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Urm1

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
Length
124 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
13.788 kDa
Sequence
MAEPTPTTTLNIKIEFGGGLELLFSNQRSHKVSIPSLVPKDNTTSAKNPPPKDDLLKPADITYLIHHMRDHLLQEREELFVENGTVRPGILVLVNDTDWELEGEGDYVLKDGDEVVFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)
Length
122 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
13.549 kDa
Sequence
MSTDSNTMFLKIEFGGGLELLFSNQRSHRITIPSTVPADNNTSVTTKDAASPATRPADVTYLLHHLRDHLLKEREELFMENGTVRPGILVLINDTDWELEGEGEYLLKDGDEIVLISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Ajellomyces capsulatus (strain NAm1 / WU24)
Length
121 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
13.106 kDa
Sequence
MGSIASPSLSSSSQLLTITVEFTGGLESIFNNTRKHTLSIPATYPSPSTGEPEPTSVASLVHYLIENVMEDTRQELFVVDGAVRPGILVLINDADWELEGEEKYQIQQGDNILFVSTLHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
120 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
13.434 kDa
Sequence
MTTDTEINPESARPEAHGSLSVTVEFTGGLEMLFSNERKHSVTLPARLSDGGRPSISFLLEYLVKNVMKDERKELFMLEDNVRPGILVLINDADWELEGEEKYELQPADNIVFVSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Coccidioides immitis (strain RS)
Length
115 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
12.937 kDa
Sequence
MGSHMTGENGQLALLDITVEFTGGLEMLFSNQRKHKISLPSLDITGAPSNIAYLIKYLCQNLMKDERKELFVLDDSVRPGILVLINDADWELEGEEQYRIQQNDNILFVSTLHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
109 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog nit-1/uba4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as ahp1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
12.007 kDa
Sequence
MSDQKDQMIDITVDFSGGLEILFSNQKHHALSVPAQDAQGKPANVGFLINYLCQTLMTDPRADLFVLGGELRPGILCLINDCDWELEEEDAYVLQPGDNILFISTLHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1
Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP)
Length
107 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
12.098 kDa
Sequence
MSDDATIPITIEFSGGLEILFANQKKYNLSLPTKDESGEPATVAFLVRYLCDHIMKDPRKELFVLDDTVRPGILVLINEADWELEGEDKYQVQKDDHIMFVSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
107 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.784 kDa
Sequence
MSQDTVEIRVEFGGGTELLLAPPHEKKHTLTIPRTDTAGNETNVSFLIGHIRKNLITEREELFVDGDSVRPGILVLINNGDWELEGEGDYVLQDGDEVVFISTLHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
106 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.998 kDa
Sequence
MTTETLNIMVEFTGGLEMLFSDQRNHKLTIPQTDSKGDPVTVGWLVNYLCEEIMQDSRKDMFILDDHVRPGILVLINDADWELEGEASYVLQPNDNILFVSTLHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1
Organism
Botryotinia fuckeliana (strain B05.10)
Length
106 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.787 kDa
Sequence
MATDTLSIVVEFTGGLEMLFSDQRSHKLSVPKTDSKGAPVTVGWLVNYLCDEIMQDSRKDMFVLDDHVRPGILVLINDADWELEGEASYELQSNDNILFVSTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila grimshawi
Length
104 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.675 kDa
Sequence
MGSKETPDLKIILEFGAGAELLFGNIKKRQLSLNGAQKWTIAELLKWMHANILTERAELFIQGDTVRPGILVLINDTDWELLGELEYELQPNDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila mojavensis
Length
104 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.795 kDa
Sequence
MSNNNTPDLKIILEFSAGAELLFGNIKRREICLDGTQKWTIANLLKWMHANILTERPELFIQGDTVRPGILVLINDTDWELLGELEYELKANDNVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
103 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.598 kDa
Sequence
MVNVKVEFLGGLDAIFKKQRVHKLTLKKNNSDDEPVTVGDLIDYIVENMIEDKNDVEVFLQNGTVRAGILTLINDTDWELEGEKEYELEDGDIISFTSTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila sechellia
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.531 kDa
Sequence
MGTPELKIILEFSAGAELLFGNIKRRELTLDGNQKWTIANLLKWMHANILTERPELFLQEDTVRPGILVLINDTDWELLGELDYELQPNDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila simulans
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.547 kDa
Sequence
MGTPELKIILEFSAGAELLFGNIKRRELTLDGNQKWTISNLLKWMHANILTERPELFLQEDTVRPGILVLINDTDWELLGELDYELQPNDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila yakuba
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.457 kDa
Sequence
MGTPELKIILEFSAGAELLFGNIKRRELVLDGNQKWTIANLLKWMHANILTERPELFLQGDTVRPGILVLINDTDWELLGELDYELQPNDNVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Homo sapiens
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.38 kDa
Sequence
MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPWDIRNLLIWIKKNLLKERPELFIQGDSVRPGILVLINDADWELLGELDYQLQDQDSVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.427 kDa
Sequence
MVRVIIEFLGGLDVIVKKQRQYKVDVQLDGKDEINVGDLIQWIVDNLIEHEGDVNVFLENDSIRPGILTLINDTDWELEGEKEYVLEDGDVVSFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.133 kDa
Sequence
MPIKIKVEFLGGLDVIASSVRDHKVTLPYEEGEATMKEAVNYIAENLVTDPKDIPVFIEDGTVRAGILVLINDTDWELEGKEDYLVENGDVLIFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Zea mays
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.237 kDa
Sequence
MHLTLEFGGGLELLLENSTKVHKVEVTTPKDGQGKVTMKFLLSWVKENLIKERPEMFLKADSVRPGVLVLINDCDWELCGGLDAELEEKDVVVFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1
Organism
Mus musculus
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.323 kDa
Sequence
MAAPLCVKVEFGGGAELLFDGVKKHQVALPGQEEPWDIRNLLVWIKKNLLKERPELFIQGDSVRPGILVLINDADWELLGELDYQLQDQDSILFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.204 kDa
Sequence
MGFKVKVEFLGGLDVISNKVREHSLKVPLEEGEATVKDLIELITKSIIADPKDIPVFIEDDTVRPGILVLINDTDWELEGMEEYVLESGDVFTFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Bos taurus
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.283 kDa
Sequence
MAAPLSVEVEFGGGAELLFDGVKKHQVTLPGQEEPWDIRSLLVWIKKNLLKERPELFIQGDSVRPGILVLVNDADWELLGELDYQLQDQDSVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.171 kDa
Sequence
MAIKIKVEFLGGLDIISNSVREHKCVIPFEEGEATVADLITYITKNIISDPKDIPVFIEDGTVRPGILVLINDTDWELEGMEEYVIESGDVFTFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Capra hircus
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.283 kDa
Sequence
MAAPLSVEVEFGGGAELLFDGVKKHQVTLPGQEEPWDIRSLLVWIKKNLLKERPELFIQGDSVRPGILVLVNDADWELLGELDYQLQDQDSVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Gallus gallus
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.427 kDa
Sequence
MAAPVSLQVEFGGGAELLFDGVKKHQVTLPSQPEPWDIRNLLKWIKQNLLKERPELFMQGESVRPGILVLINDADWELMGELDYKLQDQDNVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.05 kDa
Sequence
MGIKVKVEFLGGLDVISNGVREHKCEVPLEEGEATMIDLIKYITATIISDPKDVPVFIEEGTVRPGILVLINDTDWELEGMEDYVVESGDVLTFTSTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila ananassae
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.402 kDa
Sequence
MGTAELKIILEFSAGAELLFGNIKRRQLALDGTKKWNIANLLKWMHANILTERPELFLQGDTVRPGILVLINDTDWELLGELDYELQPNDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila erecta
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.429 kDa
Sequence
MGTPELKIILEFSAGAELLFGNIKRRELALDGNQKWTIANLLKWMHANILTERPELFLQGDTVRPGILVLINDTDWELLGELDYELQPNDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila melanogaster
Length
101 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3 (By similarity). The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U (By similarity). Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1 (PubMed:26715182, PubMed:28953965). The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates (By similarity). Plays a role in the regulation of JNK signaling in response to oxidative stress (PubMed:26715182).
Similarity
Belongs to the URM1 family.
