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WDR5

Gene
wdr5
Protein
WD repeat-containing protein 5 homolog
Organism
Dictyostelium discoideum
Length
335 amino acids
Similarity
Belongs to the WD repeat WDR5/wds family.
Mass
37.37 kDa
Sequence
MESGPASMSSSSSYLYQEQQQQQPQQTESIPQTPNYILKYTLKGHLKSISSVKFSPDGKWLASASADKTIKIWGAYDGKFERTLEGHKEGISDIAWSQDSKLICSASDDKTIKIWDVESGKMVKTLKGHKEYVFGVSFNPQSNLIVSGSFDENVRIWDVNTGECTKMISAHSDPVTGVHFNRDGTLVVSGSYDGTVRIWDTTTGQLLNTISTEDGKEVSFVKFSPNGKFVLAGTLDNTLRLWSYNNNKKCLKTYTGHKNEKYCIFSTFSVTCGKWIVTGSEDNLIYIYNLQTREIVQTLAGHEDVVLTVACHPTENIIASGALEKDRSVKIWKHM
Protein
WD repeat-containing protein 5 homolog: wdr5

Gene
WDR5
Protein
WD repeat-containing protein 5
Organism
Bos taurus
Length
334 amino acids
Function
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
Similarity
Belongs to the WD repeat WDR5/wds family.
Mass
36.516 kDa
Sequence
MATGEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Protein
WD repeat-containing protein 5: WDR5

Gene
WDR5
Protein
WD repeat-containing protein 5
Organism
Homo sapiens
Length
334 amino acids
Function
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
Similarity
Belongs to the WD repeat WDR5/wds family.
Mass
36.588 kDa
Sequence
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Protein
WD repeat-containing protein 5: WDR5

Gene
Wdr5
Protein
WD repeat-containing protein 5
Organism
Mus musculus
Length
334 amino acids
Function
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
Similarity
Belongs to the WD repeat WDR5/wds family.
Mass
36.588 kDa
Sequence
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Protein
WD repeat-containing protein 5: Wdr5

Gene
Wdr5
Protein
WD repeat-containing protein 5
Organism
Rattus norvegicus
Length
334 amino acids
Function
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
Similarity
Belongs to the WD repeat WDR5/wds family.
Mass
36.588 kDa
Sequence
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Protein
WD repeat-containing protein 5: Wdr5

Gene
wdr5
Protein
WD repeat-containing protein 5
Organism
Xenopus tropicalis
Length
334 amino acids
Function
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
Similarity
Belongs to the WD repeat WDR5/wds family.
Mass
36.685 kDa
Sequence
MATEEKKPETEASKTQSTPSSSNNQSKPAPVKPNYTLKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTCHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEVVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Protein
WD repeat-containing protein 5: wdr5