UL52

DNA primase

1293 amino acids

Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.

Belongs to the herpesviridae DNA primase family.

139.922 kDa

MFGFLIGVFFDRREESKCEPLVKHAPAIEPEASEAENYPLSSSADDKILAEALDAVETTILGSGSCLHVTDTAAMPPAGDSAAAAVMMGSHSPGDRLMIEALESVEASRGLTHSADTCSQRCSIALSAPQSPQSRVPEGPIMDSGQIFAVSGAGEEENWIDDEDMALCAADLQIDPIGDAQSVGGSTAACLPPSQKEEIRILYATDGYPVVCSLHLLLGQALLQELYVIAYSHVTEPSAHGGGLLRATFYLLAATGCERQRQRVRPVFVCSFTGEAADKTREALREGKPLMVQDVIASLDEAQSLALHEDLIIALGTICSAGKTAAAPGGDERNLSYNYVASTLPGLRRTLASLMLQYETRVVAAFRRKYNASFSCPFWFVSKFGPSETSLVAVLRYYLLGATQDDGIAGSFDLQGVKDLAVTFPKPGANASGLTAARLNTFAEFSRFWCCSELAGPKAEKLFREYLKTRVSSDTLYVQSLDSLIEKYRHALRLPAKDFVRFVYLAYHEGYNRAAVEAHMEEALRNGGRAETAATRAQSEFFKGLREMCSMPEYFARNVDVAVKRLPVRVAEEHARLRSYGEIPRSGFWGFCWPSYDVSLRINKICAGPLCCLGTQLADAMVRAPPDDGDKGTCAETAATIIHHDSDASGEEEATVKVCGAHMPRANKRAGDGTRISPACNEADTRAPLARLTALAYSDQRPRGIMPVTLLLYSLDDTSSGADTAVKSEAKAQDRPVPVYRVAMPGGGQAFAVVARDQWDKTVTVDVFSGFMAPKSPPESNGPLGSDKDAAAVDDAWTRALLARAWGTSYARRCAANVGASQLYLNRNEVLSDSLAVCNLPLDLDITLKPSSVGRPSMLTLHMAMRSVREAIVLLWSLLFADAEIDPDTYPVYFYKTQCDAAAGDEEASPQRRGVGGGDDDVAWGEEDVEIEEMWGGYYSQTAMNDDMIWDDAPDPQMDIDSDHPAHEPMDDGAGAAIEEMKTAAAARFCRCERKIGFRICVPIPKPYALAGLSVAKATSALVQQAIVLQEKFVEALDQFIADYEFVDSGVYSAGRSLRLPFFAKVNARGVMVGRLLPFLVFPPKCRDRSEFVAQHADPNNFHVGAARRDNPAPTLIITSVTVRRDVLAQDNRAHGKPRAGTARLADALAAVGIVPGNQQGTPGDACAVDASWLLDSVAMPALREYIDEHFPRHAAEYRDARTDCIRVYEGRICAALRRGGAGYMSGRRSNFTCLKYQHRGASMQTVIASVVVAVNSQGLPYAALQTRCFATKCGSNELQTQFTVTLSATKDV

UL52

DNA primase

1066 amino acids

Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.

Belongs to the herpesviridae DNA primase family.

114.654 kDa

MGTEDCDHEGRSVAAPVEVTALYATDGCVITSSLALLTNCLLGAEPLYIFSYDAYRSDAPNGPTGAPTEQERFEGSRALYRDAGGLNGDSFRVTFCLLGTEVGVTHHPKGRTRPMFVCRFERADDVAVLQDALGRGTPLLPAHVTATLDLEATFALHANIIMALTVAIVHNAPARIGSGSTAPLYEPGESMRSVVGRMSLGQRGLTTLFVHHEARVLGAYRRAYYGSAQSPFWFLSKFGPDEKSLVLAARYYLLQAPRLGGAGATYDLQAVKDICATYAIPHDPRPDTLSAASLTSFAAITRFCCTSQYSRGAAAAGFPLYVERRIAADVRETGALEKFIAHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPSPAASTEQPSPLGREAVEQFFRHVRAQLNIREYVKQNVTPRETALAGDAAAAYLRARTYAPAALTPAPAYCGVADSSTKMMGRLAEAERLLVPHGWPAFAPTTPGDDAGGGTAAPQTCGIVKRLLKLAATEQQGTTPPAIAALMQDASVQTPLPVYRITMSPTGQAFAAAARDDWARVTRDARPPEATVVADAAAAPEPGALGRRLTRRICARGPALPPGGLAVGGQMYVNRNEIFNAALAVTNIILDLDIALKEPVPFPRLHEALGHFRRGALAAVQLLFPAARVDPDAYPCYFFKSACRPRAPPVCAGDGPSAGGDDGDGDWFPDAGGPGDEEWEEDTDPMDTTHGPLPDDEAAYLDLLHEQIPAATPSEPDSVVCSCADKIGLRVCLPVPAPYVVHGSLTMRGVARVIQQAVLLDRDFVEAVGSHVKNFLLIDTGVYAHGHSLRLPYFAKIGPDGSACGRLLPVFVIPPACEDVPAFVAAHADPRRFHFHAPPMFSAAPREIRVLHSLGGDYVSFFEKKASRNALEHFGRRETLTEVLGRYDVRPDAGETVEGFASELLGRIVACIEAHFPEHAREYQAVSVRRAVIKDDWVLLQLIPGRGALNQSLSCLRFKHGRASRATARTFLALSVGTNNRLCASLCQQCFATKCDNNRLHTLFTVDAGTPCSRSAPSSTSRPSSS

