Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1311 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

141.002 kDa

MPVSLAVCETTTTTTANVVNAALRESLLGGSRSGAAVAGSGSASSLISGAGGAGASAANDDDSSSTATANTNLQNQIVASAKRVLLAKIEYEEVENYNDSVLDNLKTKYVVIKSPTPAAAAAATNNGNSNSAGSKILGANGHDNRQKQQNANGGCSTPTTTTTQTSSSSTSSSSIEHNNNPNELPKPKRVLYQRENIRIGWKQSERKWQIGAGMINVGNTCYLNSTLQALFHIPALANWLNSEQSHLENCNIGGESGGGGGGGGGNNGGFCIICAMAKTLQSTQSNASAIRPYHIYSKLKQICKHMVIGRQEDAHEFLRFLVEAMEKAYLMRYRNYKELDQLVKETTPLNQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKSDTLDEAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLQRAPITLCIQLKRFSMIGNKLTKQISFKPRIDLSRFAARSPTAQGQLPLTYRLVSLVTHLGVSQHCGHYTAIGLTESGSYYNFDDSYVRPIAMQSVCSTNSYIMFYELDLNQPLATPANKLNGLRQLSNGHHHHQQQQQQHQQQQQQQPTVVATIASSPMATTRFIGPQLPPGGLNGYAMTTTTTATNNTTNGHSQKTAIQFKPQQNGILTVGSGKFQESGQQKSPLVGTNHKNEAPAVAPNANANANGKSSSNPNTNTTINTNTNNGNSNNNNTNATTANNSNKLNQQQQQYLPMSSSDEEDSDEEKMKRPTTTTPQLPSMPKMDGGGDEKPKTLTLTPTTTPTASTPTVSNPLKRLVPYESASEEEESSSGTPSSSTPTTTTTAAAAAASSPMQATAAATLPPPPTPTNARKRSLPDHHHHHPHHHVMVNGHGKSPKPASMPPATNFNSSSSKQKTDAIDEIFKSLNNFNKKRINNKNQKHNEGDEEEDDEETLEKETNNSSRLVSSSTNTSPTTNGWKQSQIVSSSSSNSKNVSTSAAAAAATTSSSTSTSAPPSPKTPPSPAVINSKTGLWKVTRNLDDDDDEEEEDEDDEEHIAPTPPPVVAKTHKNPFSSQQKPTPSPSTEAAPKRQKLFNGTSSSTPHVGNGYQSEPSTPNGGGSGSGSNGCLNELLKQSHRGYGSSSVLSWNGKQTELDKEPFELVCAKRIAVDHGDHDDGGGGDDGGGVGVVTTTTTTTTTTKNTTKTLTADAQEQRQRDLDDDEENEMDRGRQRKVKTATANGKSSGNSNNTTPGYNPFQEYESQKRWHNKSSNGPPRFYTQHASSSYRSNFHQRNKFKCNRGGNGGGGSGGISKFDHRHGLQRHLAAGGGFPRRPNANQQQQQQQS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1240 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

134.998 kDa

MPVSLAVCETTANVVNAALRESLGSCVARAALSADEAKTSNGGGDGSSTSGSSTDNLQSQIVANAKRVLLAKIDYEEVDNYHESVLAKLKSKYIVIKPDSNGGAASNGNGNYNGSNKTNGKFGAGNGHDNNGNGNGIVNGGTSALNGGNNRKQIVVVDHQSSNQHGSPSNPNELPKPKRVLYQREHIRIGWKQSERKWQVGTGMLNVGNTCYLNSSLQALFHIPSLANWLVSESAHLENCNISESCGSNGCIICAMAKTLQSTQSNQSAVRPFLIYSKLRQICKHMVVGRQEDAHEFLRFLIEAMEKAYLMRFRNYKELDQLVKETTPLNQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKSDTLEDAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMMGNKLTKQISFKPRIDLSRFAARSPTAAAQPLSYRLVSMVTHLGVSQHCGHYTAIGLTETGSYYNFDDSCVRPIAMQSVCNTNAYIMFYELDVNGNGHVVAPKMNGMRLTTNGGQQHSSPVVATAPAAVVSATATSTSASVSAAAVTSPRFIGPQLPNGYGNSNGHALGGGAAKTAIQFKTTPQKHQQQQQAQTQYQLNGHINGAAKFQTGAANANANKSSCNTLNNSKQHQPQQQQQQPQHILPISSDEEEDSDDDNDNDNVKTNKAPQLPSMPKMFEESSESVALTAKLKPKTALKSLVPYESASEEEEQQQQQQQQTLQQQAATNSRKRRSGADSSDTDDDDDEEQQQQQQQQPSLILRNGHAKTNGNLLNSSSSKTKSASNASSANVNSSKQKTDAIDEIFKSLNNYKNKHRNDHNHVDDDDDDDEDEDEDEDEAQAQAEKKTVTKSSSSSSSTSLTNGWQQSQNGKATASPKTPPSPAVIKTKTGIWQVTRNDEDDDENVDGVADADDDDDNDEVAEPAVVTAKNHKNPFAAGKATATTDANPSAKRQKLLNGSSKSQQTTPRIGNGYQGESLPNGNAVVSELLKQNHRGYGSSVLSWNGKASELDKETFDLVCAKRIAGYGAAAADEHCCDVNSGHSSNYGTNYKSLNNDMSSSSSSSSSTNSSSNSSSRSNGNSSNCPPCDLLAEAREQRKRDDDDEEENEMDRGRQRKIKSASVKCGSGATAAPPGYNPFQEYESQKRWHSNKSGSYSRFYHHPNYRSNFQQRNKFKHNRFAGGGGGAKFQQQRALQRHLASGGGFTRRQHHQSSGQQQQQS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1214 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

132 kDa

MPVSLAVCETANVVNAALRESLGSGIGGGGGCVAAAASRSSAGSGSGSVAGVDEAKIGDVSGTDNLQSQIVANAKRVLLAKIEYEEVENYHESVLAKLKSKYIVIKPDNNNGAANCNYKTNGKAVGSNGHDNNTVNGGTVNGNRKQTVDSGQSNQNSSANPNELPKPKRVLYPRENIRIGWKQSERKWQVGAGMLNVGNTCYLNSTLQALFHIPALANWLVSETSHVENCNISESCGSGGCIICAMAKTLQTTQSNQSAVRPFLIYTKLRQICKHMVVGRQEDAHEFLRFLVEAMEKAYLMRFRNFKELDQLVKETTPISQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADTLEEAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMMGNKLTKQISFKPRIDLSRFAARSPTAAAQPLSYRLVSMVTHLGVSQHCGHYTAIGLTEAGSYYNFDDSYVKPIAMQSVCNTNAYIMFYELDVANSSSSSTINNNSSSSSNNSVAPKLNGLRLSNGAHSPAAATVAVAATATSTSASAVSPRFIGPQLPNGYANSNGHALGGAKTTIQFKTTPQKQLQQQQQQQNGLLMGANKFQESSQSKHSLAGTLHKGEAAPNANTNANANKSSCNNNITSQHQQQHILPISSDEDEDEDDSDDDDDDDDDDVKANTAPQLPSMPKMFEDSESVAQTAKLKPKTPLKSLVPYESASEEEQEQQQQQQQQQLLQTPQQLAANPRKRRSGSDSSESEEEAPPPLPSILRNGHAKTNGSVSNTSNSSHSKAKSASNASSANVNSSKQKTDAIDEIFKSLNNYKNKHRIAADDDEDGDGDGDGHGNEQVQTEQGTKKLNSASSASASKSNGWQSQNGKAPSSPKTPPSPAVIKSKTGIWQITRTNDDDDEEDEEEDDVEADADQEDDDDEVVVVEEPQVSVTPKNPKNPFAASKSAEANATIAGAKRQKLLNGSAKSAATTRPGNGYQSESVANGSAVSELLKQNHRGYGTSVLSWNGKPSELDKESFDLVCAKRIAGHGDTDVHSDVNSSSNNSSNINSNSNSNSNGNGKRKNSTLLAEAREQRKRDAEDEEENEMDRGRQRKVKSASVKSNNSTPGYNPFQEFENQKRWHSNKSGTFPRFYHQNNRPNFQQRNKFKFNRFGGGAKFQQQRALQRHLAAGGGFTRRQQQSTGQQQQQQQQQQQS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1185 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

