VIPAS39

Spermatogenesis-defective protein 39 homolog

493 amino acids

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity).

Belongs to the SPE39 family.

57.005 kDa

MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDFVDDDDDDDLERVSWSGEPVGSISWSIRETAGNSGSTHEGREQLKSRNSFSSYAQLPKPTSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDTVRRLRKGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPDKRKEFLKTCVGLPFSAEDSAHIQDHYTLLERQIIIEANDRHLESAGQTEIFRKHPRKASILNMPLVTTLFYSCFYHYTEAEGTFSSPVNLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNNAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTYRDLKDRQQLLAYRSKVDKGSAEEEKIDALLSSSQIRWKN

Vipas39

Spermatogenesis-defective protein 39 homolog

491 amino acids

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.

Belongs to the SPE39 family.

56.625 kDa

MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDIVDDDDDDDLERVSWTGEPVGSISWSIKETAGSSGSTPEGREQLKGRNSFYTQLPKPPSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSLSDTVQRLRRGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRAEELALSHYREHLNIQDPEKRKEFLKTCIGLPFSAEDAAHVQDHYTLLERQIIIEANDRHLESSGQTDIFRKHPRKASILNMPLVTTLFYACFYHYTESEGTFSSPINLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNSAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTCRDLKDRQQLLAYRSKVDKGSAEEEKIDAILSSSQIRWKN

vipas39

Spermatogenesis-defective protein 39 homolog

483 amino acids

Proposed to be involved in endosomal maturation implicating in part vps33b. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical rab11a-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of vps33b. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.

Belongs to the SPE39 family.

56.073 kDa

MTRAKPEDDEYWNSSKFKAFTFDDEDDEFSRLKESKRAVNSILVDDDDDEDDVEKVSWSGEPVGSISWSVRETASSIRSGSEQNFPKIDTAPSLSKQGSGYSLSSLFKAKSKPTAFQSFSESFSETSARTYAPELRKPKSDGKDFVSDLSPEETIRRMQKGRAFSMEKFRSLQDKLLLLDEAVSVYDGNVITAVLIYLKKSLSKEILFRELMPREVALRHYIHYLKEMGEQKLLVELLKALGRTEDMALMQYKEHLNIKDEGRRRDFLKSCLSLPFSQDDSTHVQDHYTLLERQIIIEASDKKADTDIFKKFPRKASILNMPIITTLYYSCFYHYGEPEGTFSSPSNIRKTFRISEKQYITTALGARAKLKSWFDVDSLFNTKNWLGYTKKRSPIAFHRVVDILQKNSAPVQVLQEYVNLIDDPELKLSVALKYKCHDIIINTYRDLKDRQQLIVYREKLERDSPEYRKIQELLNNGQIRWKN

VIPAS39

Spermatogenesis-defective protein 39 homolog

481 amino acids

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity).

Belongs to the VIPAS39 family.

55.615 kDa

MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDFVDDDDEDDLERVSWTGEPVGSISWSIKETAGNSGSSHEREQLKNRNSFSTYAQLPKPASTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDTVRRLRKGKDKIQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPEKRKEFLKTCIGLPFSAEDSAHIQDHYTLLERQIIIEANDRHLELAGQTEVFRKHPRKASILNMPLVTTLFYSCFYHYTEAEGTFSSPVNLKKTFKIPDKQYVLTALAARAKLRAWHDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNSAPVQVLQEYVNLVEDVDTKLNLATKFKCHDVVIDTCRDLKDRQQLLAYRSKVDKGSAEEEKIDALLNSSQIRWKN

Vipas39

Spermatogenesis-defective protein 39 homolog

460 amino acids

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity).

Belongs to the SPE39 family.

53.305 kDa

MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRDFVDDDDDDDLERVSWTGEPVGSISWSIKETAGSSGSTSEGREQMKGRNSFYTQLPKPPSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKTYSPELGRPKGEYRDYSNDWSLSDTVRRLRQGKVLIFLKRTLSKEILFRELEVRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPEKRKEFLKTCIGLPFSAEDSAHVQDQYTLLERQIIIEANDRHLESSGQTEIFRKHPRKASILNMPLVTTLFYACFYHYTESEGTFSSPVNLKKTFKIPDRQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRAPIGFHRVVEILHKNSAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTCRDLKDRQQLLAYRSKVDKGSAEEEKIDVILSSSQIRWKN