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VAPA

Gene
vapA
Protein
V-type proton ATPase catalytic subunit A
Organism
Plasmodium falciparum (isolate 3D7)
Length
611 amino acids
Function
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Similarity
Belongs to the ATPase alpha/beta chains family.
Mass
68.576 kDa
Sequence
MTKVAVEKEEPGVVYKVAGSLVIAENMSGTRMYELAKVGWNKLVGEIIRLEGNYAYIQVYEDTSGLSVGDPVIKTGNALSVELGPGILDNIYDGIQRPLERIANVCGDVYIYKGIDMTSLDHDKQWQFYADKKLKLNDIVTGGDIFGFVDENKLFKEHKIMAPPNAKGRLTYIAPDGSYTLKDKIFELEYQGKKYTYGLSHLWPVRDPRPVLEKVTGDTLLLTGQRVLDSLFPTVQGGTCAIPGAFGCGKTCVSQALSKYSNSEVIIYVGCGERGNEMAEILSDFPELTTKVDNEDVGIMQRTCLVANTSNMPVAAREASIYTGITLCEYFRDMGYNATMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGKVKCIGSPSRIGSITIVGAVSPPGGDFSDPVTTATMSIVQAFWGLDKKLAQRKHFPSVNWSTSFSKYVRQLEQYFDNFDQDFLSLRQKISDILQQESDLNDIVQLVGKDSLSEDQKVVMEVAKIIREDFLQQNAFSDYDYMCPLQKTVGMMRIICHFYAQCLRTLQEYDSRERKIGWGSIYNTLRPTINKITHMKFENPKNSDEYFKKYFKALEEEITVGLRNLMEK

Gene
vapA
Protein
V-type proton ATPase catalytic subunit A
Organism
Plasmodium falciparum
Length
611 amino acids
Function
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Similarity
Belongs to the ATPase alpha/beta chains family.
Mass
68.576 kDa
Sequence
MTKVAVEKEEPGVVYKVAGSLVIAENMSGTRMYELAKVGWNKLVGEIIRLEGNYAYIQVYEDTSGLSVGDPVIKTGNALSVELGPGILDNIYDGIQRPLERIANVCGDVYIYKGIDMTSLDHDKQWQFYADKKLKLNDIVTGGDIFGFVDENKLFKEHKIMAPPNAKGRLTYIAPDGSYTLKDKIFELEYQGKKYTYGLSHLWPVRDPRPVLEKVTGDTLLLTGQRVLDSLFPTVQGGTCAIPGAFGCGKTCVSQALSKYSNSEVIIYVGCGERGNEMAEILSDFPELTTKVDNEDVGIMQRTCLVANTSNMPVAAREASIYTGITLCEYFRDMGYNATMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGKVKCIGSPSRIGSITIVGAVSPPGGDFSDPVTTATMSIVQAFWGLDKKLAQRKHFPSVNWSTSFSKYVRQLEQYFDNFDQDFLSLRQKISDILQQESDLNDIVQLVGKDSLSEDQKVVMEVAKIIREDFLQQNAFSDYDYMCPLQKTVGMMRIICHFYAQCLRTLQEYDSRERKIGWGSIYNTLRPTINKITHMKFENPKNSDEYFKKYFKALEEEITVGLRNLMEK

Gene
vapA
Protein
S-layer protein
Organism
Aeromonas salmonicida
Length
502 amino acids
Function
S-layer protein. The S-layer is a paracrystalline mono-layered assembly of proteins which coats the surface of bacteria. This S-layer, also called A-layer, confers virulence to the bacterium infecting salmonid and non-salmonid fish. It binds specifically to laminin and fibronectin.
Mass
52.869 kDa
Sequence
MFKKTLIAAAIVVGSAAPAFADVVISPNDNTFVTTSLASVTKQPVLDFSTAQQNLTLNFSEVGDLKNNGFIVLEIQGEGQFNDAEIRQWLSNGFWRRPFTGLLVNPNDHGNFANSGEVNDVRKFFKIISDGTQLTIVHTIDSNGKRLRLALASDVEETINFADAEVELKLNLANQAFKLTSGSQGTVALTAGALWNASYTADPVATKPLFKLGKLFQLSLTNAGKATALVSEGFLKLNIGDANISATDFAITNVTTNQTIQRDKVNLTLTGDVSAFKKDANGNLVNKAGASIGWKAAADGQSATAVLGAGNMAGGVQNALAAFGTLYVAADNTVPVPAVNFNVKAEIQGDSQATYNYFKDELADLFILTRDGMKFDTITTGTTSANLIHIRDVSNILPTEGGKIFVTITEYADHAANGRGEGTVLVTRKALSVTLPSGGAVTLKPADVAADVGASITAGRQARLVFEVETNQGEVAVKKSNAEGVDIQNGTRGTAPLVDFTL

Gene
VAPA
Protein
Vesicle-associated membrane protein-associated protein A
Organism
Bos taurus
Length
249 amino acids
Function
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Similarity
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Mass
27.856 kDa
Sequence
MASASGTMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGLTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNAAKQDGPVPKPHSVSLSDTETRKLVEECKRLQGEMMKLSEENRLLRDEGLRLRKVAHSEKPGSTSAVSFRENVTSPLPSLLVVIAAIFIGFFLGKFIL

Gene
VAPA
Protein
Vesicle-associated membrane protein-associated protein A
Organism
Homo sapiens
Length
249 amino acids
Function
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).
Similarity
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Mass
27.893 kDa
Sequence
MASASGAMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL

Gene
Vapa
Protein
Vesicle-associated membrane protein-associated protein A
Organism
Mus musculus
Length
249 amino acids
Function
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Similarity
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Mass
27.855 kDa
Sequence
MASASGAMAKHEQILVLDPPSDLKFKGPFTDVVTTNLKLQNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSIVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPLPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSAVSFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL

Gene
VAPA
Protein
Vesicle-associated membrane protein-associated protein A
Organism
Pongo abelii
Length
249 amino acids
Function
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Similarity
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Mass
27.893 kDa
Sequence
MASASGAMAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL

Gene
Vapa
Protein
Vesicle-associated membrane protein-associated protein A
Organism
Rattus norvegicus
Length
249 amino acids
Function
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking (PubMed:19289470).
Similarity
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Mass
27.841 kDa
Sequence
MASASGAMAKHEQILVLDPPSDLKFKGPFTDVVTTNLKLQNPSDRKVCFKVKTTAPRRYCVRPNSGVIDPGSIVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPLPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSAVSFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL

Gene
vapA
Protein
Virulence-associated protein A
Organism
Dichelobacter nodosus
Length
102 amino acids
Similarity
Belongs to the VapA/VapI family.
Mass
11.266 kDa
Sequence
MAKMKNPPHPGLMLKVMYLEPLGLNITETAEKLDMPRSALSEIVNAKRAISPEVAVKLEKAFPKHSASFWLRAQAGYALSRVNPHCADKVKPIKTSPLMESV