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UVSSA

Gene
uvssa
Protein
UV-stimulated scaffold protein A
Organism
Xenopus tropicalis
Length
743 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity).
Similarity
Belongs to the UVSSA family.
Mass
84.679 kDa
Sequence
MDQKLSELVEVLTTSGEPQLNPEKLKELKKICRSSDEHINHVYHLLMTQLNQEHAEIRLSAFQIVTELFARSHLFRTLLISNFQEFLELTVETDHEQPLPPPKEVAQKMKILAIKTVQEWHEKFGEAYKKLSLGYHFLKQNKKIDFQDVRSRTQAERKREEEKQRRLENIYKEKVKKATAEMEDMLEEIQSSLTEMENCFRLLLPDPREFAVFTDEKDFASDMRTKPTSQSPSHSKSTSQSSAYSKSTSQVSFDNDDEQPCCSKNLPPFPSSCTSSASGAERSLGEGAKESDKSARKSDTDDSDGDYEGSREAFLRDHGLGSHAYSLSLEISTDLKVNENENNTDVLNNLMDAHKLLKQKYWPAVQSWIQLFTKAGTNSESLKCAIDVKKEIEAALKKYKEMNIDCHTKERKVMTASDDDDDDDEFEEVPEKEGYEPHIPDHLREEYGLEPSASKQPGKKTEVKRPNVPQVPPSQKRINDELNPTCAAATMKTMKDKMAKALPGSSRNAGEPKSKCPKRETDLSQAPVAPCGLDLHHWGEEQPSAGKMLKFSSLHRFWAPNEVDEEVESKELEALVKTRYVTLPGKFEPVKHKCLAPMPNGSLCERQDRYKCPFHGKIVPRDAIGVPINAEDRAREAREKFEKQGEEQDWRDPELMREIEQATGVDLGSSKCPVKGKGKGVKRNLKKKYPNLTDLKQKANTSRSRLEKKVFNTGSVKRVISAMNQADKRRHEKFANQFNYALN

Gene
UVSSA
Protein
UV-stimulated scaffold protein A
Organism
Gallus gallus
Length
730 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity).
Similarity
Belongs to the UVSSA family.
Mass
83.841 kDa
Sequence
MDQRLAQLVEELTTAGEPQLEPGRMKELKKICRSSEEHLSHAYHLLLTRLHEEHAEMRFSAFQIVQELFSRSHLFRTLLVSNFQEFLELTVGTDHEQPLPPPREVAQKLRKAAIAAVQGWHEKYGEAYKKLSLGYHYLKQNKKVDFQDVHARTVAERKREEEKQKRLDNVYKEKAKRAEKEMAEMSQEVAGTLTEMENCFRLLLPDPFDFTVNSTGLEPNEQTSADEDRSASSLPTYVGCVDDEQPCCSKDILPISQCVRTDQNEELADKQKKPEQDLLDGDTCSEVESGVPVLGDDDYETFVRNHGLISHKYALDLELSTADIKVHENEDNTAVINSVADAHKLVRNKFLPSVQSWIQLFTRAGINDDRLRCAIDLKNRLEAALRKYKEMNISFKERKRKVMKASDDGDDDDDDEDDFVEVPEKEGYEPHIPDHLRKEYGLENCPKKDESVKKDSCSLTKTKQKNEDELDPTCAAATLKLIRDKLPNESATTEPAALEEPDSKRRKLEEERAKAPLMPFGLDLHYWGQDQPSAGKILKFTSEHRFWAPSEVEEEVENKEITEMLKTRYITFAGKFEPVKHKCRAPMPDGSLCERQDRIKCPFHGKIIPRDECGVPINAEDRAREEKMRFEKQATQPETEWRDPEFMREVEAATGVDLGSSKTNGKGGKKKGKKKYPNLTDLKQQANTARSRLEKIVFNKGAVKRVVKAMNQMDQRKHEKFANQFNYALN