UL52

DNA primase

1058 amino acids

Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.

Belongs to the herpesviridae DNA primase family.

114.424 kDa

MGQEDGNRGERRAAGTPVEVTALYATDGCVITSSIALLTNSLLGAEPVYIFSYDAYTHDGRADGPTEQDRFEESRALYQASGGLNGDSFRVTFCLLGTEVGGTHQARGRTRPMFVCRFERADDVAALQDALAHGTPLQPDHIAATLDAEATFALHANMILALTVAINNASPRTGRDAAAAQYDQGASLRSLVGRTSLGQRGLTTLYVHHEVRVLAAYRRAYYGSAQSPFWFLSKFGPDEKSLVLTTRYYLLQAQRLGGAGATYDLQAIKDICATYAIPHAPRPDTVSAASLTSFAAITRFCCTSQYARGAAAAGFPLYVERRIAADVRETSALEKFITHDRSCLRVSDREFITYIYLAHFECFSPPRLATHLRAVTTHDPNPAASTEQPSPLGREAVEQFFCHVRAQLNIGEYVKHNVTPRETVLDGDTAKAYLRARTYAPGALTPAPAYCGAVDSATKMMGRLADAEKLLVPRGWPAFAPASPGEDTAGGTPPPQTCGIVKRLLRLAATEQQGPTPPAIAALIRNAAVQTPLPVYRISMVPTGQAFAALAWDDWARITRDARLAEAVVSAEAAAHPDHGALGRRLTDRIRAQGPVMPPGGLDAGGQMYVNRNEIFNGALAITNIILDLDIALKEPVPFRRLHEALGHFRRGALAAVQLLFPAARVDPDAYPCYFFKSACRPGPASVGSGSGLGNDDDGDWFPCYDDAGDEEWAEDPGAMDTSHDPPDDEVAYFDLCHEVGPTAEPRETDSPVCSCTDKIGLRVCMPVPAPYVVHGSLTMRGVARVIQQAVLLDRDFVEAIGSYVKNFLLIDTGVYAHGHSLRLPYFAKIAPDGPACGRLLPVFVIPPACKDVPAFVAAHADPRRFHFHAPPTYLASPREIRVLHSLGGDYVSFFERKASRNALEHFGRRETLTEVLGRYNVQPDAGGTVEGFASELLGRIVACIETHFPEHAGEYQAVSVRRAVSKDDWVLLQLVPVRGTLQQSLSCLRFKHGRASRATARTFVALSVGANNRLCVSLCQQCFAAKCDSNRLHTLFTIDAGTPCSPSVPCSTSQPSS

UL52

DNA primase

962 amino acids

Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.

Belongs to the herpesviridae DNA primase family.

