VAPB

V-type proton ATPase subunit B

494 amino acids

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Belongs to the ATPase alpha/beta chains family.

55.789 kDa

MSKEVVNTKAEASRVNALAAVRNYKVCPRLEYKTISGVQGPLVIIEDVKFPKYSEIVTIHLSDNTTRQGQILEVCGKKAVIQVFEGTSGIDNKNSYVEVSGDILKMPMSDEMLGRVFNGSGKPIDKGPNILADDYLDINGNPINPQCRVYPKEMIQTGISTIDVMNSIVRGQKIPLFSAAGLPHNEIGAQICRQASLVQGKDVLDHSDDNFAVVFGAMGVNMETARYFRQDFEENGKMERVCLFLNLANDPTIERILTPRIALTTAEYLAFEKEMHVFVILTDMSSYADALREVSSAREEVPGRRGYPGYMYSDLSTIYERAGRVEGRNGSITQFPILTMPNDDITHPIPDLTGYITEGQIFVDRNLYNRQIYPPINVLPSLSRLMKSGIGHNMTRIDHPYVSDQLYSNYAIAQDVKAMKAVIGEEALSNDDILYLEFLDKFEKRFITQNTYECRDIYQSLDIAWELLRIFPEDMLKKIKTDILSKYYPRHHAN

VAPB

Vesicle-associated membrane protein-associated protein B

243 amino acids

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

27.158 kDa

MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIIPTTASKTETPTVSKALSSSLDDTEVKKVMEECKRLQSEVQRLREENKQFKEEDGLRMRKTAQSNSPAPASAMAGKEEGLSTRLLALVVLFFIVGVIIGKIAL

VAPB

Vesicle-associated membrane protein-associated protein B/C

243 amino acids

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

27.228 kDa

MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL

Vapb

Vesicle-associated membrane protein-associated protein B

243 amino acids

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

26.946 kDa

MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTVPRRYCVRPNSGVIDAGASLNVSVMLQPFDYDPNEKSKHKFMVQSMFAPPDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENAKPHDVEINKIIPTSASKTEAPAAAKSLTSPLDDTEVKKVMEECRRLQGEVQRLREESRQLKEEDGLRVRKAMPSNSPVAALAATGKEEGLSARLLALVVLFFIVGVIIGKIAL

VAPB

Vesicle-associated membrane protein-associated protein B

243 amino acids

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

27.053 kDa

MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPADTSDMEAAWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPVVSKALSSALDDTEVKKVMEECKRLQSEVQRLREENKQLKEEDGLRMRKPVLSNSPAPAPATPGKEEGLSTRLLALVVLFFIVGVIIGKIAL

Vapb

Vesicle-associated membrane protein-associated protein B

243 amino acids

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

26.916 kDa

MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGASLNVSVMLQPFDYDPNEKSKHKFMVQSMFAPPDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENAKPHDVEINKIMPTSASKTEAPVAAKPLTSPLDDAEVKKVMEECRRLQGEVQRLREESRQLKEEDGLRARKALPSNSPMAALAASGKEEGLSARLLALVVLFFIVGVIIGKIAL

vapB

Antitoxin VapB

95 amino acids

Antitoxin component of a type II toxin-antitoxin (TA) system. Partially neutralizes the RNase activity of cognate toxin VapC.

11.046 kDa

MAQIVKATEAVRSFSDIINRVYYKGESFDIQKGNNIVAQITPVENKSSVKVKNLDELFKNGPHLDPEDAEQFMKDVDDVRRSTRINIEELYRKWD

vapB

Antitoxin VapB

84 amino acids

Antitoxin component of a type II toxin-antitoxin (TA) system. Upon overexpression neutralizes the effect of overexpressed cognate toxin VapC. Overexpression alone prevents cells from entering a nonculturable dormant state, probably as it binds endogenous VapC (PubMed:24417293). The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. Translation of vapC mRNA requires VapB.

9.28 kDa

MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDRGLPS

vapB

Virulence-associated protein B

76 amino acids

Belongs to the VapB family.

8.899 kDa

MKVAKVFTTGRSQAVRIPKAFQFDTKEVIIQRFGNGILLIPKNSDWQGFLEALNEFEPDFKIEREPQIEQVREDFL

vapB

Antitoxin VapB

75 amino acids

Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.

Belongs to the VapB family.

8.515 kDa

MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

vapB

Antitoxin VapB

75 amino acids

Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC. The VapB/VapC complex probably regulates transcription of its own promoter.

Belongs to the VapB family.

8.566 kDa

METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHSVSTDFMDNREQPGMQERESF