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ULK3

Gene
ULK3
Protein
Serine/threonine-protein kinase ULK3
Organism
Homo sapiens
Length
472 amino acids
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Mass
53.444 kDa
Sequence
MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTSARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ

Gene
Ulk3
Protein
Serine/threonine-protein kinase ULK3
Organism
Mus musculus
Length
472 amino acids
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity).
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Mass
53.572 kDa
Sequence
MAGPSWGLPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPARRISFKDFFAHPWVDLEHMPSGESLAQARALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTTVQELLREMARDKPRLLAALEVASAALAKEEEAGKEQDALDLYQHSLGELLVLLAAEAPGRRRELLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSSCTLQ

Gene
Ulk3
Protein
Serine/threonine-protein kinase ULK3
Organism
Rattus norvegicus
Length
472 amino acids
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity).
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Mass
53.419 kDa
Sequence
MAGSGWGLPRLDGFILTERLGSGTYATVYKAYAKKATREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPSHRISFQDFFAHPWVDLEHMPSGESLAQATALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTTGQELLREMARDKPRLLAALEVASAAMAKEEEAGKEQDALDLYQHSLGELLLLLAAEAPGRRRELLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSSCTLQ

Gene
ULK3
Protein
Serine/threonine-protein kinase ULK3
Organism
Gallus gallus
Length
468 amino acids
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Mass
53.065 kDa
Sequence
MAGGGCAPPRLDGFVLTERLGTGTYATVYKAYGKRDTREVVAVKCVSKRSLNRASVENLLTEIEILKTIRHPHIVELKDFQWDSDHIYLIMEFCAGGDLSRFIRMRRILPEKVARIFLQQLACALKFLHDHNISHLDLKPQNILLSTPENPQLKLADFGFAQYMSPWDEKHVLRGSPLYMAPEMVCRQQYDARVDLWSVGVILYEALFGRPPFASRSFAELEEKIRSDRAIELPSRPPLSPDCRDLLQRLLERDPLKRISFEEFFAHPFVDMEHMPGPESFCKATNLVVEAVKKDQEGDASAALSLYCKALEYFVPALHYESDARRKEAIRTKVGQYISRAEELKALVASKSKNLLQQGNPAREILKEMAKDKPRLCAALEMASVAVAREEEGKDDGDTLELYQQSLGELLLLLAAEPAGRRRELLHAEIQTLMARAEYLKDQIKMREAQSMGKEALADSVRSSCTLQ

Gene
ulk3
Protein
Serine/threonine-protein kinase ULK3
Organism
Xenopus laevis
Length
468 amino acids
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Mass
53.127 kDa
Sequence
MAAGWAPPRLEDFILTEKLGSGSYATVYKAYRKRNAREVVAIKCVSKKSLNKAAVENLLTEIEILKTVHHPHILELKDFQWDQDYIFLITEYCAGGDLSRFIRTRRILPERIVQVFLQQLASALKFLHEKNISHLDLKPQNILLSRLDRPHLKLADFGFAQHMSSEDAPQALRGSPLYMAPEMVCSKHYDARVDLWSVGVILYEALFGKAPFASKSFSELEEKILSHKTIELPTRPRLSPECRDLLQQLLQRDPDKRISFIEFFAHLFVDLEHMPSAETLEKATRLVVEAVEKDSAGEHSAALTLYCKALEYFIPALHYESDAKRKEAMRSKVCQYISRAEELKVLVSSSNKTLLMQGISGRELLKEMAQDKPRLFSALEVASAAVAKDEEGCACDALDLYQQSLGELLLMLSAESPGRRRELLHAEIQTLMGRAEFLKEQMKTSQWKSESLGQEVLSESVRNSCSLQ