Function
Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG (PubMed:25837739, PubMed:30365951). Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs); is also able to hydrolyze c-di-GMP but not c-di-AMP (PubMed:25837739).
Sequence
MSVAQNTFPLSELMISLTTALDMTEGQPPEHCIRCCWIGMHIGMQLELSEPELHDLFFTLLLKDAGCSSNAARICELYATDDLTFKRRYKTVGTSLSSVINFIVKNTGSEQSWTERILTTIDILKNGNDYAQELIQTRCTRGADVARELRFSEAVAQGIHSLDEHWNGQGRPEQRKGEAIPLFSRIALLAQVFDVFQMEHSIEEALQEIMARSGVWFDPKLVEVVEQLVENPRFLSGLKATDISQRVMNLPPAQAHLPLDDAYLECIVTAFGKIVDAKSPYTAGHSERVAVYTDLIARQLAISDADRIWLRRAALLHDIGKLGVSNAILDKPGKLDEAEWRAVQAHAAYTEQILYKLSPFKTLARMAGAHHEKLDGTGYPRGVNGDEISLMTRIITTADIFDALSAERPYRAAMPIDKALAIMEENLHTAIDPECFAALKKALNLLPDEYTQLPHSSDKT