wdr91

WD repeat-containing protein 91 homolog

766 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.

Belongs to the WD repeat WDR91 family.

86.258 kDa

MNSSNLNYLDELVKEYLIFRGFTQTNHYFSLEKKGDKLKGFQVDRILEQINIYISSYDINHLVELWNFLDITFFSKIDYNKSNAYNNNNNNNNNYNSNHNSNGSYTSYRNNNNDLQSTIKKLSSSLRKYYVIYAINNNKIDKVKEFFDQYSLELLKDPDWQSWFALPYIRNPQSDPLFEIYFSKTWSEAFSLSLRNFLSTIFKNIPLPKILQFNLERQNRKRLETQVENLLSINEELRSQVDKLEYQNKRDQNNSGSNNNSNNNSNSGFTIGNVSQRKESNVNNFNSGNDLNSSNEREVNSFSRVSKRFEPRSTSSTNIAAMDDDDNKPMIGIGRSRKSISTNSVNSNNNINNNNTSNTNTNTNTNTNTNTNSNSNTNTNTNSNSNTNTSNNNSNSNNNNNGTNTNVTNNNGFQHLNLSGFEMTEIDENGFKKKSSNGLNGSDGIENGELVYNIESQEVCTSHSSAITRCKFLSNGSKIASSSIDGTVRLWNVGFSSRQTTIYCLSEVASLEWENRSKLLLCGTIDSKIKIWNSLTDKAIGDINTSIEFPRVEDIACNPNGNSFATSSINNGRTDGVVYTWNLRTLKTEEKLSSSGAVINSMSFNSTGTLLSTGCVDGTIRIFDIKSGSPIAGWQAHSNEILSVQFSSDENRLYSLGKDGKLYQWNIHSMGKPVKEYDYPGFLVDPHRTTKISFNHNQSSFLVGTNNKFALLYNIDQSSPILQISGHTGPVVTCDWNSSSQSDVIITGSLDKTIRLTKLSKSFNNL

WDR91

WD repeat-containing protein 91

751 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.

Belongs to the WD repeat WDR91 family.

83.419 kDa

MAAATERTDELVREYLLFRGFTAALKQLDAEIKADREKGFRVDKIVEQLQQFVQSYDLAALRDYWGYLDRRLFSRLEDMYRPTVNKLKTSLYRYYLVHTVQTGRNDKAQEFFLKQASELQNQAEWKDWFVLPFLPAPDSNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNLEAECHRSSLIQEENESLRHKLFALQAESSRMKKEELEVEEAVVHHKLPAYVANMDRLGDSELDMTCSQRSTAHSLQSRGGFLSSLLSQSKKGPARPAQPSGASPTQTGSVLLGKKEPANHQSAKGKEGTASSKDGKSHFSGLVAGESSSLQQRQKRLQEHGKERRELLSKGTSQVQSAEKKADISTSEPEPCSEPQADQAETSTKMPASSTESVGVRQEQPFIVLSQEEYGEHHSSIMYCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEISIDEDMPRILSLACSPSGASFVCSAAAQSPISHMDFSVVTSGGKSMNQVPGKLLLWDTKTMKQQLQFSLEPEPIAINCTAFNHNGNLLVTGAADGIVRLFDMQQHECAMSWKAHDGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKISEYALPSEATGPFVLSGYSGYKQVQFPRGRLFAFDSEGNYMLTCSSTGGVIFKLNGEDKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAQKS

wdr91

WD repeat-containing protein 91

751 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.

Belongs to the WD repeat WDR91 family.

83.76 kDa

MTSAVELTDDLVKEYLTFRGFTNTLKYFEVDIKADKDKGFRVDRIVEQLLQFVQSYDLNGLVEYWAYLERRLFSRLEDVYRPTIHKLKTSLFRYYLVYTIQSSRTDKAHEFFQKQATELQNQAEWKEWFALPFLPTPDSNRTFSTYFSRQWADTFTVSLHNFLSVLFQCMPVPKILTFQSDYQKIACLQEENEIMRQKLFALQAETYRLRKDGPSEPLVLHKLPHYVSNMDRLGDSELGSNIMSSHSNTNMNTPSQRTSGFLSSLLAQNKKPPPPKSTLPSVSSPTQSGGSVPLKKEVAVSQAQKAKELVGGTKEVRSSPNILGVPGTESSMVQQRHKRQQERKELLSKTASQVSTEKKAENSDADPDLRSDTQNDTVDAVTRGSGASGARKEEKPAQPFIVLSQDEYAEHHSSIMHCRVDCSGRRVASLDVDGVIKIWSLDGIMQTKASAISKSALLSLEWATKRDRLLLLGSEVGTVRLYDTEAKKNLCEIGIVEDMPRILSLACSPSGASFVCSAAAATSPSQTDPTYYSYGESGNNQVPGKLLLWDTKTMKQQLQFSLEPVPIAVNCTAFNHNGNLLVTGAADGFIRLFDMQQHQCALSWKAHMGEVYSVDFSYDENAVYSIGEDGKFIQWDIHKSGQKVSEYSLPSDATGPFMLSGYSGYKQVQFPRGRLFAFDSEGKYMLTCSSTGGVIYKLNSDGSTLENCLSLGGHRAPVVTVDWSTAVECGTCLTASMDGKIKLTTLLAQKS

Wdr91

WD repeat-containing protein 91

748 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (By similarity). May play a role in meiosis (PubMed:27346680).