Gene
uvssa
Protein
UV-stimulated scaffold protein A
Organism
Danio rerio
Length
721 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity).
Similarity
Belongs to the UVSSA family.
Mass
83.342 kDa
Sequence
MDQTMRDKLSQLVEELTTSGEPQLNQDKMKEVKKICRVSDSYIDHFYHLIMTQLNQEHAEIRLSAFQMVNEVFSRSHHFRVLLITNFQEFLELTVETDAEQPLPPPKEVARKLRTLAIQTVQSWHATYGEAYKKLSLGYHFLKQIKKVDFQDVEARTLAERKRQEEKQKRLERIYKEKLDKAKQEMEEMTSGIEETLTEMNNCIRLLATDDFNLFDEDSAASISTTAEDQSDQPCCSKDLSNEHNGKMMEKKTDKEQTDESSDESDMEEVPDEDAFLRSTGLMSYRYQLELDVSADLKVRETEENEALVNTVRDLHRLVTTRHLPLVQSWVQVFTKVGVEEELMRRATELKKSLEHVLRKHEYLHIDYKDRERLVMRAPEDGEDDDDDFVDVPEKEGYEPHIPEHLRTEYGLDETPSTSTSGTKAKPSRPVVKCAVPPVSSSLSRLKRRMCDEEQDPTCAAATLRVLKQKLHPAPSTSVPDGSSESAVSSSDQSNMTKNKASFKAPVIPFGMDLYYWGEEQPTAGKIIKQTSQHQFWVPHEVEEEVENKELSAQMKSRCITYAGKFKPVEHKCKAPMPNGSLCERQDRVKCPFHGHIIPRDELGRPVNPEDALRLEREKRKREEEQPDWRDPELMREIEAATGEDLGSSKTYGKGKKGNKGKSKKKYPNLTDLKQKANTSRSRLEKKVFNKSSMRRVTEVMNKMDKRKHEKFANQFNYALN

Gene
Uvssa
Protein
UV-stimulated scaffold protein A
Organism
Rattus norvegicus
Length
720 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity).
Similarity
Belongs to the UVSSA family.
Mass
82.035 kDa
Sequence
MDQKLSQLIEELTTSGESQLNAQKMKELKKICKSSEEQLSHAYRLLMTQLTQDHAEIRLSAFQIVDELFTRSHQFRVLLVSDFQEFLELTLGTDNDHPLPPPREAAQRLRQAAMQAVEGWNEKFGEAYKKLALGYHFLKHTKKVDFRDINVRTLAERKREEEKQKHLDKIHRESADRAKREMEEMSDEIGCCLTEVENCFRLLVPLDLGPYREDKFFGEASGIAEDHAPCAWSPDLATPRGSGLSGPQDEEQPCCSKDLVASAHHAGSAVGLKAPAPAATEDPCRDEDRHSEHSDPEDFLRSHGLGSHKYTLDVELPSDGLKVQENEDNLAVLHAARDSLKLIQNKFLPAVCSWVQRFTRAGIYSGHLKQAIDLKMELELALKKYEELNIEPGRGQRSRTEALEDSEEEDQDFVEVPEKEGYEPRIPDHLRAEYGLEPKAPLKTLEKHTAVCSVQERTRRRREEEASDPTSAAAQMLRLQDCLSSPSSSSTRGPLGPEEAQKQAERARAPMVPFGVDLCYWGQEQLTAGKILKSDSQHRFWKPHEVEEEVDSAHVSEMLHSRHITFSGKFEPVQHKCRALRPNGRLCERQDRLKCPFHGKIIPRDDKGQPLNPEDRAREQRQQLQQQRAHPDWQDPEFMKDVEAATGVDLGSSKYSKKGKGKKKKHPNLTDLRERANTARARLEKKVFAKGAVQRVVAAMNQMDQKKHEKFANQFNYALK

Gene
Uvssa
Protein
UV-stimulated scaffold protein A
Organism
Mus musculus
Length
717 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity).
Similarity
Belongs to the UVSSA family.
Mass
81.759 kDa
Sequence
MDQKLSQLIEELTTSGESQLNAQKMKELKKICKSSEEQLSHAYRLLITQLTQGHAEIRLSAFQIVDELFTRSHQFRMLLVSDFQEFLELTLGTDSDRPLPPPREAAQRLRQAAMQAVEGWNEKFGQAYKKLALGYHFLKHTKKVDFRDINVRTVAERKREEEKQKHLDKIHRESADRAKREMEEMYDEIECCLTEVENCFKLLVPLDFVPCPEDKFFGEASSMTEGYAPCPLSPDLATPRESGLSGPQDEEQPCCSKDLVASAYHVGSVVGLKALPQTAMKDSSRDEDEPSDPDDFLRSHGLGSHKYTLDVEVPSDGLKVQENEDNLAVLHAARDSLKLIQNKFLPTVCSWVQRFTRAGTYSAHLKQAIDLKMELELALKKYEELNIEPGRGQRSRTEALEDSEDEDQDFVEVPEKEGYEPRIPDHLRAEYGLEPKAPLKTLEKGTAVCKLQERTRMRREEEASDPTSAAAQMLRLQDCLSSPSPSSTRVLPGPEEAQKQAERARAPIVPFGVDLCYWGQEQLTAGKILKSDSQHRFWKPSEVEEEVDSAHVSEMLHSRHITFSGTFEPVQHKCRALRPNGRLCERQDRLKCPFHGKIIPRDDKGQPLNPEDRAREQRQQLQRQQAHPDWQDPEFLKDVEAATGVDLGSSRSSKKGKGKKKKHPNLTDLRERTNTARARLEKKVFAKAAVQRVVAAMNQMDQKKHEKFANQFNYALK

