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VIT_05s0051g00580

Gene
VIT_05s0051g00580
Protein
Inosine triphosphate pyrophosphatase
Organism
Vitis vinifera
Length
206 amino acids
Function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
22.547 kDa
Sequence
MAAAGASASGLILSRPVTFVTGNAKKLEEVRYILGQSIPFNSLKLDLPELQGEPEDISKEKARLAAIQVNGPVLVEDTCLCFNALKGLPGPYIKWFLQKIGHEGLNNLLMAYEDKSAYALCAFSFALGPDAEPVTFLGKTPGKIVPPRGPNDFGWDPIFQPDGYEQTYAEMPKEEKNKISHRYKALALVKSHFAKAGYVFQTDSPI