Belongs to the WD repeat WDR91 family.

83.421 kDa

MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTINKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIISLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQQEEEAAALVQHKLPPYVSSMDRLGDSELALVCSQRPASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQAQSSAKKDSFSSQATKGKDSVPGAKDGKSLLSGPVPGEASWTHQRQRRLQDHGKERRELLSTSSSQSQCAERKPEVSGAEAEPCLELHMGPVEVLARVSTAGSEGDRPEQPFIVLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNGASFVCSAAAPSLTSQTDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIHKSGLKVSESNLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGLIYKLGSEEKVLENCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKL

WDR91

WD repeat-containing protein 91

747 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).

Belongs to the WD repeat WDR91 family.

83.344 kDa

MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDSELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSSAKKESFGGQGTKGKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASGPEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKA

Wdr91

WD repeat-containing protein 91

747 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.

Belongs to the WD repeat WDR91 family.

83.146 kDa

MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTINKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIISLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEVHRLKKEEQQQEEAAALVQHKLPPYVSSMDRLGDSELALVCSQRPASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQAQSSAKKDTFSSQATKGKDPVPGAKDGKSLLSGPVPGEASWTHQRQRRLQDHGKERRELLSTSSSQTQCAEKKLEGSGPEAELCLDLHMGPVEALARVSTAGSEGDRPEQPFIVLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNGASFVCSAAAPSLTSQPDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHGCAMSWKAHCGEVYSVEFSYDENAVNSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGLIYKLGSEEKVLENCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKL

WDR91

WD repeat-containing protein 91

746 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.

Belongs to the WD repeat WDR91 family.

83.157 kDa

MAEAVERTDEMVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWNYLERRLFSRLEDVYRPTINKLKTSLFRFYLVYTIQTNRSDKAQEFFAKQASELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDSELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQTQSSAKKESFGSQTTKGREPAGAPKDGKSLFGGLAPGESSWSQHRQRRLQDHGKERKELLSMTLQCAEKKPEAGGPEAEPCPEPHVEALETLTRVPTAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPSGASFVCSAAASSLTAHVDVLAPDIGSRGTNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYGLPADATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDDKVLESCVSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKV

wdr91

WD repeat-containing protein 91

724 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.

Belongs to the WD repeat WDR91 family.

80.767 kDa

MASAVERTDDLVREYLIYRGFTSTLKHLDSEIKTDKEKGFRVDKIMDQLQLLIQSCDLTGLKEYWANLERRLFCRLEDVYKPTVSKLRTSLYRFYLIHTVQVKNVEKTQEFFQKQALELQAQAEWRDWFSLPFIPAPEQNPSFSAYFSRQWADTFLVSLHNFLSVLFQCMPLPALLSFDSEVQRITSLQEDNEQLRQTVFALQGESRLKKDEQMVHHKLPPYVQHMDRLGDTELDLVSSQRNVNMATPSRNFFSTFLPQGRRAPGRTAPGPQSSPTQSALGRKDAAASMQSSKAKDKEVKPPSVSSMTAELSTSHPRQRRHQDHEKERKELFSKHAAQGSEKKTDSDPDTQTEAPPDQTDSANQTRVCDVGGAGAEQPFIKLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVVKVWAFNPIMQTKATIMSKSPLLSLEWAAKPDRLLLLGSGVGTVKLYDTDAKKCLYEMTIDDVHPRILSLACSPSGTSFVCSAAAHSGAVMESEPRGSAPVSGQLLLWDTKTVKQQLQFALEPGPVAINCTAFNHNGNLLVTGAADGIIRLFDMQRYESALSWKAHDGEVYSVEFSYDENTVFSIGEDGKFVQWNIHRCGVKQSEYSLSQDAVGPFVLSGYSGYKQVQVPRGRLFAFDSEGQHVLTCSSTGGNIYRLNKAEAGLESVLSLAGHKAPVVTVDWCSAMDCGTCLTASMDGKIKLSTLLAQKP

WDR91

WD repeat-containing protein 91

712 amino acids

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.

Belongs to the WD repeat WDR91 family.

79.269 kDa

MIFHCEVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLHNFLSVLFQCMPVPVILNFDAECRRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEEEEALVQHKLPPYVSNMDRLGDSELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQAQSSAKKESFGGQGTKGKDPTSGAKDGKGLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEKKPEASGPEAEPCPELHTEPVEPLTRTSLAGPEGGGVRPEQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKA