URI1

Unconventional prefoldin RPB5 interactor 1

535 amino acids

Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Belongs to the RNA polymerase II subunit 5-mediating protein family.

59.832 kDa

MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKAKHRIAHKPHSKPKTSDIFEADIANDVKSKDLLADKELWARLEELERQEELLGELDSKPDTVIANGEDTTSSEEEKEDRNTNVNAMHQVTDSHTPCHKDVASSEPFSGQVNSQLNCSVNGSSSYHSDDDDDDDDDDDDDNIDDDDGDNDHEALGVGDNSIPTIYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSTGSGHSAQELPTIRTPADIYRAFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSAAEFDDRRGVLRSISCEEATCSDTSESILEEEPQENQKKLLPLSVTPEAFSGTVIEKEFVSPSLTPPPAIAHPALPTIPERKEVLLEASEETGKRVSKFKAARLQQKD

Uri1

Unconventional prefoldin RPB5 interactor

531 amino acids

Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination (By similarity).

Belongs to the RNA polymerase II subunit 5-mediating protein family.

59.084 kDa

MEPPSEPEPEPQPLAEASAAAPLRAPEVARLREEQEKVVTNCQEKIQHWEKVDNDYSALQERLRTLPDKLSYDVMVPFGPLAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDFKKVLKNFESRVEFTEDLQKMSDAAGDFVDIREEIKSDFEFKGKQRIAHKPHSKPKTSDIFEADFENGVKPKNTFDADELWARLEELERQEELLGELESKPDTVIANGEDRVSSEEEKEGADTGVNVVSPVTDSSAASSCKRRAGNAGLPNGQVNSLNYSVNGSNSYHSNKDDDEEEEDDDDDDDEDDDNESDHAISADNSIPTIYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKSGAGSHATHELPAIKSPADIYRVFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSAADVEDRRGLLRSTSSEEAVATEAGGSSLDELQENHPKKPLPSGVSEAFSGTVIEKEFLSPSLAPYSAIAHHALPTIPERKEVPSEVSEEPTKRVSKFRAARLQQRS

URI1

Unconventional prefoldin RPB5 interactor

524 amino acids

Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination (By similarity).

Belongs to the RNA polymerase II subunit 5-mediating protein family.

58.994 kDa

MEAPPDPRPHASAAAPLRAPEVARLREEQEKVVTNCQEKIQHWKKVDNDYNALQERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKTDFEFKAKHRIAHKPHSKPKTSDIFEAEFANDLKSKDLLADKELWDRLEELERQEELLGEIDIDSKPDTVIANGEDVSSEEEKEDQNINVNMMHQVTDSLALSSCYNSLTNSELFNGQVNSPLNYSVNGSSSYHSNEDDGDNNDDGGDSENDHDTLGVEDNSIPTIYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSSGSGHSPQELPMIRTPADIYRVFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSAADFDDRRGVLRSISCEEATCSDASESILEEEQENHQKKLLPLSVTPEAFSGTVIEKEFLSPSLTPHPAMAHPVLPTIPERKEVLSEVSEGTTKRVSKFKAARLQQKN