128.969 kDa

MPVSLAVCETANVVNAALRESLGGGGGSGCVAAAAASGRSGSGSSSTAAAAASADEAKIGDPSATDNLQSQIVANAKRVLLAKIEYEEVENYHESVLAKLKSKYIVIKPDNSGAANCSYKTNGASTGKALSSNGHDNTNGVNGSSAATVNGNRKQTVEQSNQNSTTNPNELPKPKRVLYPRENIRIGWKQSDRKWQVGAGMLNVGNTCYLNSTLQALFHIPALANWLVSETAHVENCNISESCGSGGCIICAMAKTLQTTQSNQTAVRPFLIYTKLRQICKHMVVGRQEDAHEFLRFLVEAMEKAYLMRFRNYKELDQLVKETTPLSQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADTLEEAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMMGNKLTKQISFKPRIDLSRFAARSPAASTQPLSYRLVSMVTHLGVSQHCGHYTAIGLTESGSYYNFDDSYVRPIAMQSVCNTNAYIMFYELDVASSSINSSSSCSTSVPKLNGLRLNGQHSPSVATTAVAATATSTSASAVSPRFIGPQLPNGYANNNGHVLGAAKTSIQFKSSPQKQPQQQQHNGLLMGANKFQESAQSKHSLVGSLHKGETAANASANAISNANSNKSSCNNNTLTTNSQHQQQHILPISSDEEDEDEDSDDDVDVKANTAPQLPSMPKMFEDAESVAQTAKLKPKTPLKSLVPYESASEEEQEQQQQQQQLLVSPQLQPANPRKRRSGADSSESEDEPPSIMRNGHAKSNGSGNESSTSTSIKSNNNKQKTDAIDEIFKSLNNYKNKHRATAAGTTTADADEDEQQQQQVTKKPSNSSSSLISKNGWQSQNGKAPASPKTPPSPAVIKSKTGIWQITRTDDDNDDDDEDADEEDDADADAEQEEYDDEVVVVETTPSITTKNLNNPFASKPSSADAMPGAKRQKLLNGSAKSAQTPRVGNGYQSEATANGNAVSELLKQTHRGYGTSVLSWTGKTSDLDKQSFDLVCAKRIAGYGDMDGSVGVSSDSNINNSKNIDSNSNIKSLTAPTLLAEAREQRKRDAEDDEENEMDRGRQRKVKSASVKSNNGIPGYNPFQEFESQKRWNGNKSGSFPRFYQNYRQNFQQRNKFKYNRFGGGGAKFQQQRALQRHLAAGGGFTRRQHQSTGHQQQQQQQQS

USP36

Ubiquitin carboxyl-terminal hydrolase 36

1123 amino acids

Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).

Belongs to the peptidase C19 family.

122.908 kDa

MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPQHFSPRTAQGLPGTSNSNSSRSGSQRQGSWDSRDVVLSTSPKLLATATANGHGLKGNDESAGLDRRGSSSSSPEHSASSDSTKAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADSKTVKLKSPVLSNTTTEPASTMSPPPAKKLALSAKKASTLWRATGNDLRPPPPSPSSDLTHPMKTSHPVVASTWPVHRARAVSPAPQSSSRLQPPFSPHPTLLSSTPKPPGTSEPRSCSSISTALPQVNEDLVSLPHQLPEASEPPQSPSEKRKKTFVGEPQRLGSETRLPQHIREATAAPHGKRKRKKKKRPEDTAASALQEGQTQRQPGSPMYRREGQAQLPAVRRQEDGTQPQVNGQQVGCVTDGHHASSRKRRRKGAEGLGEEGGLHQDPLRHSCSPMGDGDPEAMEESPRKKKKKKRKQETQRAVEEDGHLKCPRSAKPQDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERESDVVQELLKYSSDKAYGRKVLTWDGKMSAVSQDAIEDSRQARTETVVDDWDEEFDRGKEKKIKKFKREKRRNFNAFQKLQTRRNFWSVTHPAKAASLSYRR

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1098 amino acids

Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity).

