VP30

Minor nucleoprotein VP30

288 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

32.107 kDa

MERGRERGRSRNSRADQQNSTGPQFRTRSISRDKTTTDYRSSRSTSQVRVPTVFHKKGTGTLTVPPAPKDVCPTLRKGFLCDSNFCKKDHQLESLTDRELLLLIARKTCGSTDSSLNIAAPKDLRLANPTADDFKQDGSPKLTLKLLVETAEFWANQNINEVDDAKLRALLTLSAVLVRKFSKSQLSQLCESHLRRENLGQDQAESVLEVYQRLHSDKGGAFEAALWQQWDRQSLTMFISAFLHVALQLSCESSTVVISGLRLLAPPSVNEGLPPAPGEYTWSEDSTT

VP30

Minor nucleoprotein VP30

288 amino acids

Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. In turn, clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists also stop-start transcription at gene junctions to promote transcription of downstream genes.

Belongs to the filoviridae minor nucleoprotein VP30 family.

32.521 kDa

MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRSASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLLLIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIRTIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDKGGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTNPGTCSWSDEGTP

VP30

Hexameric zinc-finger protein VP30

288 amino acids

Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. In turn, clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists also stop-start transcription at gene junctions to promote transcription of downstream genes.

Belongs to the filoviridae minor nucleoprotein VP30 family.

32.521 kDa

MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRSASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLLLIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIRTIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDKGGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTNPGTCSWSDEGTP

VP30

Minor nucleoprotein VP30

287 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

32.389 kDa

MEHSRERGRSSNMRHNSREPYENPSRSRSLSRDPNQVDRRQPRSASQIRVPNLFHRKKTDALIVPPAPKDICPTLKKGFLCDSKFCKKDHQLDSLNDHELLLLIARRTCGIIESNSQITSPKDMRLANPTAEDFSQGNSPKLTLAVLLQIAEHWATRDLRQIEDSKLRALLTLCAVLTRKFSKSQLGLLCETHLRHEGLGQDQADSVLEVYQRLHSDKGGNFEAALWQQWDRQSLIMFISAFLNIALQTPCESSSVVVSGLATLYPAQDNSTPSEATNDTTWSSTVE

VP30

Minor nucleoprotein VP30

287 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

32.401 kDa

MEHSRERGRSSNMRHNSREPYENPSRSRSLSRDPNQVDRRQPRSASQIRVPNLFHRKKTDALIVPPAPKDICPTLKKGFLCDSKFCKKDHQLDSLNDHELLLLIARRTCGIIESNSQITSPKDMRLANPTAEDFSQGNSPKLTLAVLLQIAEHWATRDLRQIEDSKLRALLTLCAVLTRKFSKSQLGLLCETHLRHEGLGQDQADSVLEVYQRLHSDKGGNFEAALWQQWDRQSLIMFISAFLNIALQIPCESSSVVVSGLATLYPAQDNSTPSEATNDTTWSSTVE

VP30

Minor nucleoprotein VP30

281 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

31.594 kDa

MQQPRGRSRTRNHQATPSIYHETQLPSKPHYTNHHPRARSMSSTRSSAESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCTDPTCNRDHDLDNLTNRELLLLMARKMLPNTDKTFRSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILSYLHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHINHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQSQGKGQ

VP30

Minor nucleoprotein VP30

281 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

31.65 kDa

MQQPRGRSRTRNHQVTPTIYHETQLPSKPHYTNYHPRARSMSSTRSSAESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCADPTCNRDHDLDNLTNRELLLLMARKMLPNTDKTFRSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILSYLHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHMNHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQSQGKGQ

VP30

Minor nucleoprotein VP30

281 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

31.626 kDa

MQQPRGRSRTRNHQAIPSIYHETQLPSKPNYTNHHPRARSMSSTRSSTESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCTDLTCNRDHDLDNLTNRELLLLMARKMLPNTDKVFKSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILNYLHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHINHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQSQGKGQ

VP30

Minor nucleoprotein VP30

281 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

31.641 kDa

MQQPRGRSRTRNHQTASSIYHETQLPSKPHYTNHHPRARSMSSTRSSAESSPTNHIPRARPPPTFNLSKPPPPPKDMCRNMKIGLPCTDPTCNRDHDLDNLTNRELLLLMARKMLPNTDKTFRSLQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILNYLHRSDIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHINHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSTSVQASYDHFILPQSQSKGQ

VP30

Minor nucleoprotein VP30

281 amino acids

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene (By similarity).

Belongs to the filoviridae minor nucleoprotein VP30 family.

31.629 kDa

MQQPRGRSRNRSHQVALSTYHENQLPSKPQYINHHPRARSMSSTRSSTEGSPTNHASRARPLSTFNLSKPPPPPKDMCRNMKIGLPCTDPACNRDHDLDNLTNRELLLLMARKMLPNTDKAFKSQQDCGSPSLSKGLSKDKQEQAKDVLTLENLGHILNYLHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHINHENLPQDQNGVIKQTYTGIHLDKGGQFEAALWQGWDKKSISLFVQAALYVMNNIPCESSISVQASYDHFILPRNQGERQ