Protein
Ubl carboxyl-terminal hydrolase 18
Function
Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.
Similarity
Belongs to the peptidase C19 family.
Sequence
MSKAFGLLRQTCQSILAESPQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLMKDQITDVHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLPLSLFDVDSKPLKTLVGQEDALHCFFQPRELSRKSKCFCENCGKKTHRKQVLKLTHFPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQVLPTKQKSCDAEEQPGGQFELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC