About Products Protein Database Contact

US1

Gene
US1
Protein
Transcriptional regulator ICP22
Organism
Human herpesvirus 2 (strain HG52)
Length
413 amino acids
Function
Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response.
Similarity
Belongs to the herpesviridae ICP22 family.
Mass
44.739 kDa
Sequence
MADIPPDPPALNTTPANHAPPSPPPGSRKRRRPVLPSSSESEGKPDTESESSSTESSEDEAGDLRGGRRRSPRELGGRYFLDLSAESTTGTESEGTGPSDDDDDDASDGWLVDTPPRKSKRPRINLRLTSSPDRRAGVVFPEVWRSDRPIRAAQPQAPASLPGIAHAHRRSARQAQMRSGAAWTLDLHYIRQCVNQLFRILRAAPNPPGSANRLRHLVRDCYLMGYCRTRLGPRTWGRLLQISGGTWDVRLRNAIREVEAHFEPAAEPVCELPCLNARRYGPECDVGNLETNGGSTSDDEISDATDSDDTLASHSDTEGGPSPAGRENPESASGGAIAARLECEFGTFDWTSEEGSQPWLSAVVADTSSAERSGLPAPGACRATEAPEREDGCRKMRFPAACPYPCGHTFLRP

Gene
US1
Protein
US1 protein
Organism
Equine herpesvirus 1 (strain Kentucky A)
Length
303 amino acids
Similarity
Belongs to the herpesviridae US2 family.
Mass
33.503 kDa
Sequence
MGVVLITVVTVVDRHKALPNSSIDVDGHLWEFLSRQCFVLASEPLGIPIVVRSADLYRFSSSLLTLPKACRPIVRTRGDTAIALDRNGVVYHEDRMGVSIEWLSVLSGYNHLNSSLIINQPYHLWVLGAADLCKPVFDLIPGPKRMVYAEIADEFHKSWQPPFVCGKLFETIPWTTVEHNHPLKLRAAGGEDTVVGECGFSKHSSNSLVHPPTVNRVIYAVVDPARLREIPAPGRPLPRRRPSEGGMRAPRRRSRAPAPARSTAAAATPPRPGDPRAPAARRAGDVTWMERLLWGVFGRTSTR

Gene
US1
Protein
Transcriptional regulator ICP22 homolog
Organism
Human herpesvirus 2
Length
197 amino acids
Similarity
Belongs to the herpesviridae ICP22 family.
Mass
21.51 kDa
Fragment
single
Sequence
MADIPPDPPALDTTPANHAPPSPLPGSRKRRRPVLPSSSESEGKPDIESESSSTESSEDEVGDLRGGRRRPPRELGGRYFLDLSAESTTGTESEGTGPSDDDDDDASDGWLVDTPPRKSKRPRINLRLTSSPDRRAGVVFPEVWRSDRPIRAAQPQAPAQSSGDRAHAPRRSARQAQMRSGAAWTLDLHYIRQCVNQ

Gene
US1
Protein
Uncharacterized protein HQLF3
Organism
Human cytomegalovirus (strain AD169)
Length
156 amino acids
Similarity
Belongs to the herpesviridae US1 family.
Mass
17.765 kDa
Sequence
MASGLGDLSVGVSSLPMRELAWRRVADDSHDLWCCCMDWKAHVEYAHPASELRPGSGGWPEHAEAQWRQQVHAAHDVWCNCGDWQGHALRSRSRTAESGRSSSSSSVSVLSDGDQQPWWRRLRVKRPKFPSWARRWTQRHDSEERASQQAENDSTS

Gene
US1
Protein
Protein US1
Organism
Human cytomegalovirus (strain Merlin)
Length
156 amino acids
Mass
17.765 kDa
Sequence
MASGLGDLSVGVSSLPMRELAWRRVADDSHDLWCCCMDWKAHVEYAHPASELRPGSGGWPEHAEAQWRQQVHAAHDVWCNCGDWQGHALRSRSRTAESGRSSSSSSVSVLSDGDQQPWWRRLRVKRPKFPSWARRWTQRHDSEERASQQAKNDSTS