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USP37

Gene
USP37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Gallus gallus
Length
986 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity).
Similarity
Belongs to the peptidase C19 family.
Mass
110.863 kDa
Sequence
MAPLKVHGPVRMRSMQTGITKWKEGSFEIVEKDNKVSLVVHYNVGGIPKTFQLSHNIKSVTLRPNGRKLCCLMLTLKDTSFLTIDKVPLKDANEMRMYLDAVHQDRVHTAGKPSQGSGSFGGVLGSRTTQKEANRQFSYIENQAPPKRVTVESKDETPFRKVLGTPARASVKNSSGTGAPSNRVNVAASPTSSVPHRTGLLESRSEKRKRAQPPSSEMSEDYPKENDSSTNNTAMSDPAWKYLNSSREKQLKLKQEEENRTSGVLPLQSSSYYGSRSSSKEYSTSSSTLDRSSVSSQTTSAKRSLGFLSQPAPLSVKKMRSNQDYTGWNKPRVPLSTHPQQQLQGFSNLGNTCYMNAILQSLFSIQSFANDLLKQGIPWKKIPLNALIRRFAHLLAKKDVSSPEVKKELLKKVKSAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKSEPVPNDDSSPGRASDDLSATKVYTCPVISNLEFEVQHSIICKTCGETVTKREQFNDLSIDLPRRKKLFPSRSIQDSLDLFFRAEEIEYSCEKCNGKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTESTRLPLTLGWSAHSAISRPLKASQMVNSCTISTSTPCRKGRFLRKEGLSELRSSTGRKNLNRVHVFKEDVQDINSSLQVQRGIRKSSKRSKMEGDKPELGNAGFDGMSEDELLAAVLEISKREASLSLSHDEDKPTSSPDTGFGDDEIQELPENLETMETEKPKAPLESGPANFTEITKDFDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAREQKEDDDLKRATELSLQEFNSSLLDSVGSDEDSGNEDVLDMEYSEAEAEELKRNAETGELPHSYRLISIVSHIGSTSSSGHYISDVYDIKKQSWFTYNDLEVSRTLETTVQCDRDRSGYIFFYMHKDIFDELLETEKNAQPLSMEVGRSIRQPL

Gene
USP37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Sus scrofa
Length
982 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
Similarity
Belongs to the peptidase C19 family.
Mass
110.483 kDa
Sequence
MSPLKIQGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLNAVAMKPSQGSGSFGAILGSRTSQKETHRQLSYSDNQVSSKRGSLETKDDIPFRKVLGNPGRASIKTAAGSGITATRTIPSLTSTSTPLRSGLLENRTEKRKRMLSSGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAASKDYSPSSTNLDRTNISSQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRLPLSSHQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALISRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVPGEENSPDVTATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFNLGWSAQMAISRPLKASQMVNSCITSPSTPSKNFTFKSKSSLALSLDSDSEDELKRSVALSQRLCEISSSEQQQEDLEKDSKSCKLEPDKSELENSGFDAMSEEELLAAVLEISKREASPSPSHEDDDKPTSSPDTGFAEDDIQEMPENPDPMETEKPKTITEPDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFLDSLGSDEDSGNEDVLDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEASVQSDRDRSGYIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAS

Gene
USP37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Bos taurus
Length
981 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
Similarity
Belongs to the peptidase C19 family.
Mass
110.398 kDa
Sequence
MSPLKIHGPIRIRSMQTGITKWKEGSFEVVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLNAAMKPSQGSGSFGAILGSRTSQKETNRQLSYSDNQVSSKRGSLETKDDTPFRKVLGNPSRGSIKAAAGNGVTPARTIPSLTSTSTPLRSGLLENRTEKRKRMLSSGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRTAAKDYSPGSTNLDRTNISSQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKIEPVPGEENSPDISATRVYTCPVITNLEFEVQHSIICKVCGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFNLGWSAQMAVSRPLKASQMVNSCITSPSTPSKNFTFKSKTSLALSLDSDSEDELKRSVALSHRLCEMSGSEQQQEDLEKDSKSCRIEPDKSELENSGFDGMSEEELLAAVLEISKREASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDSVETEKPKTITEPDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDSLGSDEDSGNEDVLDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEASVQSDRDRSGYIFFYMHKEIFDELLETEKNSQALNLEVGKTTRQVS

Gene
USP37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Canis lupus familiaris
Length
981 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
Similarity
Belongs to the peptidase C19 family.
Mass
110.453 kDa
Sequence
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLHAAMKPSQGSGSFGAILGSRTSQKETNRQLSYSDNQASSKRGSLETKDDIPFRKVLGNPGRGSIKTATGSGITVTRTIPSLTSASTPLRSGLLENRTEKRKRMLSSGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRTGSKDYSSGSTNLDRTNVSGQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVPGEENSPDISATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKNFTFKSKSSLALCLDSDSEDELKRSVALSQRLCEMSGCEQQQDDLEKDSKPCRIEPDKSELENSGFDGMSEEELLAAVLEMSKREASPTLSHEDDDKPTSSPDTGFAEDDIQEMPENQDPVETEKPKTVTEPDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFLDSLGSDEDSGNEDVLDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEASVQSDRDRSGYIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAL

Gene
USP37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Homo sapiens
Length
979 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
Similarity
Belongs to the peptidase C19 family.
Mass
110.17 kDa
Sequence
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSFGAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIARTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKRSLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSVALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLETEKNSQSLSTEVGKTTRQAL

Gene
Usp37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Mus musculus
Length
979 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
Similarity
Belongs to the peptidase C19 family.
Mass
110.063 kDa
Sequence
MSPLKIYGPIRIRSMQTGITKWKEGSFEIVEKDNRVSLLVHYNTGGIPRVFQLSHNIKNVVLRPSGIKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLHAAMKASQGSGSFGTILGSRTSQKETNRQLSYSDNQASSKRGSLETKDEIPFRKVLGSPGRGPIKTVTGGGMAVTRTIPSLTLTSTPLRSGLLENRTEKRKRMLSGSELTEDYPKENDSSSNNKAMTDPSRKYLTSCREKQLSLKQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGVTNLDRCNVSSQTPSAKRSLGFLPQPTPLSVKKLRCNQDYAGWNRPRVPLSSHQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQSIPWKKIPFNALIRRFANLLIKKDICNSETKKELLKKVKNAISATAERFSGYVQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVLGEENLPDTSATKVFTCPVITNLEFEVQHSIICKACGETIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKLGQQVIIPRFLTLASHCTESTKPPVTLGWSAPVAISRPLRACQMMNSCITSPSAPSKKFTFKSKSSVTSCLDSDSEDELKRSVVLSQRLCDLPGNEQYQEDVEKDLKLCRLEPGKAELENSGFDRMSEEEVLAAVLEISRREASPVLSPEDDDKPTSSPDTGFAEDDIPEMPENPDAMEIEKSKTITEPGPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDVDREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFLDSLGSDEDSGNEDVFDMEYTEAEAEELKRNAETGALPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLETEKTSQALSMEVGRAARQAS

Gene
usp37
Protein
Ubiquitin carboxyl-terminal hydrolase 37
Organism
Danio rerio
Length
937 amino acids
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity).
Similarity
Belongs to the peptidase C19 family.
Mass
105.264 kDa
Sequence
MAAAVPRLTSGGAVRIRIRCGELGTTKWREGVIEIQERDNKINLLVKFNSGGAPRVFQLSHNVKSVSWFQTHGPNRMTLTLKDSCIVMMDKLNMLVAKKMKEYLETVKLGKPAVFKTNQGSASFGLVLGNRTAQNDSGLSPSDKQSAPRRSSLDSREDSTPRKPLGSPSRVTSTPARGSLSEIRSEKRKRLMNSDGDLTEDYPKENDSSSNNKAITDSSRKFLLSCKDKLKQSEENRASAPHTPAPLQPTSFYGSRTGAKDYTQTHSFLDRPSSTGSCPSAKRSLVLPNHSTPFKKVRPTLDYGGWNKPRPSVLAQPQPPLQGFSNLGNTCYMNAILQSLFSLPSFSNDLLKQGIPWKRVPINALLRRFAHLLAKKDISPPEVKKDLLRRVKNAISSTAERFSGYMQNDAHEFLSQCLDQLKEDVEKINKSWKNEPSAWDEPQSTRLADEVDTSRIYTCPVTVNMEFEVQHTITCKSCGEVVLKREQFNDLSIDLPRRRKTLPMRSIQDSLDLFFRMEEIEYSCEKCSGKAATVSHKFSRLPRVLILHLKRYSYNTQLSLNSKLGQQVLIPKYLTLLSHCTDATRSPLSLGWSAQNALSRTLKISQSVNSSTLRRASQRPESSGSVLCDSDSDEELVRKVARKHHPDDDRADELQQHHPHAAVEQSEFNGINDEEMLAAVLEMSRHDTSLCAGPDEEPSSSPDTGFGDADAHDLTQHLELLDAEKQPTDALESLDLTMDENKENQTPDGLQGELDWVQQYSLEQEREEQELQQALAQSLQEQEAREMREDDDLKRATELSLQEFNNSLPELLCSDEDSGNEDGLDMEYSEAEAEELKKNAETGELPNSFRLISVVSHIGSSSSSGHYISDVYDMKKQSWLTYNDLDVSRTQESTVQRDRDRSGYIFFYMHKDVFEELSELEKAGVNTDGGRTVLQPL