washc1

WASH complex subunit 1

481 amino acids

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting.

Belongs to the WASH1 family.

52.112 kDa

MVRMTQKRYLEGQVYSVPLIQPDLRREEAVHQITDALQYLEMISTDIFTRVSESVEKNRAHLQSVTDRIKLAQARVQKIKGSKKATKVFSSAKYPAPEKLQDYSSIFTGAVDPASQKRPRIKVQSKLRPLDDKAQQEKLMYLPVCVNTKKRSEDETEEGLGSLPRNVNSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHTTLETEKEDKPFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPSYLPDLPGIADDLMYSADLGPGFAPSVPASNSIPELPSFGTDHDESSGSDSQFKLEAPPPPPPPPPPPPEPTHVPVPPPGTSAAPPPPPPPPPMTADNTDASSPAPPTGTVKGAPSEVVQPSNGRASLLESIRNAGGIGKANLRNVKERKMEKKKQKEQEQVGATVSGGDLMSDLFNKLAMRRKGISGKGPAGQGDSSEAPASSGGAFARMSDVIPPLPAPQQSAADDEDDWEA

WASHC1

WASH complex subunit 1

476 amino acids

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting.

Belongs to the WASH1 family.

51.683 kDa

MTTVAQKHFLEGQTYSVPLIQPDLRREEAVQQVADALQYLQKVSGDIFNRISQRVETSRAQLQAISERVTLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYCSIFAGAEDPSKQKWPRHKIQSKHRMLDEKSLQEKLKYFPVCVNTKIHQEDDAEEGLGSLPRNISSLSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVALETETEEKLFDAPLSITERGQLDRQVAENYFYVPDLGQVPEIDVPSYLPDLPGIAADLMYSADLGPGIAPSAPSSAIPELPTFSTESVEPSQADLQDPGLLPPPPPPPPPPPPVMPTTVPPPPPLPQPTAPSEPARTASEDSSKTVPAASVQGAPKEVVNPSTGRASLLESIRQAGGIGKANLRSVKERKLEKKKQKEQEQVRATGQGGDLMSDLFNKLVLRRKGISGKGPGASANPDAPGSPAGAFARMSDSIPPLPPPQQPPGEEDEDDWES

Washc1

WASH complex subunit 1

475 amino acids

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875). Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting (By similarity). Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function (PubMed:23275443). In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (PubMed:24886983). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (PubMed:19732055). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (PubMed:23974797).

Belongs to the WASH1 family.

51.659 kDa

MTPVKTQCSLAGQLYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISRRVELSRRQLQAISERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPEHLQEYGSIFTGALDPGLQRRPRYRIQSKHRPLDERALQEKLKYFPVCVNTKSEPEDEAEEGLGGLPSNISSISSLLLFNTTENLYKKYVFLDPLAGAVTKTHTMLGTEEEKLFDAPLSISKREQLERQAPENYFYVPDLGQVPEIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPAFHTEVAEPLQPELENEVLLAAPPPPPPPPPPPPPAPTALVSTPQPPMFPDMATAAGQVAREEDSSSSMAHTASVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLVMRRKGISGKGPSTGTSEGPGGAFSRMSDSIPPLPPPQQPAGDEDEEDWES

Washc1

WASH complex subunit 1

475 amino acids

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.

Belongs to the WASH1 family.

51.327 kDa

MTAVKTQHSLAGQVYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISQRVELSRRQLQAIGERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPEHLQEYNSVFTGALDPGLQRRPRYRIQSKHRPLDERALQEKLKYFPVCVSTKSEPEDEAEEGLGGLPSNISSISSLLLFNTTENLYKKYVFLDPLAGAVTKTHTMLGTEEEKLFDAPLSISKREQLEQPAPENYFYVPGLGQVPEIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPAFHTEVAEPFQPEREDGALLAPPPPPPPPPPPPPPAPTAVVSAPQPPMSPDVVTVTGKVAREEDSGSGEAHSASVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLVMRRKGISGKGPGTGTSEGPGGAFSRMSDSIPPLPPPQQPAGDEDEDDWES

washc1

WASH complex subunit 1

472 amino acids

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting.

Belongs to the WASH1 family.

51.124 kDa

MPQNRSVESQAYSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRDQLQRINGRLSLAQAKIERLKGSKKAIKVFSSAKYPAPDRLQEYSSIFAGAKDGWSAKKQRHKIQSKHRPLDEQAVQEKLKYFPVCVNTRGQDEESAEEGLGSLPRNINSVSSLLLFNTTENLYKKYVLLDPLAGVVTRTNPALEGEDEEKLFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPYSLPDLLGVADDLMYSADLGPGIAPSAPGVPIPELPTFTTEDITENSITDRQDGRLLPPPPPPPPPPPPPPPPEPSALSPPAPPPPPLSIPAPAKKGGSDPGDQGAVQGAPKEVVNPSNGRASLLESIRQAGGIGKANLRNVKEKKLEKKKMKEQEQVGATGGGGDLMSDLFNKLAMRRKGISGKVPAAGEASGDGPTGAFARISDTIPPLPPPHQASGDGDEDDWES

washc1

WASH complex subunit 1

472 amino acids

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting.

Belongs to the WASH1 family.

51.236 kDa

MPQNRSMESQAYSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRGQLQRINGRLSLAQAKIERLKGIKKAIKVFSSAKYPAPEHLQEYSSVFAGAEDGWLAKKLRHKIQSKHRPLDEQAVQEKLKYFPVCVNTRGQDEESAEEGLGSLPRNISSVSSLLLFNTTENLYKKYVFLDPLAGVVTRTNPALEGEDEEKLFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPYSLPDLPGVADDLMYSADLGPGIAPSAPGVPIPELPTFITEDITENSRTDSQDGRLLPPPPPPPPPPPPPPPPEPSVLSPPTSLAPPLPIPAPARVGSSDVGDPGSLQGAPKEVVNPSDGRASLLESIRQAGGIGKAKLRNVKEKKLEKKKMKEQEQVRATGGGGDLMSDLFNKLAMRRKGISGKGPAAGEASGDGPTGAFARISDTIPPLPPPDQASGDGDEEDWES

WASHC1

WASH complex subunit 1

471 amino acids

Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).

Belongs to the WASH1 family.

50.773 kDa

MTPTGTQHSLAGQTYAVPLIQPDLRREEAIQQVADALQYLQKVSGDIFSRISQRVELSRSQLQAIGERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFMGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKFFPVCVNTKPEPEDEAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISRREQLERQVPENYFYVPDLGQVPDIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPTFHTEVAQPFKPDLEDGVLTARPPPPPPPPPPPAPAVLMSVPPPPPPPQAPPGQPAKGDDSGGASPSAPVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLAMRRKGISGKGPGSGASEGPGGAFARMSDSIPPLPPPQQPPGEEDEDDWES

WASHC1

WASH complex subunit 1

465 amino acids

Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting (PubMed:20498093). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).

Belongs to the WASH1 family.

50.328 kDa

MTPVRMQHSLAGQTYAVPFIQPDLRREEAVQQMADALQYLQKVSGDIFSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPGRLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIHVPSYLPDLPGIANDLMYSADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKQQQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFVRVSDSIPPLPPPQQPQAEEDEDDWES