VPS3

Vacuolar protein sorting-associated protein 3

1011 amino acids

Required for sorting and processing of soluble vacuolar proteins, integrity of vacuolar morphology, efficient segregation of vacuolar material into the bud during the cell cycle, acidification of the vacuolar lumen, and assembly of the vacuolar H(+)-ATPase.

Belongs to the VPS3 family.

116.922 kDa

MVKKKTNNDKGKEVKENEGKLDIDSESSPHERENDKKKTEDDSLRATESEETNTHNANPNETVRADKFSQEESRPIEDSPHTDKNTAQESCQPSSAEDNVINTDITSLNEKTSTNDEQEKGLPLKISEGPFTISTLLDNVPSDLIYTCCEAYENHIFLGTTTGDLLHYFELERGNYMLVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVLFILPEFAPRPNTTRLKGISDVVICNFSRSSKAYRIYAFHAEGVRLLKISADSLVLTKAFNFKLIDKACAHEETLMVSKLNSYELINLKSSQVIPLFRISETDEDLEPIITSFNEQSEFLVCSGGGSYDSGAMALVVNHHGDIIKGTIVLKNYPRNVIVEFPYIIAESAFQSVDIYSALPSEKSQLLQSITTSGSDLKISKSDNVFTNTNNSEEFKEKIFNKLRLEPLTHSDNKFRIERERAFVEESYEEKTSLIVYNNLGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAKKDLTKFEHIEAKYLMSLLLFLMTLHYDHIEDEVMKKWCDFSDKVDIRILFYMFGWKVYSEIWCFHGLINIVERLKSLKLTNKCENILKMLLMMKNELKKKNKTGLLTNDFDDIMKTIDITLFKLRLEKKETITVDMFERESYDEIIREINLHDDKLPRIELLIEIYKEKGEYLKALNLLREAGDYISLVSFIEENLKKLPEDYIKERIADDLLLTLKQGDENTEECAIKKVLKILDMACINKNDFLNKIPAEETSLKVSFIEQLGVQNSNDSKFLFNYYLAKLREIINQSNIWSILGDFIKEYKDDFAYDKTDITNFIHIKLKHSLQCENFSKYYEKCENLKSENEKDDEFINFTFDEISKIDKEHILTLLFFPNELTNWVSSEELLKIYLSFNDFRSVEKYIGKQNLVAVMKQYLDISSLNYSVELVTNLLQRNFELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKKEESNLRKCLLKNQISISDELSRNFDSQG

VPS3

Vacuolar sorting protein 3

984 amino acids

Essential protein required during embryogenesis. Believed to act as a component of the putative class C core vacuole/endosome tethering (CORVET) endosomal tethering complexes. CORVET is required for vacuolar transport of SYP22. Involved in root development (PubMed:29463724). Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway (By similarity).

Belongs to the TRAP1 family.

109.906 kDa

MSKSRAVVELTARFDLGGDDKIRALSLSPISDSQTLVYLGTYSGSLILLSLDTLTNTVSRLASVSLSPSPVESIFVLGEERGRVLALCNGYLFLLDSLLSQPAKRLGGLLKGINVIAKRVRGRDSSSTDLLPSEISTDSSSSKKFLQLLGAGNLVSDVRGNDSRHERVQQGHYVFAVAIGERMLLIELQCAEKEGLSGSFVVLKEILGIGGIKTLVWLDDYVIAGTVKGYSLISCVTGLSGVIFTLPDVSGPPLLKLLCKEWKVLLLVDNVGVVVDTNGQPIGGSLVFRRRPDSVGELSFYLVTVGDGKMEIHQKKSGACVQSVSFGPQGCGPSLLAADEAGDGNLLVVTTLSKLIFYRRVPYEEQIKDLLRKKRYRETISLVEELDSQGEISKDMLSFLHAQIGYLLLFDLRFEEAVNQFLKSEKMEPSEVFPFIMRDPNRWSLVVPRNRYWGLHPPPAPFEDVVDNGLMAIQRANFLRKAGMDTPVDEEFFSDPPSRADLLDSAIKNITRYLEISREKGLTLPVREGIDTLLMLLYRALNRVEDMENLASSGNNCVVEELETLLTESGHLRTLAFLYATKGMGAKALAIWRLFTKNYSSGLWQDSDDLVPYLHDNELIRLSGKEAAAAEAARILEEPCDPELALQHLSWIADVNPLFAIQVLTSDKRTEELSPEQVIQAIDPKKVEIIQRYFQWLIEERDYTDPQLHTSYALSLARSALECVEVQNGIQEADVPNGSEAHDSNVGSISLFEVDVRERLQAFLQSSDLYDPEEILELVEGSELWLEKAILYRRIGKETLVLQILALKLEDCAAAEQYCVEIGRPDAFMQLLDMYLDPQNGKEPMFKAAVRLLHNHGESLDPLQVLDKLSPDMPLKLASDTILRMLRARVHHHRQGQIVHNISRALDVDSRLARLEERSRHMQINDESLCDSCYARLGTKLFAMYPDDTIVCYKCYRRLGESKSVTGRDFKRDVLIKPGWLVNR

vps3

Vacuolar protein sorting-associated protein 3

910 amino acids

Required for sorting and processing of soluble vacuolar proteins.

Belongs to the VPS3 family.

104.581 kDa

MSDIELHESAIPKELDSPVTTIALYNNHLYFGTEGGDVFLYNFSNFQLNESPELVKKISLVSKSRVNRILAMPFLGAVFIHHGSFAEVYKEDDLTQLYPSISFKGLVEFCHPGQRIDEKSTYLIVTNTHLKLISFQKDGIILVKNELKYPNIQTARVNGHIVCLVTENSFELLDILTFDTTPLFPIIKYDSENNGLMYKPMIVLHSNEFLLITGSPKDAIGLFVDSQGNVTRSTLTFSFYPKHVFSTSHYVFAISSSSLQIIDINTLSLVKSINLKDDESFSFISRLTSVHFCDRQIFSKFSAVNTASTSKTSDTIERASFSKPSFIFLTNKSWGFGAEAHFMNKLEFSITIGDIEAPLRRVSKRLRNPKKYGITNDVAYLQSAYLEQISALQYWKQGQYENSLSLLETSKIDPRVVISLYPDLYHSELSYIAFQGVISFRKSILSVDDTVANVLKSNELFRDTDQYTQRQMIEITKENAYIMLMRYLKNYKKNTSISEYLLSSQRDVMLAVEHSLLLLYLNMDDLAAGTKNAKELLESGLTGVEDIKDVLIQKKEYYLLSVLLATVRDHDGVLQTWKKLITGDYEDRRFNDGLIKIREYLVNDIEPSTFWEFTTWLCKHDATEGTRVLLDKTVSGSISAEDVLEHLDSSQDDVLIDYLVKSNSVTHRALLLKLCVNKLLGSLLDHNDFKNRLETAIETFRELPCMEKPTYAQYLEQLWGDMSDFSTHLSFYYLCSINLMENVEEESIDKIKDILFDIHVDNLYLFPQLEHSFYKRKKNYEKALSVLVTNIHDYKGGEAYCLQIDDVYPQCWCNLLEKCISTGDGCSDFIKELLYRRPFSYTLSYVCEQIPDHWNLNLLADFLCILQKRNAERLNESQTRLTLEKSLSQNLEELFMAINRRNVALGKNEI