Mass
11.486 kDa
Sequence
MGTPELKIILEFSAGAELLFGNIKRRELNLDGKQKWTIANLLKWMHANILTERPELFLQGDTVRPGILVLINDTDWELLGELDYELQPNDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila willistoni
Length
100 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.175 kDa
Sequence
MANDLKLILELSAGAELLFGNIKRRQLSLDGSQKWTIGSLLKWMHANILTRSPELFIQGDTVRPGILVLVNDTDWELLGGLDYELQQNDNILFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Oryza sativa subsp. indica
Length
100 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
10.986 kDa
Sequence
MHLTLEFGGGLELLLEKSTKVHKVDLQPNDGDGKVVMKGLLAWVKSNLIKERPEMFLKGDSVRPGVLVLINDCDWELCGGLDAELEEKDVVVFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Oryza sativa subsp. japonica
Length
100 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
10.986 kDa
Sequence
MHLTLEFGGGLELLLEKSTKVHKVDLQPNDGDGKVVMKGLLAWVKSNLIKERPEMFLKGDSVRPGVLVLINDCDWELCGGLDAELEEKDVVVFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
100 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.07 kDa
Sequence
MVQVQVEFLGGLDVIFSKQRKHQVSVEGANGSVTVGDLIDYIVSNMIQKQKDVSVFLEDNTIRPGILTLINDTDWELEGEKEYVLEDGDIVSFTSTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila virilis
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.333 kDa
Sequence
MPDLKIILEFSAGAELLFGNIKRRELALDGDQKWTIANLLKWMHANILTERPELFIQESTVRPGILVLINDTDWELLGELDYELQQNDNVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.171 kDa
Sequence
MQITVEFSGGLETAFDGNKKHVLDVPEGSSVNWLLHHMVETLMPDHKREEGKNIFLQDESVRPGVLVLINDSDWELEGEDQYILQPRDVIIFASTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Saccharomyces cerevisiae (strain RM11-1a)
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.028 kDa
Sequence
MVNVKVEFLGGLDAIFGKQRVHKIKMDKEDPVTVGDLIDHIVSTMINNPNDVSIFIEDDSIRPGIITLINDTDWELEGEKDYILEDGDIISFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.028 kDa
Sequence
MVNVKVEFLGGLDAIFGKQRVHKIKMDKEDPVTVGDLIDHIVSTMINNPNDVSIFIEDDSIRPGIITLINDTDWELEGEKDYILEDGDIISFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Indirectly involved in regulation of budding and haploid invasive growth.
Similarity
Belongs to the URM1 family.
Mass
11.028 kDa
Sequence
MVNVKVEFLGGLDAIFGKQRVHKIKMDKEDPVTVGDLIDHIVSTMINNPNDVSIFIEDDSIRPGIITLINDTDWELEGEKDYILEDGDIISFTSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Chlamydomonas reinhardtii
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
10.925 kDa
Sequence
MVKVKIEFSGGLELLFGNQKQHDVDVPVQEGKQLTAGHLIAWTRDNMLRERPELFVKGHTVRPGILVLINECDWELSGATESTISDGDVVVFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila persimilis
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.347 kDa
Sequence
MDDLKIILEFSAGAELLFGNIKRRQLFLDGHKKWTIANLLKWMHANILTERPELFLQGDTVRPGILVLINDTDWELLGELDYELQANDNVLFISTLHGG

Gene
Urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Drosophila pseudoobscura pseudoobscura
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.347 kDa
Sequence
MDDLKIILEFSAGAELLFGNIKRRQLFLDGHKKWTIANLLKWMHANILTERPELFLQGDTVRPGILVLINDTDWELLGELDYELQANDNVLFISTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
98 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.125 kDa
Sequence
MVKVRVEFLGGLDVIVNKQRVYDLDVPSQVENVGDLIDYIIENLITNKKDVEVFIENDSIRPGIITLINDTDWELENEKEYVIEDGDVISFTSTLHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
97 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
10.717 kDa
Sequence
MAIKVELLGGLDLLFNKQKALSLSLSNLGSTKLGSLIDYMAQIIEKPSQKDLFILNGTVRPGIIVLVNDQDWELLEKEEYNLEEGDEVVFVSTLHGG

Gene
URM1
Protein
Ubiquitin-related modifier 1
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
96 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
10.927 kDa
Sequence
MKFRFNGASNVELNNREIELTREEVEGSSIATVGDALRYLFGKYAETRDSFFDHHGELVHGTICIINKMDWEILEKERSPVKHGDHIVLISTIHGG

Gene
urm1
Protein
Ubiquitin-related modifier 1 homolog
Organism
Dictyostelium discoideum
Length
96 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.008 kDa
Sequence
MKVKIELSGGLELLFDKKKVHEIEFSDKNEIPLKDLILYMRDNLLKERSELFVVDDTVRPGILVLINDADWELFGGISYNVEDKDTIIFISTLHGG