Belongs to the peptidase C19 family.

119.913 kDa

MPIVDKLKEALKPGRKDSAEDGDLGRLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLLSARAEGASRHRSGDELQARKPGTERVSGSGGDGVPAPQKVLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCHQGGFCMLCLMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVVPEHSKKSPGNGVVPSPLMAKRQDSVMMRKLPAPEEVGVPVSRNGSLPGLKLQNGCAPAKTPAGSPSPRLTPTPTHMPTILDEPGKKVKKSAPLQSLTTSPTTSQGSPGTGESRSQRPGSWASRDTIFSTSPKLLARAITNGHRLKGEGSGVDLEKGDSSSSSPEHSASSDPAKAPQTAESRAAHACDSQGTNCPTAGHPKALLNGVDAKMVKLKSPALSSTTTEPTSLMSPPPAKKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASTGPVSKTRTAAPAPRPSTHPHSASLSSSSAKPLGTSEPQSCRPSAWTPLPQVNGHFTSHLHQLPEASEALHSPSKKRKKTPNGDPQRLGIDTLLPQCLRGAPAAARRKRKKRCSEGEGATAPKQEGQFQDQSWSSGSQKEEGTQPQVNGHQVSHILDSYHVSSRKRRKRKRSEGLSQEATPSQDLIQHSCSPVDHSEPEARTELQKKKKKKRRKRKPEPQQDEESKHPGDQRSPRPSVTPVPALSVNGHLPSDCLGLGQAPLVTWNRDQEPDVVQALLQDSSDKAYGKKVLTWDGEPSAISQDAIKDSRLARTQTVVDDWDEEFDRGKEKKIKKFKREKKRNFNAFQKLQSRRNFWSVTHPAKVASLSYRR

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1091 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

119.512 kDa

MPVSVAVCETTNVVNAALRESLGVGIGSGGASSDDKSAGEDTNSLQNHIVANAKRILMTKIEYEEVPNYQEAVLENLKSKYIVIKPTNPTNGCNLNGNTANTFGNKNNAGKIVGANGHDNNGRKLSDHPNQNHNHANPNGHHANPNELPKPKRVLYPRENIRIGWKQSERKWQVGSGMINAGNTCYLNSTLQALFHIPALANWLVSEQAHMENCNVSESGSFCIICAMAKTLQATQTTQSAVRPFLIYTKLKQICKHMIVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKSDSLEEAFEGYFSREKLEDFGYKCEGCKKKVSATKQFRLERAPITLCIQLKRFSMMGNKLTKQITFKPRIDLSKFAARSPAASVQPLIYRLVSMVTHLGVSQHCGHYTAIGSTEAGSYYNFDDSYVRPIAIQSVCNTNAYIMFYELDPLQTSSPAAARANGLRLTNGHGPVPVAVPATVSSPLPSPAKFIGPQLPPGGINGYSNGHGPKTTIQFKPQHQPSHQQNGVQQSAKSPLLSTHVKVEAAAGAAALAASAAPTANGNKSSSNHSNHKSVNQQHYLPISSEDEDSEDEVKARPTVQLPSMPKMDDCMDSGKPKSPVKTPVKTPLKSLVPYESASEEEEVVPLPNPNARKRSSDSSDSEHEPTTSSVQLNGHSKTNGSLSNGSSKSTDAIDEIFKSLKGYQAKKKSADSEDDDDDEDEPNNQLTNGWHPQKQSQSQSRSGPPSPKTPPSPAVIKSKTGIWKVTRDDGDDDEDDDDDDDEVVEEARAVRTPVKNHRNPFASSKTATDSPTTPGAKRQKLLNGSAIKTQQQPRAGNGYQSEATANGGTVNELLKQSHRGYSSSVLSWNGKPAELEKEPFVLVCAKRIAGHGSLDGSGSGSNTDIIDTEIPAAAVNFPSGSCSFSLLADARDQRQRDLADDEENEMDRGRQRKVKSGSAKISNSTPGYNPFMEFENQKRWHKNGGGGGFPRFYQNQNFRQGFQQRNKFKFNRFGGPGSAKFQQQRALQRHLAAGGGFTRRQPTHSAQQQQQQQS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1085 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

118.856 kDa

MPVSMAVCETANVVNAALRESLGGNSSAAGSSADQAKSGEESNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLESLKSKYIVIKPGNPGAINGFGGKNNTGKVVGANGHDNNGARKQAEHPNNQSHHNNHNNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLENCNVAESGGGCIVCAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADTLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISFKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGVSQHCGHYTAIGSTDTGSYYNFDDSYVRPIAMQSVCNTNAYIMFYELDLSQTASPAANRPNGMRLTNGHSTTPVPATTVSSPSPTRFIGPQLPPGGVNGYSNGNAQKTAIQFKQHHQQSQQNGFQLGTGKFQDTAKPPLVGAHAKGEANPAPTANGNKSSSTSSNNSSSSNHKSINQQQYLPISSEDEDSEDERTSRPSTVQLPSMPKMTDDHTEKPKSPVKIQAKTPIKTPLKSLVPYESASEEEEAPLPNPRKRRSGEDSSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKLKTDAIDEIFKSLKKSADSDDDDDEEESSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDDIDDDDDEEEEATVKIQTPSKTHRNPFSSSKPSTDSPATPGAKRQKLLNGSPVKSHQQPRVGNGYQSEATSNGSTINELLKQSHRGYGSSVLSWNGKPAELEKETFELVCAKRIAGHGSVDGSDIVESSVAVNASSGSDSNDVVVIAVALLVDAREQRQRDLDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGGFPRFYNQNFRQNFQQRNKFKFNRFGGPGGAKFQQQRALQRHLAAGGGFSRRQPSAQQQQQQS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1082 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

118.583 kDa

MPVSMAVCETANVVNAALRESLGGNSSAAGSSIDQAKSGEDSNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFGGKNNTGKVVGANGHDNNGARKQAEHPNNQSHHNNHNNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLENCNVAESGGGCIVCAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISLKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGVSQHCGHYTAIGSTDTGSYYNFDDSYVRPIAMQSVCNTNAYIMFYELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPPGGVNGYSNGNAQKTAIQFKQHHQQSQQNGFQLGTGKFQDTAKPPLVGAHAKGDANPVPTANGNKSSSTSSNSSSNHKSINQQQYLPISSEDEDSEDEMTPRPTTAQLPSMPKMTDDHTEKPKSPVKIQVKTPVKTPLKSLVPYESASEEEEAPQPNPRKRRSEEDSSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSDDDDDEEESSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDDIDDDDDEEDEAPAKIQTPSKTHRNPFSSTKPSTESPATPGAKRQKLLNGSAVKSHQQPRVGNGYQSEATSNGSTINELLKQSHRGYGSSVLSWNGKPAELEKEPFELVCAKRIAGHGSVDGSDIVESSVAVNASSGSDSNDVVVIALLVDAREQRQRDLDDDEENEMDRGRQRKVKSSGSAKANNASNSTPGYNPFQEYEGQKRWNKNGGGGGGFPRFYNQNFRQNFQQRNKFKFNRFGGPGSAKFQQQRALQRHLAAGGGFSRRQPSAQQQQQQS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1059 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