Gene
UVSSA
Protein
UV-stimulated scaffold protein A
Organism
Homo sapiens
Length
709 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
Similarity
Belongs to the UVSSA family.
Mass
80.591 kDa
Sequence
MDQKLSKLVEELTTSGEPRLNPEKMKELKKICKSSEEQLSRAYRLLIAQLTQEHAEIRLSAFQIVEELFVRSHQFRMLVVSNFQEFLELTLGTDPAQPLPPPREAAQRLRQATTRAVEGWNEKFGEAYKKLALGYHFLRHNKKVDFQDTNARSLAERKREEEKQKHLDKIYQERASQAEREMQEMSGEIESCLTEVESCFRLLVPFDFDPNPETESLGMASGMSDALRSSCAGQVGPCRSGTPDPRDGEQPCCSRDLPASAGHPRAGGGAQPSQTATGDPSDEDEDSDLEEFVRSHGLGSHKYTLDVELCSEGLKVQENEDNLALIHAARDTLKLIRNKFLPAVCSWIQRFTRVGTHGGCLKRAIDLKAELELVLRKYKELDIEPEGGERRRTEALGDAEEDEDDEDFVEVPEKEGYEPHIPDHLRPEYGLEAAPEKDTVVRCLRTRTRMDEEVSDPTSAAAQLRQLRDHLPPPSSASPSRALPEPQEAQKLAAERARAPVVPYGVDLHYWGQELPTAGKIVKSDSQHRFWKPSEVEEEVVNADISEMLRSRHITFAGKFEPVQHWCRAPRPDGRLCERQDRLKCPFHGKIVPRDDEGRPLDPEDRAREQRRQLQKQERPEWQDPELMRDVEAATGQDLGSSRYSGKGRGKKRRYPSLTNLKAQADTARARIGRKVFAKAAVRRVVAAMNRMDQKKHEKFSNQFNYALN

Gene
UVSSA
Protein
UV-stimulated scaffold protein A
Organism
Bos taurus
Length
685 amino acids
Function
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity).
Similarity
Belongs to the UVSSA family.
Mass
76.862 kDa
Sequence
MDQKLSELVEELTTSGEPQLNPEKMKQLKKICKSSEEQLGHAYHLLMAQLSQEHAEIRLSAFQVLDQLFARSHQFRTLVVSNFQEFLELTLGTDHERPLPPPREVAQRLRQAATQAIRGWNEKYGAAYKKLALGFHFLKHSKQVDFQDVDARTVAERKRAEERQKRLDRIYKERSEWAAREMEEMSTEIRGCLTELESCFRLLLPFDLDLAPGAAWCPVPEKGDRDEEQPCCSKSLAACAHHPGAMDAGGPPSEDEDRDPDGFVRRHGLGSRQYTLDVELSSDSLRVRENEDNSAVIRAARDALRLIQNKLLPAACSWVQLFTRAGTYGGHLEGAIHLKAELEAALKRSRELDIVPEEGRSGETAAPGDEDEDEDDFVEVPEKEGYEACVPEHLRPECGEQRHGPGRGLEEGLAAPGSQARKRPGSDMEAFDPTSAAAQQQWPRPHGPPASPPSPRAPLAPEQAAWRAAEQARAPVVPFGVDLCYWGQEELMAGKILKCDSEHRFWKPCEVDAEVESASVSEALRSRRITFAGQFEPVQHRCRAPRPDGQLCARQDRLKCPFHGKIIPRDDAGRPLNAEDRAREQRQQLQRPAGRPDWQDPEFLRDVEAATGVDLGSSRPGGKGKGKRRKHSGLTDLKRQADTARARIAKKVFAKAAVQRVVTAMNQMDEKKHEKFANQFNYALN