Protein
Ubiquitin-like-specific protease 1C
Organism
Arabidopsis thaliana
Function
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins. Regulates salt stress responses and flowering time. Redundant with ULP1D.
Similarity
Belongs to the peptidase C48 family.
Sequence
MKRQRAIELDRVKKTMLNIDWDDALGDEEVPELEIIATDKIPPREPTLSGYEPAVSVRSLRDNELDDHLKRQRSLLTRLGDKLADKGEKIRNRIGELEYEKQRRMFQQRTKMQDADNGCQILEKPKSSDVFMRASTASKDTSGQGTSGSKDVSRSTFAAHFSDNLKMGPQPVKLVNDKLQDLGRGSWISKANRDSIIEKNNVWRSLPRLSKCKVSLKNFYSESKDPKGDRRPNEAYGKGKPNESSPYLLVDDDDGDDDKVIGYETPRHWSLKASPLQSSSCRKKSDDKVINLDEDEPLSPMVVEEACELPEGLPEDIYYPSSDQSDGRDLVQVSLKDLKCLSPGEYLTSPVINFYIRYVQHHVFSADKTAANCHFFNTFFYKKLTEAVSYKGNDRDAYFVKFRRWWKGFDLFCKSYIFIPIHEDLHWSLVIICIPDKEDESGLTIIHLDSLGLHPRNLIFNNVKRFLREEWNYLNQDAPLDLPISAKVWRDLPNMINEAEVQVPQQKNDFDCGLFLLFFIRRFIEEAPQRLTLQDLKMIHKKWFKPEEASALRIKIWNILVDLFRKGNQTD