116.372 kDa

MPVSMAVCETANVVNAALRESLGVGNGSRAADEAKKTGGGGGDDSDSEMHNQIAVSAYAKRILMSKIEYEEVPNYHDSVLEQLKNKYIVIKQPSNNNNSSSCNGSNFGNSKVVGANGHDNGNNGHRKLTQSESTQSGPSPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALFHIPALANWLVSEQTHLENCNITESNGGCIICAMAKTLQSTQSCQSAMRPFHIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMEKAYLMRFRNFKELDQLVKETTPLNQIFGGYLRSEVRCLSCSHVSITFQHFQDLLLDIRKSDTLEEAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKTISFKPRIDLSRFAARSPAAAAQPLTYRLVSMVTHLGVSQHCGHYTAIGMTESGSYYNFDDSYVRPIAMQSVCNTNAYIMFYELDLSQTTPLKSNGLRLTNGHSQVAVPATVSSSSPTHTRFIGPQLPPGGINGYSNGHATGSSNAQKTAIQFKQQQQHPQQNGLQVGTGKFQEPPHAKSPLAGAYNKGEAFPATTANGNKSSSSSASNSNHNKSVNQLQHQQHYLPISSEDEDSEDGATATATATATARPTAQLPSMPKMTEDSSDKPKTPLKSSVKTNLVKSLLKTPLKSLVPYESASEEDEPLPNPRKRRSDSDSNDSGDSDPQPGHVNGHTKTNGGSLTNGNGLGKAKTILATSSSSSLASASASAASDDEDADEEEENSKLTNGWQPQKQSQSLTQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDDNEDEDDDDDEDEEEQHQVVSTPSKNPRNPFAKSSTTPGAKRQKLLNGIAVKSQQQPRVGNGYQSEASTNGNVVNELLKQTHRGYGSASVLSWSGKPAELEKELVAEAREQRQHDHDDEEENEMDRGRQRKVKSATAKAYNSSTPGYNPFQEYESQKRWHKSSNGGGSFPRYHNQNFRQNFQQRNKFKYNRFGGPGGAKFQQQRALQRHLASGGVFNRRQPTGQQQQQQSQQSSS

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

1059 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

115.591 kDa

MPVSMAVCETANVVNAALRESLGGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKLKRFSMIGNKLTKQISFKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPITMQNVCNTNAYIMFFELDLSQAASPPANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPPGGANGYTNGNAQKTAIQFKQQNQQNGLQLGTGKFQDTAKPPLVGAYAKGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIDDEMKPGPTTAQLPSMPNMTEDNTEPKAKSPVKIHLKTPVKTPLKSLVPYESASEEEEAPLPNPRQSPGGEDFSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSEEDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRKDEVDAIDDDDDAVVVEGAPVKIPTPNKTHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNVTSNGSTVNELLKQSYRGYGASVLSWNGKPAELEKEPFELVCAKRIAGHGSVEGSDIVEGSVAVDAAVTSSSNSNDVVVIAVALLVDAREQRQRDLDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGFSRFYNQNYRQNFQQRNKFKFNRFGGAGSAKFQQQRALQRHLSAGGGFSRRQPSAQQQQQT

Usp36

Ubiquitin carboxyl-terminal hydrolase 36

988 amino acids

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins.

Belongs to the peptidase C19 family.

108.676 kDa

MLHSLVPRYNKCVPFPTLRTDNNGARKQAEHPNNQSHHNHPHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMAKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISFKPRIDLSKYAARSPAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPITMQNVCNTNAYIMFFELDLSQAASPPANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPPVGANGYTNGNAQKTAIQFKQQNQQNGLQLGTGKFQDTAKPPLVGAYAKGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIDDEMKPGPTTAQLPSMPNMTEDSTEPKAKSPVKIHLKTPVKTPLKSLVPYESASEEEEAPLPNPRQSTEGEDFSESDQESGQTNGHSKTNGSLTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSEEDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDAIDDDDDAVVVEGAPVKIPTPNKTHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNVTSNGSTVNELLKQSYRGYGASVLSWNGKPAELEKEPFELVCAKRIAGHGSVEGSDIVEGSVAVDAAVTSSSDSNDVVVIAVALLVDAREQRQRDLDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGFSRFHNQNYRQNFQQRNKFKFNRFGGQGSAKFQQQRALQRHLSAGGGFSRRQPSAQQQQQT