103.329 kDa

MPPSMIRVLYATDGCAITYSLMLLTGQEPSGAVYVVSYAWDGAGLDEAFSLPGERAEAELLARRPGVTFCLTGHVASVRVRPVFVAAATPAVVRALCRGEPLAARDVLEAMDEAATFALHDGLIAALTMVLEQVRPRTGNAEYAPERPLRSIAVGRRGLTSLFVHHETQTLAAFRRLYGNHNTPFWYVARFGPEEKTLVLATRLHLFHPRPAYDLRALKDLLLTYNPRVDPNPSGLDPAGLLSFAALSRFCCLSGYARGPAAAHAARYVDERVRADRAEMGVLRDYISHDRGSLKLPDREFVTYVYLAHFESFNRARLREHLDAVNVTDPAAPVGRSPLGERAAAAFFRHVRAQLNIRDYVAQNVTPSVARLAPAMGAGYVEDRTYAALAADAPRGLCDAAAGLARRVTAVEERLAPHGWVRAPDEEQQQPGADGAVLRRLLELAAAPGGGRARTALGALLGLPDACPPAPVYRVELAHRRQAFAVLAGDAWGRATARRDAAPEMAAHEPAAQMYVSRHEVFNARLAVTNIVLDVDFRLARPVPAGTLEAAMRGFRRAVLDALALLFPEADGDWAAHPCYVYKSACPPGGALAAAAGSASAASSDDGLEEAPWDDDAALADFGAAPGDEDWADWDAGVPAEVYTCDDDEVGVGIGGAGGDPGASALVRAPVPADERPPCGCRAKMGFRVCTPVPSPYAVAGADTVRGLARVLQQAVLLERDFIEPMGPYLQDFTFVDTGVYAHGRSLRLPFFAKVDGGGCHGRLLPFGDAPPGFDDPRNFHFHARPAHAVTRVLHSLGGEYESFFERKAARNREAFFARRTPLADMLRGLAVDAEDRRALEAFVADVAMAPVLRHLDAHFNGRAHEYAGATAQRVVAKPDWVLFQLCGSARFSCLRARHARSPPARTFVALSVDAHDRLCISLSQQCFATKCGSNATRTIFTAEVGQSCSSAGARCTSSSSG

UL52

Packaging protein UL32 homolog

668 amino acids

Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.

Belongs to the herpesviridae UL32 protein family.

74.121 kDa

MNPSTHVSSNGPTTPPHGPHTTFLPPTSPAPSTSSVAAATLCSPQRQAVSRYSGWSTEYTQWHSDLTTELLWHAHPRQVPMDEALAAAAAASYQVNPQHPANRYRHYEFQTLSLGTSEVDELLNCCAEETTCGGTQSTVLTNATNTTSCGGAVAGSSNVGPAGASAACDLDAELAGLETSAADFEQLRRLCAPLAIDTRCNLCAIISICLKQDCDQSWLLEYSLLCFKCSYAPRAALSTLIIMSEFTHLLQQHFSDLRIDDLFRHHVLTVFDFHLHFFINRCFEKQVGDAVDNENVTLNHLAVVRAMVMGEDTVPYNKPRRHPQQKQKNNPYHVEVPQELIDNFLEHSSPSRDRFVQLLFYMWAGTGVMSTTPLTELTHTKFARLDALSTASEREDARMMIEEEEDEEGGEKGGDDPGRHNGGGTSGGFSESTLKKNVGPIYLCPVPAFFTKNQTSTVCLLCELMACSYYDNVVLRELYRRVVSYCQNNVKMVDRIQLVLADLLRECTSPLGAAHEDVARCGLEAPTSPGGDSDYHGLSGVDGALARPDPVFCHVLRQAGVTGIYKHFFCDPQCAGNIRVTNEAVLFGRLHPHHVQEVKLAICHDNYYISRLPRRVWLCITLFKAFQITKRTYKGKVHLADFMRDFTQLLESCDIKLVDPTYVIDKYV

UL52

Packaging protein UL32 homolog

668 amino acids

Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.

Belongs to the herpesviridae UL32 protein family.

74.119 kDa

MNPSTHVSSNGPTTPPHGPHTTFLPPTSPAPSTSSVAAATLCSPQRQAVSRYSGWSTEYTQWHSDLTTELLWHAHPRQVPMDEALAAAAAASYQVNPQHPANRYRHYEFQTLSLGTSEVDELLNCCAEETTCGGTQSTVLTNATNTTSCGGAVAGSSNAGPAGASAACDLDAELAGLETSAADFEQLRRLCAPLAIDTRCNLCAIISICLKQDCDQSWLLEYSLLCFKCSYAPRAALSTLIIMSEFTHLLQQHFSDLRIDDLFRHHVLTVFDFHLHFFINRCFEKQVGDAVDNENVTLNHLAVVRAMVMGEDTVPYNKPRRHPQQKQKNNPYHVEVPQELIDNFLEHSSPSRDRFVQLLFYMWAGTGVMSTTPLTELTHTKFARLDALSTASEREDARMMMEEEEDEEGGEKGGDDPGRHNGGGTSGGFSESTLKKNVGPIYLCPVPAFFTKNQTSTVCLLCELMACSYYDNVVLRELYRRVVSYCQNNVKMVDRIQLVLADLLRECTSPLGAAHEDVARCGLEAPTSPGGDSDYHGLSGVDGALARPDPVFCHVLRQAGVTGIYKHFFCDPQCAGNIRVTNEAVLFGHLHPHHVQEVKLAICHDNYYISRLPRRVWLCITLFKAFQITKRTYKGKVHLADFMRDFTQLLENCDIKLVDPTYVIDKYV