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UMAG_11400

Gene
UMAG_11400
Protein
Thiamine thiazole synthase
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
341 amino acids
Function
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
Similarity
Belongs to the THI4 family.
Mass
36.269 kDa
Sequence
MTPPTASFINPATAGPQPGSFKLSKGSLHACSTTAAPKYEQYVPIKTGEEPIEDFNGHYRFAEIKESHTSRAMTARYMADMMDAAVSDVVIIGAGSAGLTCAYTLAKQRPDLRITMLEASVAPGGGAWLGGQLMSGMVIRKPAHNLLVEIGVPFDDEGSYVVVKHAALFTSTLMSKLLAMDNVKLFNATCCEDLIIKKDQTGAQRVNGVVTNWTLVTMAHGLQSCMDPQTITAPVVIGACGHDGPFGAFSVKRLSSAGLIKLGDMRPMDMNKSEGLIVNNTREVFPGLIVSGMELSEHDGHPRMGASFGGMIGSGQKAAYEAIKLYDSLEIDDGEVVGLKH