Protein
Vacuolar protein sorting-associated protein 54
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton (By similarity).
Similarity
Belongs to the VPS54 family.
Sequence
MERISSAPSISLGYPPTESSAHLAPSFSDSATSTLSFKSLLEDPVNPIRPVYTPTRTEITPVTLSPIPITPVREFQPYLHEISQEYARYSKQKRASLRRYLEKHGKLEGSMKESSINGSLLRRSSVSTILRPASESSYPNSNSETITYDIDDNVNPSSSLVDNFSISSVPSVFFQSDFNLDDPQIFDVVSEHIDITQTSDAPNSNRNLLLNNSMLQEKISWYLDTVELHLLQEIENASDSFPMIIDNLKQLKKETRDNVEETKHLLEKLTEVNVMCDRHMDAISSEELACHQLTQLKKVVQTLEDIYSEHKKVSEDVKDQRFLEAINGINSIVTQLKKKSTELNVDLLSLPSVKSLREEHKVLYHTVSQSVVQQFSKFLTSDMHKFSTILDSNELKDIYLSKNRLIPSVTKSLPSAMEFDADFLHEVDVCIDCLTLTDSLQAALTLYKTAVFEAFENLAQQYFTDGVEMRSVRKSSDLRRSLSAASLSSLSDSSRRSSSAANPFQSMSITEFAEMLTNIYFSSLECLRRIRSQIKVLIDILSKKDTKQYHLSVILNDLMATSSDVVTQQVTTINNLRFRVLDTYPPNNVIYLFSLHIIFHNELESLCGITQSSFIPTIMRQLLDWFKNFQRYSTQKLASSFERELWEAIPVEPSCQDLANRVFECSGNTPVEWTRLLSPEAEKEDENHRVHHVKVSEDCTATVSFGKQSLHIVRSSVTLLETLDDYGKLLAHFSRLAPEFQTGMLDMFRTLNSRVYQLILGAGTVRSSGLSKVLGKHIALASQTIALFQLSLNSMCRYLSRVTGTRLTNETNKLDQDFTVHHLQIHDKFVSLMRERVAISCSQIASLSWDIDSPHGYIIDLSKSLIKLYKVLHRYSQRDCVEVIPDVIRMFEDRLQLELTDIARNPSKWPGVRIDLSYFYDMMASKCGYAGDRTLLEKFERTPEQQEAA