VTH2

Gene

VTH2

Protein

VPS10 homolog 2

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

1549 amino acids

Function

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.

Similarity

Belongs to the VPS10-related sortilin family.

Mass

174.402 kDa

Sequence

MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPISEKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSGLMYVGREIYTTNDGVSFSQVKPSFGKIDGHISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTGSTIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPSKFYYSLDQGKTWGEYDLIMPIYPYRLVSTISDGSGSKFILTGTSITEDPIFITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPDGFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTSRTDLLGASNIPDALPARSASHESDLAAARSEDK

Protein

VPS10 homolog 2: VTH2

Gene

VTH2

Protein

VPS10 homolog 2

Organism

Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)

Length

1495 amino acids

Function

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.

Similarity

Belongs to the VPS10-related sortilin family.

Mass

168.533 kDa

Sequence

MALFRALYIIWVFLLIPLFNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRADEDSVEISFDAGENWKTIDGIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPISEKASNYFCGITTHPIKKKHLIIRCDLLTINDSGVMHVGREIYTTNDGVSFSQVKPSFGKIDGHISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTGSTIDKSELILSADGGETFKELVQFKDKVVRRYEILKYHVVVLTQDDMYNEMSSMDIWISNDVCTFQIAHTPTKIRHVNMGQIHEDSIGRIVLSVSRERDDEDSNQPGAAEVLISDSEGLKFLPIKWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWSNLKVVDRENVDSFGCDVTKPERCSLHTYFYDLRNLRPSAGIMMISGIVGDGSVYDWNEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPSKFYYSLDQGKTWGEYDLIMPIYPYRLISTISDGSGSKFILTGTSITDDPISITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKDKSVLVEPLQLIKGDKCKTPMKIEPVDIPCDEIPEEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEVVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDKKTVFENIIGYLSTGGYIIVAVPHENNELRAYVTNDGAEFAEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGEHKGDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFLCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDVITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGKKRADFKYSPLGSRTDCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCSCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYPINTGAYALVFVTILLVIFFAAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDAFQRAKAGTAQLSCFKI

Protein

VPS10 homolog 2: VTH2