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URE2

Gene
URE2
Protein
Protein URE2
Organism
Kluyveromyces marxianus
Length
404 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
46.664 kDa
Sequence
MQQDMHNGGTGNTISNLSSALRQVNLGNSNTTTDQSNIAIDFNQQQLMEEVNQNSMNAFNIQQQHQQQQENVQKQQEQQQQQLQQQQQQQQQQQQQQQQQQQQQQQLQQQQQLQQHHHHQQRQQHPNNNVQAGTSQQQMLFQGANSIDSSRITKFFQNQPMEGYTLFSHRSAPNGFKVAIVLSELNMHYNTIFLDFNLGEHRAPEFVAINPNARVPALIDHNMDNLSIWESGAIILHVVNKYYRETGTPLLWSDNLADQAQINAWLFFQTSGHAPMIGQALHFRYFHSQKVKSAVDRYTDEVRRVYGVVEMALAERREALIMDLDSENAAAYSAGTTPLSQSRFFDYPVWLVGDKITVADLSFVPWNNVVDRIGINIKVEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Protein URE2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
389 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
44.395 kDa
Sequence
MQQDMQNGGPGNTISNLSSALRQVNLGNSNTTTDQSNISIDFNQQQLLEEANQGSINAYNAQQQQQEHLQQQAQQQQLHMQQLQQAQQQQAQQQAHQQQQQVHQVQHQHVQQDHMPIGQSQQQAMYQGPNPIDSSRITKFFQNQPMEGYTLFSHRSAPNGFKVAIVLSELNMHYNTIFLDFNLGEHRAPEFVAINPNARVPALIDHNMENLSIWESGAIILHVVNKHYKETGNPLLWSDSLADQAQINAWLFFQTSGHAPMIGQALHFRYFHSQKVKSAVDRYTDEVRRVYGVVEMALAERREALIMDLDSENAAAYSAGTTPLSQSRFFDYPVWLVGDKITVADLSFVPWNNVVDRIGINIKVEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Protein URE2
Organism
Saccharomyces paradoxus
Length
359 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
40.658 kDa
Sequence
MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSAGVNNNNNNSSSSNNNNNNNNNAQNNNSGRNGSQSNDNGNNIKDTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Protein URE2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
355 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
40.397 kDa
Sequence
MGDSRNTGTISNLSSALRQVNIGSGQDQKNINYEFSNGLNNNVNDNGNHNLVNTNEDNVNKDGSINTNMMSRQVPIQHTHGSQLLQQERMNEQQFNPMEYSRISKFFQNQPMEGYTLFSHRSAPNGFKVSIVLSELGLQYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGLENLAIWESGAILLHLVNKFYKETGNPLLWSDDLADQAQINAWLFFQTSGHAPMIGQALHFRYFHTQKIESAVERYTEEVRRVYGVIEMALAERREALIMELDTDNAAAYSAGTTPLSQSRFFDYPVWLVGDKLTIADLSFVPWNNVVDRIGINIKVEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Transcriptional regulator URE2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
354 amino acids
Function
Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Is also an atypical glutaredoxin without a catalytical cysteine residue. Has glutathione peroxidase and thiol:disulfide oxidoreductase activities in both native and fibrillar form. Also shows insulin disulfide reductase and dehydroascorbic acid reductase (DHAR) actvites.
Similarity
Belongs to the GST superfamily.
Mass
40.271 kDa
Sequence
MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Protein URE2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
354 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
39.044 kDa
Sequence
MQQEIRNSNTPNTGSGNPVSNLSSALRQVHLGNSNTTTDQSNISIDYTSRAPQQQPLDELSRGAAGGPAAGGGPEGSNMVGASSAAQVTAFGGPSVVDSSRITKFFQNQPMEGYTLFSHRSAPNGFKVAIVLSEMGLNYNTIFLDFNLGEHRAPEFVAINPNARVPALIDHSLDNLSLWESGAIILHLANKYYRETGTPLLWSDNLAEQAQINSWLFFQTSGHAPMIGQALHFRYFHSQKVPSAVERYTDEVRRVYGVVEMALAERREALIMDLDSENAAAYSAGTTPLTQSRFFDYPVWLVGDHITIADLSFVPWNNVVDRIGINIKVEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Protein URE2
Organism
Saccharomyces bayanus
Length
345 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
39.297 kDa
Sequence
MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFPSGVNSNNSVQNSNNGRNGTQNNNNENSIKDTIEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHNMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINVKIEFPEVYKWTKHMMRRPAVIKALRGE

Gene
URE2
Protein
Protein URE2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
344 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
39.136 kDa
Sequence
MMSTDQHIQQNMNDNSNNSNNSNNNNTNNNNNNQSVNVNVNNTNNNTQTISNLSAGLKSVSLTDQQQNEVNLNLLQQQLHQEASTQQQQSRITQFFQNQPTEGFTLFSHRSAPNGFKVAIILSELNLPFNTFFLDFNNGEQRTPEFVTINPNARVPALIDHYNDNTSIWESGAITLYLVSKYLKENGECSLWSNNLIEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRFFDHPVWLVGDRTTVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKHMMQRPAVKRALRGD

Gene
URE2
Protein
Protein URE2
Organism
Candida maltosa
Length
328 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
37.345 kDa
Sequence
MNMSDQRIPQNTGDNSNNSNSNNNNNNNNNTHTISNLSAGLKSVSLTDQQQNEVNLNLLQQQLHRESSNQQQQSRITQFFQNQPAEGYTLFSHRSAPNGFKVAIILSELNLPFNTIFLDFNNGEQRAPEFVTINPNARVPALIDHFNENTSIWESGAIILYLVSKYLKENGECSLWSDNLIEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVVEMALAERREALIMDLDVENAAAYSAGTTPLSQSRYFDYPVWLVGDRATVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKYMMRRPAVIRALRGD

Gene
URE2
Protein
Protein URE2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
308 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
34.996 kDa
Sequence
MTNNNSNSNNNQTISNLSAGLKSVNLADQQQNEVNLNLLQQQLQNEATTQQSQSRISQFFQNQPTEGYTLFSHRSAPNGFKVAIILSELNLPFNTIFLDFNNGEQRAPEFVTINPNARVPALIDHFNENTSIWESGAIILYLVSKYLKDNGECALWSDNLIEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRYFDYPVWLVGDRATVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKYMMRRPAVIRALRGD

Gene
URE2
Protein
Protein URE2
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
301 amino acids
Function
Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
34.109 kDa
Sequence
MSGAHTISHLSAGLKSVNIGDQQQNEANLNLLQQQLENEATSQTQQSRITQFFAQQPSDGYTLFSHRSAPNGFKVAIILSELELPFNTIFLDFNHGEQRAPEFVTINPNARVPALIDHFNDNTSIWESGAIILYLVSKYLRDNGECALWSDNIVEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRYFDYPVWLVGDRATVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKYMMRRPAVIRALRGD