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URM1-2

Gene
URM1-2
Protein
Ubiquitin-related modifier 1 homolog 2
Organism
Arabidopsis thaliana
Length
99 amino acids
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Similarity
Belongs to the URM1 family.
Mass
11.15 kDa
Sequence
MQFTLEFGGGLELLCDSVKIHKVNINLLNDSDILTMKDLLSWVRTNLIKERPEMFMKGDTVRPGVLVLVNDCDWELSGQLDTTLEDKDVIVFISTLHGG