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VTA1

Gene
vta1
Protein
Vacuolar protein sorting-associated protein VTA1 homolog
Organism
Dictyostelium discoideum
Length
550 amino acids
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins. Thought to be a cofactor of VPS4, which catalyzes the disassembly of membrane-associated ESCRT-III (By similarity).
Similarity
Belongs to the VTA1 family.
Mass
61.198 kDa
Sequence
MDLASLPPALKPIIPYLKQSQQLEKHDLLMAYYCRVHAIQMAMDIKQKMGASGSFLSIPIVKILDQGDADKAKLGSRLDEEDEAKYVEAFAMKAFSFADTQDRAGKANKATSTTFYSAFLFFNVLEHMGEVSEEVKLKKKYASWRSVDINTAIKNGVAPSPPPSIDQNEEGGASGETEEDAQLKQLEMELNLAKATLQQDNNNNNNMSSSTIITTNSVSEGMSSSLSFPSFPSIPNNNNNNNNTTPSFPSFPSFPSPTNSDNNSNNNKPAFPSFPSFPSPPTTTNSDSAPSFPKFPSTPSPTNSSSNNSQQPSFPSFPSFTSPTNSNNNNNNSQQPSFPTFPNSTNQKRQVFESDEEEEQEEVEDYSEKQQQKSTSSSFPKFPSNSHNNEYNQPPPPAYEFKQSPPQQHKQSPPQQHHNSHDNEALIKYQQQVAQQNLTIQKQKHQNQMLQDEVEQKQQQIQLQQQQLQQQQQQIQLLQKQIQQQQKQLMSGGGGGGNMSMNLNHTPSDTDKASAEKYSKWVISSLQFDDVPSAVKNAKLSLKYLTGEDS

Gene
VTA1
Protein
Vacuolar protein sorting-associated protein VTA1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
330 amino acids
Function
Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.
Similarity
Belongs to the VTA1 family.
Mass
37.316 kDa
Sequence
MASNAARVVATAKDFDKVGLGIIGYYLQLYAVELILSEEDRSQEMTALATELLDTIEAFKKEIGGESEAEDSDKSLHVMNTLIHDQEKAKIYMLNFTMSLYNEKLKQLKDGPWDVMLKRSLWCCIDLFSCILHLWKENISETSTNSLQKRIKYCKIYLSKLAKGEIGSSDEKTLDYADFADDSEEIKDEDVDHQTSDLENNNNDKVEGLAPKDQTTSYEPVDEVPEFIDDADSVNEEEQTVDKNEDAITKDEQQVVKKEVDLTRPSAPSEPAAAEHKSYTKDELTKIMDRASKIEQIQKLAKYAISALNYEDLPTAKDELTKALDLLNSI

Gene
Vta1
Protein
Vacuolar protein sorting-associated protein VTA1 homolog
Organism
Mus musculus
Length
309 amino acids
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR.
Similarity
Belongs to the VTA1 family.
Mass
33.913 kDa
Sequence
MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAVTQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEENDVEENEDVGATSLPTQPPQPSSSSAYDPSNLAPGSYSGIQIPPGAHAPANTPAEVPHSTGVTSNAVQPSPQTVPAAPAVDPDLYTASQGDIRLTPEDFARAQKYCKYAGSALQYEDVGTAVQNLQKALRLLTTGRE

Gene
VTA1
Protein
Vacuolar protein sorting-associated protein VTA1 homolog
Organism
Bos taurus
Length
307 amino acids
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Similarity
Belongs to the VTA1 family.
Mass
34.016 kDa
Sequence
MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNVDVEEYEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGVTSNTIQPTPQTIPAIDPALFSTVSQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE

Gene
VTA1
Protein
Vacuolar protein sorting-associated protein VTA1 homolog
Organism
Homo sapiens
Length
307 amino acids
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.
Similarity
Belongs to the VTA1 family.
Mass
33.879 kDa
Sequence
MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAITQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAASLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDVRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE

Gene
VTA1
Protein
Vacuolar protein sorting-associated protein VTA1 homolog
Organism
Pongo abelii
Length
307 amino acids
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
Similarity
Belongs to the VTA1 family.
Mass
33.879 kDa
Sequence
MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAITQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDVEENEDAGAASLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE