VP1

RNA-directed RNA polymerase

997 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

112.779 kDa

MSDIFNQQGLKSKFSNIVKNEGQGDSDIREVFNELARPQAEVGRDIEYSELSQALNDNSVKVFRPQPYDELVNIPFIEAASPRMMALYGELLDSKDVSLPVGSGLHIPTYKPGHEVTPPLLTLPNSLSYEYMHYIANSANDTWDKQIYETLKELLVAQATNRFSTGSLLGQVKRVAAGQDVAYGRKGHHKNKSFKEMGITPYRVMEWLDEYMPISDDEPEITLSNTLDWLVYTPEEAELMGVPDSLPDITQSSAAGLPWLGKKKGEVAVSALITANMLIKDVSQLLKENLFTGSNNPLDPKKEGVAEVTTKNPRRAADQFSRQVLDRIIKEYSYTMMGLLFPKGERYAIADHLTKTRNIWSASYVTHLIGSTISDQPAKRMLNVLTSTSRTPSLAKFSPTQGGMEALINIILNATDIVELVYADNAYIYYPNEDIWYSIDLTKGEANCTRDVAMTTAMYLLTRGWTSKQGTPIYNYTWAYLALYGIPYMTVDSISVLKNFQIKNPGQGSGNPWTFLNNHVLTTILMNKWSEIGKPQPSPDVIEKLASMTGIDFKVELVVTNFREKLIAASRHSIPTSNRVEPRTIVEMDMLGWDVTHTEFGFTPVLSKERLFKSIACPQPPSSTFQTSVAKQVHKYIQNVALLYVGAWAYPCIAQTIEGYALNHWNTINIMIRNKEYDLDKAIGKAVEASPFSEVISLLSLDRPMHEQNYAQVLYQQKTIEKKEAKPKVSNPLYKRDKETYHEYTTRMARMRINDDMVGPQWEPIINLVTKLYPREATGENQKSRESMTRVKIRGLLENMERQLESNGRSMDVWYNAYLTGKKPSGVDKKLATLLVLLAPKRTKKLPSGVYQKLLGYPPIDKSPVPSLTSDEAYLYDTNSLEYNRIAYVSKLNEDDITVYANKYMVYSSTLLSNLLPDKVDWPELRSMNVEGASDPYQVKGYKKKELKPRFGEEILDDEPTGKKSSSEKRRLQRKGQKAKLQRQAATGTTFVRKPLN

VP1

RNA-directed RNA polymerase

881 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

97.911 kDa

MSDIFNSPQARSTISAAFGIKPTAGQDVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKVLQPRSLPENEEYETDQILPDLAWMRQIEGAVLKPTLSLPIGDQEYFPKYYPTHRPSKEKPNAYPPDIALLKQMIYLFLQVPEANEGLKDEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLVLTGDVDGDFEVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLRELSTLLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTWLTKTRNIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSGNAATFINNHLLSTLVLDQWNLMRQPRPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVLLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNAGAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTVTSESLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAKAEAEKLHKSKPDDPDADWFERSETLSDLLEKADIASKVAHSALVETSDALEAVQSTSVYTPKYPEVKNPQTASNPVVGLHLPAKRATGVQAALLGAGTSRPMGMEAPTRSKNAVKMAKRRQRQKESRQQP

VP1

RNA-directed RNA polymerase

879 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

97.691 kDa

MSDVFNSPQARSKISAAFGIKPTAGQDVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKILQPRSLPENEEYETDQILPDLAWMRQIEGPVLKPTLSLPIGDQEYFPKYYPTHRPSKEKPNAYPPDIALLKQMIYLFLQVPEATDNLKDEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLVLTGDVDGEFEVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLRELSALLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTCCTKTRNKWSAQSSTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWIMAPDEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSGNAATFINNHLLSTLVLDQWNLMKQPSPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVPLAQPGYLSGGVEPEQPSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNASAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTVTPESLAELNRPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAMAEAEKLHKSKPDDPDADWFERSETLSDLLEKADIASKVAHSALVETSDALEAVQSTSVYTPKYPEVKNPQTASHPVVGLHLPAKRATGVQAALLGAGTSRPMGMEAPTRSKNAVKMAKRRQRQKESRQ

VP1

RNA-directed RNA polymerase

879 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

97.685 kDa

MSDVFNSPQARSTISAAFGIKPTAGQDVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKVLQPRSLPENEEYETDQILPDLAWMRQIEGAVLKPTLSLPIGDQEYFPKYYPTHRPSKEKPNAYPPDIALLKQMIYLFLQVPEANEGLKDEVTLLTQNIRDKAYGSGTYMGQANRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLVLTGDVDGDFEVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLRELSTLLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTWLTKTRNIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSGNAATFINNHLLSTLVLDQWNLMRQPRPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVLLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNAGAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTVTSESLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAKAEAEKLHKSKPDDPDADWFERSETLSDLLEKADIASKVAHSALVETSDALEAVQSTSVYTPKYPEVKNPQTASNPVVGLHLPAKRATGVQAALLGAGTSRPMGMEAPTRSKNAVKMAKRRQRQKESRQ

VP1

RNA-directed RNA polymerase

878 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

97.274 kDa

MSDVFNSPQARTKISAAFGIKPTAGQDVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKILQPRSLPENEEYETDQILPDLAWMRQIEGAVLKPTLSLHWGPRVLPKVLLNSPPEQGKAQCVPTRHCTTQADIYLFLQVPEATESLKDEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLVLTGDVDGDFEVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLRELSALLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTWLTKTRNIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWASFAMNIAPALVVDSSCLIMNLQIKSYGQGSGNAATFINNHLLSTLVLDQWNLMKQPNPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVPLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNASAARRHLEAKGFPLDEFLAEWSELSEFGETFEGFNIKLTVTRENLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAKAEAEKLHKSKPDDPDADWFERSETLSDLLEKADVASKVAHSALVETSDALEAVQSSSVYTPKYPEVKNPQTASNPVVGLHLPAKRATGVQAALLGAGTSRPMGMEAPTRSKNAVKMAKRAQRQKESRQ

VP1

RNA-directed RNA polymerase

867 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

96.792 kDa

MSDVFNTPHARRTITQALGLTNVSDRTQDWLLPEPWNPPMDPIKNSQEAAEYLQRNQYRMLKPRAIPENTPLDTSELFPHLAEFVGSGAFGTSTLVPAGSTEYIPRYYPTHKPEHNKPTPFGHYDVALLKQMTYQLTNGKDNPEEEGTTFRQFRDTIVEQQYGSGTSQGQLARLVAMKEVATGRNPNKSPKELGLSMEEIATMLEQTLPIGQPGGDEGWPSLTTTLSELLNPAEGMDYLPHITMKSSSGLPFIGKTKGETVTSALAICDTFLREVSECVKEGAMASDNQKLQKLLQDYWYLSCGLLFPKAERYEKKAWLTKTRNIWSAPFPTHLLLSTISWPIMNSSKNNILNVPECVSLYGFNPFSGGMDAVVTNILAQPDETLFLIYADNIYIYMDRTWFSIDLEKGEANATPEHAQAVSYYLLTRGWTQDDGSPAFNATWATIAMMIAPSLVVDSSCLFMNLQLKTYGQGSGNAWTFLINHTLSTILVGKWIEAGQPNPRSKEFMDLEAATGINFKIEREIEGLPTRLQEAMDKAVHTGFLGDGTTNPPEKEGPTVDLDLLGWSATYSRHMDMWVPVLDKERLLSSAAYPKGLENKDLKGKPGAEIAYKIVRNEALLMVGGWNYPLIARSLMANTSAARNNLRQKGVPLDTLTRDWEKMTEFSDIFEDLPIDTKLEVTSEFLQRLNLRGERKQPNVNKHHLRTKGLKKCVSALKQGACRNPTTVAGLKLTAYSKSRINKAKAVFDEINNLPKTESDDWSDRMDDADRLMKANNLYMREARSALEDVHNSLLALSGETVKAKTPQEKSTEKVSNPVVGYRLPAERATGVQHALLGVGVSRPSEGALTKNARKMKKRREKARGINH

VP1

RNA-directed RNA polymerase

845 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

94.467 kDa

MSDIFNSPQNKASILTALMKSTTGDVEDVLIPKRFRPAKDPLDSPQAAAQFLKDNKYRILRPRAIPTMVELETDAALPRLRQMVEDGKLKDTVSVPEGTTAFYPKYYPFHKPDHDEVGTFGAPDITLLKQLTFFLLENDFPTGPETLRQVREAIATLQYGSGSYSGQLNRLLAMKGVATGRNPNKTPKTVGYTNEQLAKLLEQTLPINTPKHEDPDLRWAPSWLINYTGDLSTDKSYLPHVTIKSSAGLPYIGKTKGDTTAEALVLADSFIRDLGRAATSADPEAGVKKTITDFWYLSCGLLFPKGERYTQVDWDKKTRNIWSAPYPTHLLLSMVSTPVMNESKLNITNTQTPSLYGFSPFHGGMDRIMTIIRDSLDNDEDLVMIYADNIYILQDNTWYSIDLEKGEANCTPQHMQAMMYYLLTRGWTNEDGSPRYNPTWATFAMNVAPSMVVDSSCLLMNLQLKTYGQGSGNAFTFLNNHLMSTIVVAEWVKAGKPNPMTKEFMDLEEKTGINFKIERELKNLRETIVEAVETAPQDGYLADGSDLPPIRPGKAVELDLLGWSAIYSRQMEMFVPVLENERLIASAAYPKGLENKALARKPGAEIAYQIVRYEAIRLVGGWNNPLLETAAKHMSLDKRKRLEVKGIDVTGFLDDWNNMSEFGGDLEGITLSEPLTNQTLVDINTPLDSFDPKARPQTPRSPKKTLDEVTTAITSGTYKDPKSAVWRLLDQRTKLRVSTLRDQALALKPASSSVDNWAEATEELAQQQQLLMKANNLLKSSLTETREALETIQSDKIIAGKSNPEKNPGTAANPVVGYGEFSEKIPLTPTQKKNAKRREKQRRNQ

VP1

RNA-directed RNA polymerase

844 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

94.089 kDa

MSDIFNSPQNKASILNALMKSTQGDVEDVLIPKRFRPAKDPLDSPQAAAAFLKEHKYRILRPRAIPTMVEIETDAALPRLAAMVDDGKLKEMVNVPEGTTAFYPKYYPFHRPDHDDVGTFGAPDITLLKQLTFFLLENDFPTGPETLRQVREAIATLQYGSGSYSGQLNRLLAMKGVATGRNPNKTPLAVGYTNEQMARLMEQTLPINPPKNEDPDLRWAPSWLIQYTGDASTDKSYLPHVTAKSSAGLPYIGKTKGDTTAEALVLADSFIRDLGKAATSADPGAAAKKVLSDFWYLSCGLLFPKGERYTQKDWDLKTRNIWSAPYPTHLLLSMVSSPVMDESKLNITNTQTPSLYGFSPFHGGINRIMTIIREHLDQEQDLVMIYADNIYILQDNTWYSIDLEKGEANCTPQHMQAMMYYRLTREWTNEDGSPRYNPTWATFAMYVGPSMVVDSTCLLMNLQLKTTGQGSGNAFTFLNNHLMSTIVVAEWHKAGRPNPMSKEFMDLEAKTGINFKIERELKDLRSIIMEAVDTAPLDGYLADGSDLPPRVPGKAVELDLLGWSAVYSRQLEMFVPVLENERLIASVAYPKGLENKSLARKPGAEIAYQIVRYEAIRLIGGWNNPLIETAAKHMSLDKRKRLEVKGIDVTGFLDDWNTMSEFGGDLEGISLTAPLTNQTLLDINTPETEFDVKDRPPTPRSPGKTLAEVTAAITSGTYKDPKSAVWRLLDQRTKLRVSTLRDHAHALKPAASTSDFWGDATEELAEQQQLLMKANNLLKSSLTEAREALETVQSDKIISGKTSPEKNPGTAANPVVAYGEFSEKIPLTPTQKKNAKRREKQRRN

VP1

Capsid protein VP1

735 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.

Belongs to the parvoviridae capsid protein family.

81.945 kDa

MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL

VP1

B3 domain-containing protein VP1

727 amino acids

Probable transcription factor that may participate in abscisic acid-regulated gene expression during seed development. May be required for seed maturation and dormancy induction.

75.802 kDa

MDASAGSSAPHSHGNPGKQGGGGGGGGGRGKAPAAEIRGEAARDDVFFADDTFPLLPDFPCLSSPSSSTFSSSSSSNSSSAFTTAAGGGCGGEPSEPASAADGFGELADIDQLLDLASLSVPWEAEQPLFPDDVGMMIEDAMSGQPHQADDCTGDGDTKAVMEAAGGGDDAGDACMEGSDAPDDLPAFFMEWLTSNREYISADDLRSIRLRRSTIEAAAARLGGGRQGTMQLLKLILTWVQNHHLQKKRPRTAIDDGAASSDPQLPSPGANPGYEFPSGGQEMGSAAATSWMPYQAFTPPAAYGGDAMYPGAAGPFPFQQSCSKSSVVVSSQPFSPPTAAAAGDMHASGGGNMAWPQQFAPFPVSSTSSYTMPSVVPPPFTAGFPGQYSGGHAMCSPRLAGVEPSSTKEARKKRMARQRRLSCLQQQRSQQLNLSQIHISGHPQEPSPRAAHSAPVTPSSAGCRSWGIWPPAAQIIQNPLSNKPNPPPATSKQPKPSPEKPKPKPQAAATAGAESLQRSTASEKRQAKTDKNLRFLLQKVLKQSDVGSLGRIVLPKEAEVHLPELKTRDGVSIPMEDIGTSQVWNMRYRFWPNNKSRMYLLENTGDFVRSNELQEGDFIVIYSDIKSGKYLIRGVKVRRAAQEQGNSSGAVGKHKHGSPEKPGVSSNTKAAGAEDGTGGDDSAEAAAAAAAGKADGGGCKGKSPHGVRRSRQEAAAAASMSQMAVSI

VP1

Regulatory protein viviparous-1

691 amino acids

Transcriptional activator specifically required for expression of the maturation program in the seed development. Probably potentiates the response to the seed-specific hormone abscisic acid (ABA). May bind to DNA indirectly.

73.329 kDa

MEASSGSSPPHSQENPPEHGGDMGGAPAEEIGGEAADDFMFAEDTFPSLPDFPCLSSPSSSTFSSNSSSNSSSAYTNTAGRAGGEPSEPASAGEGFDALDDIDQLLDFASLSMPWDSEPFPGVSMMLENAMSAPPQPVGDGMSEEKAVPEGTTGGEEACMDASEGEELPRFFMEWLTSNRENISAEDLRGIRLRRSTIEAAAARLGGGRQGTMQLLKLILTWVQNHHLQRKRPRDVMEEEAGLHVQLPSPVANPPGYEFPAGGQDMAAGGGTSWMPHQQAFTPPAAYGGDAVYPSAAGQQYSFHQGPSTSSVVVNSQPFSPPPVGDMHGANMAWPQQYVPFPPPGASTGSYPMPQPFSPGFGGQYAGAGAGHLSVAPQRMAGVEASATKEARKKRMARQRRLSCLQQQRSQQLSLGQIQTSVHLQEPSPRSTHSGPVTPSAGGWGFWSPSSQQQVQNPLSKSNSSRAPPSSLEAAAAAPQTKPAPAGARQDDIHHRLAAASDKRQGAKADKNLRFLLQKVLKQSDVGSLGRIVLPKKEAEVHLPELKTRDGISIPMEDIGTSRVWNMRYRFWPNNKSRMYLLENTGEFVRSNELQEGDFIVIYSDVKSGKYLIRGVKVRPPPAQEQGSGSSGGGKHRPLCPAGPERAAAAGAPEDAVVDGVSGACKGRSPEGVRRVRQQGAGAMSQMAVSI

VP1

Minor capsid protein VP1

671 amino acids

Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1 (Probable). The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid (PubMed:28331084). The capsid encapsulates the genomic ssDNA (Probable). Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).

Belongs to the parvoviridae capsid protein family.

75.085 kDa

MPPIKRQPRGWVLPGYRYLGPFNPLDNGEPVNNADRAAQLHDHAYSELIKSGKNPYLYFNKADEKFIDDLKDDWSIGGIIGSSFFKIKRAVAPALGNKERAQKRHFYFANSNKGAKKTKKSEPKPGTSKMSDTDIQDQQPDTVDAPQNTSGGGTGSIGGGKGSGVGISTGGWVGGSHFSDKYVVTKNTRQFITTIQNGHLYKTEAIETTNQSGKSQRCVTTPWTYFNFNQYSCHFSPQDWQRLTNEYKRFRPKAMQVKIYNLQIKQILSNGADTTYNNDLTAGVHIFCDGEHAYPNASHPWDEDVMPDLPYKTWKLFQYGYIPIENELADLDGNAAGGNATEKALLYQMPFFLLENSDHQVLRTGESTEFTFNFDCEWVNNERAYIPPGLMFNPKVPTRRVQYIRQNGSTAASTGRIQPYSKPTSWMTGPGLLSAQRVGPQSSDTAPFMVCTNPEGTHINTGAAGFGSGFDPPNGCLAPTNLEYKLQWYQTPEGTGNNGNIIANPSLSMLRDQLLYKGNQTTYNLVGDIWMFPNQVWDRFPITRENPIWCKKPRADKHTIMDPFDGSIAMDHPPGTIFIKMAKIPVPTASNADSYLNIYCTGQVSCEIVWEVERYATKNWRPERRHTALGMSLGGESNYTPTYHVDPTGAYIQPTSYDQCMPVKTNINKVL

VP1

Minor capsid protein VP1

670 amino acids

Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid (PubMed:28331084). The capsid encapsulates the genomic ssDNA (Probable). Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).

Belongs to the parvoviridae capsid protein family.

75.402 kDa

MPPIKRQPGGWVLPGYKYLGPFNPLENGEPVNKADRAAQAHDKSYSELIKSGKNPYLYFNKADEKFIDDLKDDWSLGGIIGSSFFKLKRAVAPALGNKERAQKRHFYFANSNKGAKKTKNNEPKPGTSKMSENEIQDQQPSDSMDGQRGGGGGATGSVGGGKGSGVGISTGGWVGGSYFTDSYVITKNTRQFLVKIQNNHQYKTELISPSTSQGKSQRCVSTPWSYFNFNQYSSHFSPQDWQRLTNEYKRFRPKGMHVKIYNLQIKQILSNGADTTYNNDLTAGVHIFCDGEHAYPNATHPWDEDVMPELPYQTWYLFQYGYIPVIHELAEMEDSNAVEKAICLQIPFFMLENSDHEVLRTGESTEFTFNFDCEWINNERAYIPPGLMFNPLVPTRRAQYIRRNNNPQTAESTSRIAPYAKPTSWMTGPGLLSAQRVGPATSDTGAWMVAVKPENASIDTGMSGIGSGFDPPQGSLAPTNLEYKIQWYQTPQGTNNNGNIISNQPLSMLRDQALFRGNQTTYNLCSDVWMFPNQIWDRYPITRENPIWCKKPRSDKHTTIDPFDGSLAMDHPPGTIFIKMAKIPVPSNNNADSYLNIYCTGQVSCEIVWEVERYATKNWRPERRHTTFGLGIGGADNLNPTYHVDKNGTYIQPTTWDMCFPVKTNINKVL

VP1

Minor capsid protein VP1

668 amino acids

Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid. The capsid encapsulates the genomic ssDNA (By similarity). Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).

Belongs to the parvoviridae capsid protein family.

74.85 kDa

MPPIKRQPGGWVLPGYKYLGPFNPLDNGEPVNKADRAAQSHDKSYSELIKSGKNPYLYFNKADEKFIDDLKNDWSLGGIIGSSFFKLKRAVAPALGNKERAQKRHFYFANSNKGAKKSKNNEPKPSTSKMSENEIQDQQPSEPNDGQRGGGGGATGSVGGGKGSGVGISTGGWVGGSYFTDSYVITKNTRQFLVKIQNNHQYKTESIIPSNGGGKSQRCVSTPWSYFNFNQYSSHFSPQDWQRLTNEYKRFRPKGMHVKIYNLQIKQILSNGADVTYNNDLTAGVHIFCDGEHAYPNATHPWDEDVMPELPYQTWYLFQYGYIPTIHELAEMEDSNAVEKAIALQIPFFMLENSDHEVLRTGESAEFNFNFDCEWINNERAFIPPGLMFNPLVPTRRAQYIRRNGNTQASTSRVQPYAKPTSWMTGPGLLSAQRVGPAASDTAAWMVGVDPEGANINSGRAGVSSGFDPPAGSLRPTDLEYKVQWYQTPAGTNNDGNIISNPPLSMLRDQTLYRGNQTTYNLCSDVWMFPNQIWDRYPVTRENPIWCKQPRSDKHTTIDPFDGSIAMDHPPGTIFIKMAKIPVPSNNNADSYLNIYCTGQVSCEIVWEVERYATKNWRPERRHTALGLGIGGADEINPTYHVDKNGAYIQPTTWDMCFPVKTNINKVL

VP1

Minor capsid protein VP1

667 amino acids

Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid. The capsid encapsulates the genomic ssDNA (By similarity). Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).

Belongs to the parvoviridae capsid protein family.

74.937 kDa

MPPIKRQPGGWVLPGYKYLGPFNPLENGEPVNKADRAAQAHDKSYSEIIKSGKNPYLYFNKADEKFIDDLKNDWSLGGIIGSSFFKLKRAVAPALGNKERAQKRHFYFANSNKGAKKPKNNEPKPGTSKMSENEIQDQQPSGSMEERGGGGGAVGSVGGGKGSSVGISTGGWVGGSYFTDSYVITKNTRQFLVKIQNDHKYRTENIIPSNAGGKSQRCVSTPWSYFNFNQYSSHFSPQDWQHLTNEYKRFKPRKMHVKIYNLQIKQILSNGADTTYNNDLTAGVHIFCDGEHAYPNATHPWDEDVMPELPYETWYLFQYGYIPVIHELAEMEDANAVEKAIALQIPFFMLENSDHEVLRTGESTEFTFDFDCEWINNERAYIPPGLMFNPKVPTRRAQYIRQHGNTASSNTRIQPYAKPTSWMTGPGLLSAQRVGPAGSDTASWMVVVNPDGAAVNSGMAGVGSGFDPPSGSLRPTDLEYKIQWYQTPAGTNSDGNIISNPPLSMLRDQALYRGNQTTYNLCSDVWMFPNQIWDRYPITRENPIWCKKPRSDKNTIIDPFDGTLAMDHPPGTIFIKMAKIPVPSNNNADSYLNIYCTGQVSCEIVWEVERYATKNWRPERRHTALGLGIGGEENVNPTYHVDKNGKYIQPTTWDMCYPIKTNINKVL

VP1

RNA-directed RNA polymerase

525 amino acids

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).

57.979 kDa

single

KSTWLTKTRNIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSGNAATFINNHLLSTLVLDQWNLMRQPRPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVPLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNAGAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTVTSESLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAKAEAEKLHKSKPDDPDADWFERSETLSDLLEKADIASKVAHSALVETSDALEAVQSTSVYTPKYPEVKNPQTASNPVVGLHLPAKRATGVQAALLGAGTSR

VP1

Capsid protein

449 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the gyrovirus capsid protein family.

51.883 kDa

MARRARRPRGRFYAFRRGRWHHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSKSQAAENWPNCWLPLDNNMPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGGQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITTTTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMSAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDAWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWETQP

VP1

Capsid protein

449 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the gyrovirus capsid protein family.

51.69 kDa

MERRARRPRGRFYAFRRGRWNHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKLGGPIAGELIADGSKSEAAENWPNCCVPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGGQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITSTTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMGAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDSWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGTQP

VP1

Capsid protein

449 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the gyrovirus capsid protein family.

51.872 kDa

MARRARRPRGRFYAFRRGRWHHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSKSQAAENWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGEQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITSTTAQGTQVRCMYSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMGAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDSWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGTQP

VP1

Capsid protein

449 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the gyrovirus capsid protein family.

51.723 kDa

MARRARRPRGRFYSFRRGRWHHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSKSQAADNWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWQKGGQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITATTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMSAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDAWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGTQP

VP1

Capsid protein

449 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the gyrovirus capsid protein family.

51.938 kDa

MARRARRPRGRFYAFRRGRWHHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSKSQAAENWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGEQPMTGGIAYATGKMRLDEQQYPAMPPDPPIITTTTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMRAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDSWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGSQP

VP1

Capsid protein

449 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (25 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to host receptors. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the gyrovirus capsid protein family.

51.779 kDa

MARRARRPRGRFYAFRRGRWHNLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGIIFLTEGLILPKNSTAGGYADHLYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSQSQAAQNWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGEQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITATTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMSAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDAWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGSQP

VP1

Major capsid protein VP1

357 amino acids

Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.

Belongs to the polyomaviruses coat protein VP1 family.

39.811 kDa

MPLKKRSASAPRKTPQEVPRLLISGGVEVLGLKTGPDSITEVEAFLNPRMGLENTDNHYGYSENVTVAKKKDDDKPLKNQLPCYSVAKIELPMLNEDLTNDTILMWECISVKTEVVGINTLVNTHSYGKRDGESPSMPIVGLNYHFFAVGGEPIEMQYIVQNFQCDYPVGVVAMKPSPLSTQVLDPKQKSKLTGDGIFPIECWAPDPSKNENARYFATYTGGLNTPPVLNITNTVTTILLNENGVGPLCKGDQLHIAAADICGFHIEEDNKYKYRGLPRYFKLVLRKRVVKNPYPVSTLLNTLFTQMSPNVQGQDMTKQVEEVKIYEGTEKLPGDPDMIRFRNQFGQEETVIPVITN

VP1

Structural protein VP1

144 amino acids

Belongs to the fuselloviridae capsid protein VP1/VP3 family.

16.076 kDa

MRLLRSLARKIASLKEAKVALKVASDPRKYFNEEQMTEAYRIFWQTWDGDIIRSARRFVEVAKANPKLTKGEATNIGVLLGLFIFILIGIVLLPVIVSQVNNLTSGTSPQVTGTNATLLNLVPLFYILVLIIVPAVVAYKIYKD

VP1

Eumenine mastoparan-OD

79 amino acids

Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. Also exhibits strong antimicrobial activity against the fungi C.albicans and B.cinerea, and weaker activity against the Gram-negative bacterium E.coli and Gram-positive bacterium S.aureus.

Belongs to the MCD family. Mastoparan subfamily.

8.029 kDa

MKQTIVIVLLAAVAMMACLQMVAAEPLPEAAPAPSPLAEAEALASPIAEALANPEALASPEAGRILSFIKGLAEHLGKK