLKHILVVALVFVLFCSFFGVTY

Protein

WPP domain-interacting tail-anchored protein 2: WIT2