Protein
Membrane glycoprotein US10
Organism
Human cytomegalovirus (strain Merlin)
Function
Plays a role in the modulation of host immune response by down-regulating the surface presentation of HLA-G molecules. Selectively targets HLA-G molecules for degradation by a mechanism distinct from the one used by US11.
Similarity
Belongs to the HHV-5 US6 protein family.
Sequence
MLRRGSLRNPLAICLLWWLGVVAAATEETREPTYFTCGCVIQNHVLKGAVKLYGQFPSPKTLRASAWLHDGENHERHRQPILVEGTATATEALYILLPTELSSPEGNRPRNYSATLTLASRDCYERFVCPVYDSGTPMGVLMNLTYLWYLGDYGAILKIYFGLFCGACVITRSLLLICGYYPPRE