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VRK1

Gene
Vrk1
Protein
Serine/threonine-protein kinase VRK1
Organism
Mus musculus
Length
440 amino acids
Function
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity).
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Mass
49.741 kDa
Sequence
MPRVKAAQAGRPGPAKRRLAEQFAAGEVLTDMSRKEWKLGLPIGQGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSHKNPDQVYLVDYGLAYRYCPDGVHKEYKEDPKRCHDGTLEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRDSKIRYRDNVAALMEKCFPEKNKPGEIAKYMESVKLLEYTEKPLYQNLRDILLQGLKAIGSKDDGKLDFSAVENGSVKTRPASKKRKKEAEESAVCAVEDMECSDTQVQEAAQTRSVESQGAIHGSMSQPAAGCSSSDSSRRQQHLGLEQDMLRLDRRGSRTRKKAQK

Gene
vrk1
Protein
Serine/threonine-protein kinase VRK1
Organism
Danio rerio
Length
425 amino acids
Function
Serine/threonine kinase involved in Golgi disassembly during the cell cycle.
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Mass
47.771 kDa
Sequence
MPPKKADGVKKARAPAKRKLAEEFPSGEVLTDNAKKKWKLGSAVGQGGFGLLYLANEDSSGPVTADAPYVIKVEPSDNGPLFSELKFYMRAAKPDLIGAWMKSKKMEYLGVPKYWGSGFHEKNGKRYRFMVMDRFGTDLQKLFEGNGKKFSRKLVLQLGLRLLDILEYIHDHEYVHADIKASNLLLSYTNPNQVFLVDYGLAYRYAPEGVPKEYKEDPKRCHDGTIEFTSIDAHKGVSPSRRADLEIMGYCMIQWLCSRLPWEDKLQDPLYVRDSKLRCRDNIDEFLKSCFASGNIPAEMGKFMQEVKVLGYTDRPDYDKLRGILQQGLKSIGSTDDKKLDFGVATNSTSLPSVKTPKRKKAEEKGQSADETDSTPAKKRRAPQKKEVNGAKKTASPAKRPVKKETQASSEPAVKKSRGRPKKNS

Gene
VRK1
Protein
Serine/threonine-protein kinase VRK1
Organism
Bos taurus
Length
396 amino acids
Function
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity).
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Mass
45.358 kDa
Sequence
MPRVKAAQAGRQGPAKRRLAEHFAAGEIITDMNKKEWKLGSPIGQGGFGCIYLADMNSSKSVGNDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIIDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPEGTHKEYKEDPKRCHDGTVEFTSIDAHNGVAPSRRGDLEILGYCMIQWLSGHLPWEDNLKDPNYVRDSKIRYRENIASLMDKCFPEKNKPDEIAKYMETVKLLDYVEKPLYQKLRDILLQGLKAIGSKDDGKLDLTVVENGSLKAKPVAKKRKKEAEESVESSVEDMECSDKQTEEATQTRSKTRKRVQK

Gene
VRK1
Protein
Serine/threonine-protein kinase VRK1
Organism
Homo sapiens
Length
396 amino acids
Function
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Similarity
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Mass
45.476 kDa
Sequence
MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK